Subcutaneous bortezomib incorporated into the bortezomib-thalidomide-dexamethasone regimen as part of front-line therapy in the context of autologous stem cell transplantation for... 由 Anne Lok, Julie Mocquard, Jessie Bourcier, Laurence Redelsperger, Antoine Bonnet, Cecile Chauvin, Patrick Thomaré, Beatrice Mahé, Cyrille Touzeau, Philippe Moreau

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Deep and sustained response after venetoclax therapy in a patient with very advanced refractory myeloma with translocation t(11;14) 由 Cyrille Touzeau, Steven Le Gouill, Béatrice Mahé, Jean Samuel Boudreault, Thomas Gastinne, Nicolas Blin, Hélène Caillon, Christelle Dousset, Martine Amiot, Philippe Moreau

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P907: EFFICACY AND SAFETY OF ELRANATAMAB IN HIGH-RISK PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA: A SUBGROUP ANALYSIS FROM MAGNETISMM-3 由 Cyrille Touzeau, Nizar J Bahlis, Christopher Maisel, Lionel Karlin, Asya Nina Varshavsky-Yanovsky, Eric Leip, Umberto Conte, Andrea Viqueira, Sarah M. Larson

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DCE-MRI to distinguish all monoclonal plasma cell disease stages and correlation with diffusion-weighted MRI/PET-based biomarkers in a hybrid simultaneous whole body-2-[18F]FDG-PET... 由 Bastien Jamet, Hatem Necib, Thomas Carlier, Eric Frampas, Juliette Bazin, Paul-Henri Desfontis, Aurélien Monnet, Caroline Bodet-Milin, Philippe Moreau, Cyrille Touzeau, Francoise Kraeber-Bodere

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Immune-related adverse events with bispecific T-cell engager therapy targeting B-cell maturation antigen 由 Bénédicte Piron, Mathilde Bastien, Chloé Antier, Romain Dalla-Torre, Bastien Jamet, Thomas Gastinne, Viviane Dubruille, Philippe Moreau, Jérôme Martin, Antoine Bénichou, Cyrille Touzeau, Benoît Tessoulin

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S186: ACQUIRED RESISTANCE TO BISPECIFIC ANTIBODIES BY GENETIC OR EPIGENETIC INACTIVATION OF THE TARGET IN MULTIPLE MYELOMA 由 Jennifer Derrien, Sarah Gastineau, Antoine Frigout, Nils Giordano, Mia Cherkaoui, Victor Gaborit, Elise Douillard, Magali Devic, Florence Magrangeas, Philippe Moreau, Stéphane Minvielle, Cyrille Touzeau, Eric Letouzé

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The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement 由 Steven Le Gouill, Pascaline Talmant, Cyrille Touzeau, Anne Moreau, Richard Garand, Nadine Juge-Morineau, Fanny Gaillard, Thomas Gastinne, Noël Milpied, Philippe Moreau, Jean Luc Harousseau, Hervé Avet-Loiseau

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S176: DARATUMUMAB CARFILZOMIB LENALIDOMIDE AND DEXAMETHASONE AS INDUCTION THERAPY IN HIGH-RISK TRANSPLANT ELIGIBLE NEWLY DIAGNOSED MYELOMA PATIENTS: RESULTS OF THE PHASE 2 STUDY IF... 由 C. Touzeau, A. Perrrot, C. Hulin, S. Manier, M. Macro, M.-L. Chretien, L. Karlin, O. Decaux, C. Jacquet, M. Tiab, X. Leleu, L. Planchce, H. Avet-Loiseau, P. Moreau

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P10 AN ULTRA-SENSITIVE METHOD FOR SEQUENCING AND MONITORING OF M-PROTEIN IN PERIPHERAL BLOOD (M-INSIGHT) 由 V. Bonifay, V. Vimard, S. Noori, C. Wijnands, C. Touzeau, J. Corre, A. Perrot, P. Moreau, H. Caillon, T. Dejoie, T. Luider, M. VanDuijn, J. Jacobs, A. Van Gool, P. Sonigo

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B04 IMPLEMENTING M-PROTEIN DIAGNOSTICS IN MULTIPLE MYELOMA PATIENTS USING ULTRA-SENSITIVE TARGETED MASS SPECTROMETRY DATA AND AN OFF-THE-SHELF CALIBRATOR 由 C. Wijnands, P. Langerhorst, S. Noori, J. Gloerich, V. Bonifay, C. Touzeau, J. Corre, A. Perrot, P. Moreau, H. Caillon, T. Luider, A. van Gool, T. Dejoie, M. VanDuijn, J. Jacobs

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P929: IXAZOMIB AND DARATUMUMAB WITHOUT DEXAMETHASONE (I-DARA) IN ELDERLY FRAIL RELAPSING MYELOMA (RRMM) PATIENTS: RESULTS OF THE PHASE 2 STUDY IFM 2018-02 OF THE INTERGROUPE FRANCO... 由 M. Macro, C. Touzeau, C. Mariette, S. Manier, S. Brechignac, L. Vincent, B. Hebraud, O. Decaux, S. Schulmann, C. Lenoir, P. Godmer, A. Farge, L. Peyro Saint Paul, J.-J. Parienti, X. Leleu

