Structural Insights into Novel 15-Prostaglandin Dehydrogenase Inhibitors by Prema L. Mallipeddi, Yongyou Zhang, Hongyun Li, Sanford D. Markowitz, Bruce Posner

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GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers. by Ryan E Fecteau, James Lutterbaugh, Sanford D Markowitz, Joseph Willis, Kishore Guda

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Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. by Cheryl L Thompson, Stephen P Fink, James D Lutterbaugh, Robert C Elston, Martina L Veigl, Sanford D Markowitz, Li Li

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NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. by Yanxin Luo, Andrew M Kaz, Samornmas Kanngurn, Piri Welsch, Shelli M Morris, Jianping Wang, James D Lutterbaugh, Sanford D Markowitz, William M Grady

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A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support by Amar Desai, Yongyou Zhang, Youngsoo Park, Dawn M. Dawson, Gretchen A. Larusch, Lakshmi Kasturi, David Wald, Joseph M. Ready, Stanton L. Gerson, Sanford D. Markowitz

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Polymer Microparticles Prolong Delivery of the 15-PGDH Inhibitor SW033291 by Alan B. Dogan, Nathan A. Rohner, Julianne N. P. Smith, Jessica A. Kilgore, Noelle S. Williams, Sanford D. Markowitz, Horst A. von Recum, Amar B. Desai

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Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system by Wei Huang, Hongyun Li, Janna Kiselar, Stephen P. Fink, Sagar Regmi, Alexander Day, Yiyuan Yuan, Mark Chance, Joseph M. Ready, Sanford D. Markowitz, Derek J. Taylor

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15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury by Byeong Woo Kim, Hye Jung Kim, Sun-Hee Kim, Hyung Joo Baik, Mi Seon Kang, Dong-Hyun Kim, Sanford D. Markowitz, Sun Woo Kang, Ki Beom Bae

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Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial by Sushma S. Thomas, Karen W. Makar, Lin Li, Yingye Zheng, Peiying Yang, Lisa Levy, Rebecca Y. Rudolph, Paul D. Lampe, Min Yan, Sanford D. Markowitz, Jeannette Bigler, Johanna W. Lampe, John D. Potter

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15-PGDH regulates hematopoietic and gastrointestinal fitness during aging. by Won Jin Ho, Julianne N P Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V Broncano, Lakshmi Kasturi, Dawn M Dawson, Stanton L Gerson, Sanford D Markowitz, Amar B Desai

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A nonrandomized trial of vitamin D supplementation for Barrett's esophagus. by Linda C Cummings, Prashanthi N Thota, Joseph E Willis, Yanwen Chen, Gregory S Cooper, Nancy Furey, Beth Bednarchik, Bronia M Alashkar, John Dumot, Ashley L Faulx, Stephen P Fink, Adam M Kresak, Basel Abusneineh, Jill Barnholtz-Sloan, Patrick Leahy, Martina L Veigl, Amitabh Chak, Sanford D Markowitz

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Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome by Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz, Peter C. Scacheri

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A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis. by Sanford D Markowitz, Nora L Nock, Stephanie L Schmit, Zsofia K Stadler, Vijai Joseph, Lu Zhang, Joseph E Willis, Peter Scacheri, Martina Veigl, Mark D Adams, Leon Raskin, John F Sullivan, Kelly Stratton, Jinru Shia, Nathan Ellis, Hedy S Rennert, Christopher Manschreck, Li Li, Kenneth Offit, Robert C Elston, Gadi Rennert, Stephen B Gruber

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Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study. by Xiangqing Sun, Apoorva K Chandar, Marcia I Canto, Prashanthi N Thota, Malcom Brock, Nicholas J Shaheen, David G Beer, Jean S Wang, Gary W Falk, Prasad G Iyer, Julian A Abrams, Medha Venkat-Ramani, Martina Veigl, Alexander Miron, Joseph Willis, Deepa T Patil, Ilke Nalbantoglu, Kishore Guda, Sanford D Markowitz, Xiaofeng Zhu, Robert Elston, Amitabh Chak

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Two Distinct Categories of Focal Deletions in Cancer Genomes. by Megha Rajaram, Jianping Zhang, Tim Wang, Jinyu Li, Cem Kuscu, Huan Qi, Mamoru Kato, Vladimir Grubor, Robert J Weil, Aslaug Helland, Anne-Lise Borrenson-Dale, Kathleen R Cho, Douglas A Levine, Alan N Houghton, Jedd D Wolchok, Lois Myeroff, Sanford D Markowitz, Scott W Lowe, Michael Zhang, Alex Krasnitz, Robert Lucito, David Mu, R Scott Powers

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Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2) by Jaeil Kim, Eun-ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P. Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanford D. Markowitz, Sang-Yeob Kim, Seung-Jae Myung

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A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 by Minhong Jeun, Hyo Jeong Lee, Sungwook Park, Eun‐ju Do, Jaewon Choi, You‐Na Sung, Seung‐Mo Hong, Sang‐Yeob Kim, Dong‐Hee Kim, Ja Young Kang, Hye‐Nam Son, Jinmyoung Joo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Jaewon Choe, Suk‐Kyun Yang, Helen Moinova, Sanford D. Markowitz, Kwan Hyi Lee, Seung‐Jae Myung

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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis by Nikos Papadimitriou, Niki Dimou, Konstantinos K. Tsilidis, Barbara Banbury, Richard M. Martin, Sarah J. Lewis, Nabila Kazmi, Timothy M. Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I. Berndt, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Bas Bueno-de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Li Hsu, José María Huerta, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford D. Markowitz, Giovanna Masala, Anne M. May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Vittorio Perduca, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L. Schmit, Robert E. Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen N. Thibodeau, Ruth C. Travis, Antonia Trichopoulou, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Marc J. Gunter, Neil Murphy

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