Tumour necrosis factor signalling in health and disease [version 1; referees: 2 approved] by Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael McDermott

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Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation by Samuel Lara-Reyna, Samuel Lara-Reyna, Samuel Lara-Reyna, Thomas Scambler, Thomas Scambler, Jonathan Holbrook, Jonathan Holbrook, Jonathan Holbrook, Chi Wong, Chi Wong, Chi Wong, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Fabio Martinon, Fabio Martinon, Sinisa Savic, Sinisa Savic, Sinisa Savic, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott

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Inflammasome activation: from molecular mechanisms to autoinflammation by Samuel Lara‐Reyna, Emily A Caseley, Joanne Topping, François Rodrigues, Jorge Jimenez Macias, Sean E Lawler, Michael F McDermott

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Evidence of B Cell Clonality and Investigation Into Properties of the IgM in Patients With Schnitzler Syndrome by Shelly Pathak, Dorota Rowczenio, Samuel Lara-Reyna, Mark Kacar, Roger Owen, Gina Doody, Karoline Krause, Helen Lachmann, Rainer Doffinger, Darren Newton, Sinisa Savic

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ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis by Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott

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Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen by Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May

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Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β by John D. O’Neil, Oliwia O. Bolimowska, Sally A. Clayton, Tina Tang, Kalbinder K. Daley, Samuel Lara-Reyna, Jordan Warner, Claire S. Martin, Rahul Y. Mahida, Rowan S. Hardy, J. Simon C. Arthur, Andrew R. Clark

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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis by Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency by Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Dewi Astuti, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Samuel Lara-Reyna, Miriam E. Korsgen, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Georgina W. Hughes, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Eva-Maria Frickel, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar

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