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PB2129: THE MODAKAFUSP ALFA IINNOVATE CLINICAL DEVELOPMENT PROGRAM: RATIONALE AND DESIGN OF 3 PHASE 1/2 TRIALS OF AN INNATE IMMUNITY ENHANCER FOR MULTIPLE MYELOMA (MM) 由 Sarah A. Holstein, Hira Mian, Cyrille Touzeau, Edwin Kingsley, Dan Vogl, Richard Zuniga, Kaveri Suryanarayan, Shining Wang, Laura Thesillat-Versmee, Yuyin Liu, Tian Chen, Yefei Zhang, Xavier Parot, Hans C. Lee

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Non-interventional Study Evaluating the Mobilization of Stem Cells by Plerixafor Before Salvage Autologous Stem Cell Transplant in Relapsed Multiple Myeloma (IFM-2015-03) 由 Zoe van de Wyngaert, Florent Malard, Cyrille Hulin, Denis Caillot, Clara Mariette, Thierry Facon, Cyrille Touzeau, Aurore Perrot, Philippe Moreau, Benjamin Hebraud, Tarik Kanouni, Farhad Heshmati, Delphine Lebon, Mohamad Mohty, Christian Chabannon

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P891: IXAZOMIB AND DARATUMUMAB WITHOUT DEXAMETHASONE (I-DARA) IN ELDERLY FRAIL RRMM PATIENTS: RESULTS OF THE MULTICENTER PHASE 2 STUDY (IFM 2018-02) OF THE INTERGROUPE FRANCOPHONE... 由 Margaret Macro, Cyrille Touzeau, Clara Mariette, Salomon Manier, Sabine Brechignac, Laure Vincent, Benjamin Hebraud, Olivier Decaux, Samantha Schulmann, Caroline Lenoir, Pascal Godmer, Agathe Farge, Laure Peyro Saint Paul, Jean-Jacques Parienti, Xavier Leleu

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S194: TECLISTAMAB (TEC) + NIROGACESTAT (NIRO) IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): THE PHASE 1B MAJESTEC-2 STUDY 由 Fritz Offner, Olivier Decaux, Cyrille Hulin, Sébastien Anguille, Anne Sophie Michallet, Luciano Costa, Cyrille Touzeau, Kevin Boyd, Deeksha Vishwamitra, Yue Guo, Zhuolu Niu, Julie Larsen, Lingling Chen, Arnob Banerjee, Jenna Goldberg, Jeffrey Matous

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Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study 由 Laurent Garderet, Eric Beohou, Denis Caillot, Anne Marie Stoppa, Cyrille Touzeau, Marie Lorraine Chretien, Lionel Karlin, Philippe Moreau, Jean Fontan, Didier Blaise, Emmanuelle Polge, Mor Seny Gueye, Souhila Ikhlef, Zora Marjanovic, Myriam Labopin, Mohamad Mohty

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P30 SINGLE COHORT RESULTS FROM MAJESTEC-2: TECLISTAMAB (TEC) IN COMBINATION WITH SUBCUTANEOUS DARATUMUMAB (DARA) AND LENALIDOMIDE (LEN) IN PATIENTS WITH MULTIPLE MYELOMA (MM) 由 E. Searle, H. Quach, S. Wong, L. Costa, C. Hulin, W. Janowski, J. Berdeja, S. Anguille, J. Matous, C. Touzeau, A. Michallet, M. Husnik, D. Vishwamitra, Z. Niu, J. Larsen, L. Chen, J. Goldberg, R. Popat, A. Spencer

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All-oral triplet combination of ixazomib, lenalidomide, and dexamethasone in newly diagnosed transplant-eligible multiple myeloma patients: final results of the phase II IFM 2013-0... 由 Cyrille Touzeau, Aurore Perrot, Murielle Roussel, Lionel Karlin, Lotfi Benboubker, Caroline Jacquet, Mohamad Mohty, Thierry Facon, Salomon Manier, Marie-Lorraine Chretien, Mourad Tiab, Cyrille Hulin, Xavier Leleu, Hervé Avet Loiseau, Thomas Dejoie, Lucie Planche, Michel Attal, Philippe Moreau

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S184: EVALUATING TECLISTAMAB IN PATIENTS WITH RELAPSED/ REFRACTORY MULTIPLE MYELOMA FOLLOWING EXPOSURE TO OTHER B-CELL MATURATION ANTIGEN (BCMA)-TARGETED AGENTS 由 C. Touzeau, A. Krishnan, P. Moreau, A. Perrot, S. Z. Usmani, S. Manier, M. Cavo, C. Martinez-Chamorro, A. Nooka, T. Martin, L. Karlin, X. Leleu, N. Bahlis, B. Besemer, L. Pei, R. Verona, S. Girgis, C. Uhlar, R. Kobos, A. Garfall

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Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53‐deficient myeloma cells 由 Romane Durand, Céline Bellanger, Géraldine Descamps, Christelle Dousset, Sophie Maïga, Jennifer Derrien, Laura Thirouard, Louise Bouard, Hélène Asnagli, Philip Beer, Andrew Parker, Patricia Gomez‐Bougie, Marie‐Claire Devilder, Philippe Moreau, Cyrille Touzeau, Agnès Moreau‐Aubry, David Chiron, Catherine Pellat‐Deceunynck

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