Key advances in vaccine development for tuberculosis—success and challenges by Rocky Lai, Abiola F. Ogunsola, Tasfia Rakib, Samuel M. Behar

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Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis by Preeti Thakur, Rujapak Sutiwisesak, Yu-Jung Lu, Samuel M. Behar

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iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. by Alissa C Rothchild, Pushpa Jayaraman, Cláudio Nunes-Alves, Samuel M Behar

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Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells by Rocky Lai, Travis Williams, Tasfia Rakib, Jinhee Lee, Samuel M. Behar

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Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. by Isabel Sada-Ovalle, Asako Chiba, Adaena Gonzales, Michael B Brenner, Samuel M Behar

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CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis. by Jinhee Lee, Shayla Boyce, Jennifer Powers, Christina Baer, Christopher M Sassetti, Samuel M Behar

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Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis. by Stephen M Carpenter, Jason D Yang, Jinhee Lee, Palmira Barreira-Silva, Samuel M Behar

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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection by Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar

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A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis. by Stephen M Carpenter, Cláudio Nunes-Alves, Matthew G Booty, Sing Sing Way, Samuel M Behar

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Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells by Michael C Kiritsy, Katelyn McCann, Daniel Mott, Steven M Holland, Samuel M Behar, Christopher M Sassetti, Andrew J Olive

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TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection. by Pushpa Jayaraman, Miye K Jacques, Chen Zhu, Katherine M Steblenko, Britni L Stowell, Asaf Madi, Ana C Anderson, Vijay K Kuchroo, Samuel M Behar

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Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during <italic toggle="yes">Mycobacterium tuberculosis</italic> Infection by Alissa C. Rothchild, Britni Stowell, Girija Goyal, Cláudio Nunes-Alves, Qianting Yang, Kadamba Papavinasasundaram, Christopher M. Sassetti, Glenn Dranoff, Xinchun Chen, Jinhee Lee, Samuel M. Behar

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Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes by Allison F. Carey, Xin Wang, Nico Cicchetti, Caitlin N. Spaulding, Qingyun Liu, Forrest Hopkins, Jessica Brown, Jaimie Sixsmith, Rujapak Sutiwisesak, Samuel M. Behar, Thomas R. Ioerger, Sarah M. Fortune

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EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. by Alejandra Garces, Krishnamohan Atmakuri, Michael R Chase, Joshua S Woodworth, Bryan Krastins, Alissa C Rothchild, Talia L Ramsdell, Mary F Lopez, Samuel M Behar, David A Sarracino, Sarah M Fortune

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Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages. by Jason D Yang, Daniel Mott, Rujapak Sutiwisesak, Yu-Jung Lu, Fiona Raso, Britni Stowell, Greg Hunter Babunovic, Jinhee Lee, Steve M Carpenter, Sing Sing Way, Sarah M Fortune, Samuel M Behar

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A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. by Rujapak Sutiwisesak, Nathan D Hicks, Shayla Boyce, Kenan C Murphy, Kadamba Papavinasasundaram, Stephen M Carpenter, Julie Boucau, Neelambari Joshi, Sylvie Le Gall, Sarah M Fortune, Christopher M Sassetti, Samuel M Behar

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Host genetic background is a barrier to broadly effective vaccine–mediated protection against tuberculosis by Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar

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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice by Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, Christopher M. Sassetti

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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection. by Cláudio Nunes-Alves, Matthew G Booty, Stephen M Carpenter, Alissa C Rothchild, Constance J Martin, Danielle Desjardins, Katherine Steblenko, Henrik N Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M Behar

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Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) by Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar

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