HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models by Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan

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Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells by Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S., Lindquist, Susan

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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis by Dai, Chengkai, Santagata, Sandro, Tang, Zijian, Shi, Jiayuan, Cao, Junxia, Kwon, Hyoungtae, Bronson, Roderick T., Whitesell, Luke, Lindquist, Susan

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Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models by Lindquist, Susan, Caldwell, Guy A., Caldwell, Kim A., Naumann, Todd A., Santagata, Sandro, McCaffery, J. Michael, Hamamichi, Shusei, Kritzer, Joshua A.

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Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers by Tsvetkov, Peter, Brune, Zarina, Thiru, Prathapan, Ghandi, Mahmoud, Santagata, Sandro, Whitesell, Luke, Sokol, Ethan Samuel, Jin, Dexter X., Gupta, Piyush, Lindquist, Susan, Garraway, Levi A.

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HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers by Mendillo, Marc L., Santagata, Sandro, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan, Koeva, Martina I

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High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer by Santagata, Sandro, Mendillo, Marc L., Whitesell, Luke, Lindquist, Susan, Hu, Rong, Lin, Nancy U., Collins, Laura C., Hankinson, Susan E., Schnitt, Stuart J., Tamimi, Rulla M., Ince, Tan A.

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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy by Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L., Sholl, Lynette M., Ben-Aharon, Irit, Beck, Andrew H., Dias-Santagata, Dora, Stemmer, Salomon M., Whitesell, Luke, Koeva, Martina I, Lindquist, Susan

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Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation by Jaeger, Alex M., Stopfer, Lauren Elizabeth, Lee, Sunmin, Gaglia, Giorgio, Sandel, Demi, Santagata, Sandro, Lin, Nancy U., Trepel, Jane B., White, Forest M., Jacks, Tyler E, Lindquist, Susan, Whitesell, Luke

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Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis by Santagata, Sandro, Xu, Ya-ming, Wijeratne, E. M. Kithsiri, Kontnik, Renee, Rooney, Christine, Perley, Casey C., Kwon, Hyoungtae, Clardy, Jon, Kesari, Santosh, Whitesell, Luke, Lindquist, Susan, Gunatilaka, A. A. Leslie

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome by Tsvetkov, Peter, Zhao, Jinghui, Cikes, Domagoj, Varadarajan, Malini, Santagata, Sandro, Lindquist, Susan, Mendillo, Marc L., Carette, Jan E., Merrill, Parker H., van Diemen, Ferdy R., Penninger, Josef M., Goldberg, Alfred L., Brummelkamp, Thijn R.

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Localized metabolomic gradients in patient-derived xenograft models of glioblastoma by Randall, Elizabeth C, Lopez, Begoña GC, Peng, Sen, Regan, Michael S, Abdelmoula, Walid M, Basu, Sankha S, Santagata, Sandro, Yoon, Haejin, Haigis, Marcia C, Agar, Jeffrey N, Tran, Nhan L, Elmquist, William F, White, Forest M, Sarkaria, Jann N, Agar, Nathalie YR

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Localized metabolomic gradients in patient-derived xenograft models of glioblastoma by Randall, Elizabeth C, Lopez, Begoña GC, Peng, Sen, Regan, Michael S, Abdelmoula, Walid M, Basu, Sankha S, Santagata, Sandro, Yoon, Haejin, Haigis, Marcia C, Agar, Jeffrey N, Tran, Nhan L, Elmquist, William F, White, Forest M., Sarkaria, Jann N, Agar, Nathalie YR

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Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations by Lengner, Christopher J., Gimelbrant, Alexander A., Erwin, Jennifer A., Cheng, Albert W., Guenther, Matthew G., Welstead, G. Grant, Alagappan, Raaji, Frampton, Garrett M., Xu, Ping, Muffat, Julien, Santagata, Sandro, Powers, Doug, Barrett, C. Brent, Young, Richard A., Lee, Jeannie T., Jaenisch, Rudolf, Mitalipova, Maisam

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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors by Burger, Megan L, Cruz, Amanda M, Crossland, Grace E, Gaglia, Giorgio, Ritch, Cecily C, Blatt, Sarah E, Bhutkar, Arjun, Canner, David, Kienka, Tamina, Tavana, Sara Z, Barandiaran, Alexia L, Garmilla, Andrea, Schenkel, Jason M, Hillman, Michelle, de los Rios Kobara, Izumi, Li, Amy, Jaeger, Alex M, Hwang, William L, Westcott, Peter MK, Manos, Michael P, Holovatska, Marta M, Hodi, F Stephen, Regev, Aviv, Santagata, Sandro, Jacks, Tyler

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MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging by Schapiro, Denis, Sokolov, Artem, Yapp, Clarence, Chen, Yu-An, Muhlich, Jeremy L, Hess, Joshua, Creason, Allison L, Nirmal, Ajit J, Baker, Gregory J, Nariya, Maulik K, Lin, Jia-Ren, Maliga, Zoltan, Jacobson, Connor A, Hodgman, Matthew W, Ruokonen, Juha, Farhi, Samouil L, Abbondanza, Domenic, McKinley, Eliot T, Persson, Daniel, Betts, Courtney, Sivagnanam, Shamilene, Regev, Aviv, Goecks, Jeremy, Coffey, Robert J, Coussens, Lisa M, Santagata, Sandro, Sorger, Peter K

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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred Chiu-Lai, Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B, Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

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