Comparative Evaluation of the Apical Sealability of AH Plus and RealSeal SE Using 5.25% Sodium Hypochlorite with 17% EDTA and 10% Citric Acid as Irrigants—An In Vitro Study -н Mohan Naveen, Arumugam Selvabalaji, Alaguselvaraj Joseph, Chonat Anagha, Kumar K. Krishna

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PB2059: SENSITIVITY AND SUBGROUP ANALYSES FURTHER SUPPORT CLINICAL SIMILARITY IN EFFICACY BETWEEN ABP 959 AND ECULIZUMAB REFERENCE PRODUCT IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEM... -н Austin Kulasekararaj, Francesco Lanza, Alexandros Arvanitakis, Saskia Langemeijer, Satheesh Chonat, Jia Cao, Vincent Chow, Haby Henary

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Voxelotor improves red blood cell functionality in children with sickle cell anaemia: An ancillary study of the HOPE‐KIDS 1 trial -н Satheesh Chonat, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, Sandy Dixon, Margaret Tonda, Clark Brown, David Archer

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Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease -н Satheesh Chonat, Maa-Ohui Quarmyne, Caroline M. Bennett, Christina L. Dean, Clinton H. Joiner, Ross M. Fasano, Sean R. Stowell

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Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal -н Swee Lay Thein, France Pirenne, Ross M. Fasano, Anoosha Habibi, Pablo Bartolucci, Satheesh Chonat, Jeanne E. Hendrickson, Sean R. Stowell

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Recipient priming to one RBC alloantigen directly enhances subsequent alloimmunization in mice -н Seema R. Patel, Ashley Bennett, Kathryn Girard-Pierce, Cheryl L. Maier, Satheesh Chonat, Connie M. Arthur, Patricia E. Zerra, Amanda Mener, Sean R. Stowell

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ESTUDOS EM ANDAMENTO FASE IB E IIA: CROSSWALK-A E CROSSWALK-C, RANDOMIZADOS E CONTROLADOS POR PLACEBO - CROVALIMABE NO TRATAMENTO E PREVENÇÃO DE EPISÓDIOS VASO-OCLUSIVOS NA DOENÇA... -н MA Salvino, B Antmen, FC Asirwa, S Chonat, L Franceschi, P Eleftheriou, A Inati, J Mahlangu, E Nur, S Payá-Pernía, A Charania, D Gradinaru, A Hsia, T Perretti, S Sreckovic, P Bartolucci

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Eculizumab for complement mediated thrombotic microangiopathy in sickle cell disease -н Satheesh Chonat, Sara Graciaa, H. Stella Shin, Joanna G. Newton, Maa-Ohui Quarmyne, Jeanne Boudreaux, Amy Tang, Patricia E. Zerra, Margo R. Rollins, Cassandra D. Josephson, Clark Brown, Clinton H. Joiner, Ross M. Fasano, Sean R. Stowell

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P1473: CLINICALLY RELEVANT HEMOGLOBIN RESPONSE IN ADULTS WITH PYRUVATE KINASE DEFICIENCY TREATED WITH MITAPIVAT – A SUB-ANALYSIS OF THE ACTIVATE TRIAL -н Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthøj, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, Mark Layton, Oliver Andres, Frédéric Galactéros, Koichi Onodera, Satheesh Chonat, Rengyi Xu, Bryan Mcgee, Melissa Dibacco, Jaime Morales, Eduard van Beers

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P1545: DURABILITY OF HEMOGLOBIN RESPONSE AND REDUCTION IN TRANSFUSION BURDEN IS MAINTAINED OVER TIME IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY TREATED WITH MITAPIVAT IN A LONG-TE... -н R. F. Grace, A. Glenthøj, W. Barcellini, M. Verhovsek, J. A. Rothman, M. Morado Arias, D. M. Layton, O. Andres, F. Galactéros, E. J. van Beers, K. Onodera, V. Viprakasit, S. Chonat, J. B. Porter, M. P. Judge, P. A. Kosinski, P. Hawkins, S. Gheuens, R. Xu, B. McGee, V. Beynon, H. Al-Samkari

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Molecular and phenotypic diversity of <I>CBL</I>-mutated juvenile myelomonocytic leukemia -н Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

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Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study -н Eduard J. van Beers, Stephanie van Straaten, D. Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Satheesh Chonat, Janet L. Kwiatkowski, Jennifer A. Rothman, Mukta Sharma, Ellis J. Neufeld, Sujit Sheth, Jenny M. Despotovic, Nina Kollmar, Dagmar Pospíšilová, Christine M. Knoll, Kevin Kuo, Yves D. Pastore, Alexis A. Thompson, Peter E. Newburger, Yaddanapudi Ravindranath, Winfred C. Wang, Marcin W. Wlodarski, Heng Wang, Susanne Holzhauer, Vicky R. Breakey, Madeleine Verhovsek, Joachim Kunz, Melissa A. McNaull, Melissa J. Rose, Heather A. Bradeen, Kathryn Addonizio, Anran Li, Hasan Al-Sayegh, Wendy B. London, Rachael F. Grace

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