1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells by Philip D Greenberg, Christopher A Klebanoff, Kim Nguyen, Gary Shapiro, Joshua Francis, Cheryl Black, Anthony Thomas, Meghan D Storlie, Allison P Drain, Nicholas Rouillard, Nathaniel Swanson, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, James Parsons, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Gregory J Cost, Thomas M Schmitt, Smita S Chandran, Ankit Gupta, Damien Hallet, Loic Vincent

355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses by Philip D Greenberg, Christopher A Klebanoff, Kim Nguyen, Gary Shapiro, Joshua Francis, Cheryl Black, Anthony Thomas, Meghan D Storlie, Allison P Drain, Nicholas Rouillard, Nathaniel Swanson, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, James Parsons, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Gregory J Cost, Thomas M Schmitt, Smita S Chandran, Ankit Gupta, Damien Hallet, Loic Vincent