An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn's disease with defective antimicrobial activity by Aschenbrenner, D, Nassiri, I, Venkateswaran, S, Pandey, S, Page, M, Drowley, L, Armstrong, M, Kugathasan, S, Fairfax, B, Uhlig, HH

Toward Interpretable Sleep Stage Classification Using Cross-Modal Transformers by Jathurshan Pradeepkumar, Mithunjha Anandakumar, Vinith Kugathasan, Dhinesh Suntharalingham, Simon L. Kappel, Anjula C. De Silva, Chamira U. S. Edussooriya

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An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions by Clark, A, Kugathasan, U, Baskozos, G, Priestman, D, Fugger, N, Che, K, Blesneac, I, Platt, F, Bennett, D

Research Ready: a student-initiated workshop model for developing foundational research skills by Nivetha Sivarajah, Jenevan A. Irranious, Sivagini Krishnamoorthy, Thayaparan Kalaineethan, Deluxeani Kugathasan, Uventhikka Sivanantham, Mary E. McMillan, Natkunam Ketheesan

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An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn’s disease with defective antimicrobial activity by Dominik Aschenbrenner, Isar Nassiri, Suresh Venkateswaran, Sumeet Pandey, Matthew Page, Lauren Drowley, Martin Armstrong, Subra Kugathasan, Benjamin Fairfax, Holm H. Uhlig

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Single-cell transcriptomics of rectal organoids from individuals with perianal fistulizing Crohn’s disease reveals patient-specific signatures by Shanta Murthy, Murugadas Anbazhagan, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Ranjit Pelia, David J. Cutler, Jason D. Matthews, Subra Kugathasan

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Persistent Inflammation of the Rectum in Perianal Fistulizing Crohn's Disease Is Associated With Goblet Cell Function by Savannah Washburn, Sushma C. Maddipatla, Shanta Murthy, Anne Dodd, Ranjit S. Pelia, Vasantha L. Kolachala, Duke Geem, Jason D. Matthews, Greg Gibson, Subra Kugathasan

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PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells by Murugadas Anbazhagan, Garima Sharma, Shanta Murthy, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Amanda Randunne, David J. Cutler, Subra Kugathasan, Jason D. Matthews

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Adults born preterm have lower peripheral skeletal muscle area and strength by Alyson Deprez, Ramy El-Jalbout, Anik Cloutier, Dany H. Gagnon, Andréa Gagnon Hamelin, Marie-Eve Mathieu, Thiffya Arabi Kugathasan, Nicolas A. Dumont, Anne Monique Nuyt, Thuy Mai Luu

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Prevalence of tissue transglutaminase antibodies and IgA deficiency are not increased in juvenile idiopathic arthritis: a case-control study by Angela Taneja Kohli, Aimee O. Hersh, Lori Ponder, Lai Hin Kimi Chan, Kelly A. Rouster-Stevens, Anne E. Tebo, Subra Kugathasan, Stephen L. Guthery, John F. Bohnsack, Sampath Prahalad

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Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23 by Aschenbrenner, D, Quaranta, M, Banerjee, S, Ilott, N, Jansen, J, Steere, B, Chen, Y, Ho, S, Cox, K, Arancibia, C, Coles, M, Gaffney, E, Travis, S, Denson, L, Kugathasan, S, Schmitz, J, Powrie, F, Sansom, S, Uhlig, H

Genome-wide association identifies diverse causes of common variable immunodeficiency by Orange, J, Glessner, J, Resnick, E, Sullivan, K, Lucas, M, Ferry, B, Kim, C, Hou, C, Wang, F, Chiavacci, R, Kugathasan, S, Sleasman, J, Baldassano, R, Perez, E, Chapel, H, Cunningham-Rundles, C, Hakonarson, H

Genome-wide association identifies diverse causes of common variable immunodeficiency. by Orange, J, Glessner, J, Resnick, E, Sullivan, K, Lucas, M, Ferry, B, Kim, C, Hou, C, Wang, F, Chiavacci, R, Kugathasan, S, Sleasman, J, Baldassano, R, Perez, E, Chapel, H, Cunningham-Rundles, C, Hakonarson, H

Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance by Aschenbrenner, D, Quaranta, M, Banerjee, S, Ilott, N, Jansen, J, Steere, B, Chen, Y-H, Ho, S, Cox, K, Arancibia-Cárcamo, CV, Coles, M, Gaffney, E, Travis, SP, Denson, L, Kugathasan, S, Schmitz, J, Powrie, F, Sansom, SN, Uhlig, HH

Common variants at five new loci associated with early-onset inflammatory bowel disease. by Imielinski, M, Baldassano, R, Griffiths, A, Russell, R, Annese, V, Dubinsky, M, Kugathasan, S, Bradfield, J, Walters, T, Sleiman, P, Kim, C, Muise, A, Wang, K, Glessner, J, Saeed, S, Zhang, H, Frackelton, E, Hou, C, Flory, J, Otieno, G, Chiavacci, R, Grundmeier, R, Castro, M, Latiano, A, Dallapiccola, B

In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control by Ansari, A, Marchi, E, Ramamurthy, N, Aschenbrenner, D, Morgan, S, Hackstein, C-P, Lin, S-K, Bowden, R, Sharma, E, Pedergnana, V, Venkateswaran, S, Kugathasan, S, Mo, A, Gibson, G, Cooke, G, McLauchlan, J, Baillie, JK, Teichmann, S, Mentzer, A, Knight, J, Todd, J, Hinks, T, Barnes, E, Klenerman, P, Uhlig, H

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients by Hall, Andrew Brantley, Yassour, Moran, Sauk, Jenny, Garner, Ashley, Jiang, Xiaofang, Arthur, Timothy, Vatanen, Tommi, Fornelos, Nadine, Wilson, Robin, Bertha, Madeline, Cohen, Melissa, Garber, John, Khalili, Hamed, Gevers, Dirk, Ananthakrishnan, Ashwin N., Kugathasan, Subra, Lander, Eric S., Vlamakis, Hera, Xavier, Ramnik J., Huttenhower, Curtis, Lagoudas, Georgia K, Blainey, Paul C

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Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease. by Schwerd, T, Pandey, S, Yang, H, Bagola, K, Jameson, E, Jung, J, Lachmann, R, Shah, N, Patel, S, Booth, C, Runz, H, Düker, G, Bettels, R, Rohrbach, M, Kugathasan, S, Chapel, H, Keshav, S, Elkadri, A, Platt, N, Muise, A, Koletzko, S, Xavier, R, Marquardt, T, Powrie, F, Wraith, J, Gyrd-Hansen, M, Platt, F, Uhlig, H

HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression ana... by Gupta, RK, Gregson, J, Parkin, N, Haile-Selassie, H, Tanuri, A, Forero, L, Kaleebu, P, Watera, C, Aghokeng, A, Mutenda, N, Dzangare, J, Hone, S, Hang, ZZ, Garcia, J, Garcia, Z, Marchorro, P, Beteta, E, Giron, A, Hamers, R, Inzaule, S, Frenkel, LM, Chung, MH, de Oliveira, T, Pillay, D, Naidoo, K, Kharsany, A, Kugathasan, R, Cutino, T, Hunt, G, Rios, S, Doherty, M, Jordan, MR, Bertagnolio, S

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease by Schwerd, T, Bryant, RV, Pandey, S, Capitani, M, Meran, L, Cazier, JB, Jung, J, Mondal, K, Parkes, M, Mathew, CG, Fiedler, K, McCarthy, DJ, Sullivan, PB, Rodrigues, A, Travis, SPL, Moore, C, Sambrook, J, Ouwehand, WH, Roberts, DJ, Danesh, J, Russell, RK, Wilson, DC, Kelsen, JR, Cornall, R, Denson, LA, Kugathasan, S, Knaus, UG, Serra, EG, Anderson, CA, Duerr, RH, McGovern, DP, Cho, J, Powrie, F, Li, VS, Muise, AM, Uhlig, HH