Endocytosis as a critical regulator of hematopoietic stem cell fate —implications for hematopoietic stem cell and gene therapy by Prathibha Babu Chandraprabha, Saravanabhavan Thangavel

Get full text

Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy by Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan, Saravanabhavan Thangavel

Get full text

Current approaches and potential challenges in the delivery of gene editing cargos into hematopoietic stem and progenitor cells by Ramya Murugesan, Ramya Murugesan, Karthik V. Karuppusamy, Karthik V. Karuppusamy, Srujan Marepally, Saravanabhavan Thangavel

Get full text

Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections by Priya Dharmalingam, Hari Krishna R. Rachamalla, Brijesh Lohchania, Bhanuprasad Bandlamudi, Saravanabhavan Thangavel, Mohankumar K. Murugesan, Rajkumar Banerjee, Arabinda Chaudhuri, Chandrashekhar Voshavar, Srujan Marepally

Get full text

Correction to “Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections” by Priya Dharmalingam, Hari Krishna R. Rachamalla, Brijesh Lohchania, Bhanuprasad Bandlamudi, Saravanabhavan Thangavel, Mohankumar K. Murugesan, Rajkumar Banerjee, Arabinda Chaudhuri, Chandrashekhar Voshavar, Srujan Marepally

Get full text

Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System by Gokulnath Mahalingam, Hari Krishnareddy Rachamalla, Porkizhi Arjunan, Yogapriya Periyasami, Salma M, Saravanabhavan Thangavel, Kumarasamypet M. Mohankumar, Mahesh Moorthy, Shaji R. Velayudhan, Alok Srivastava, Srujan Marepally

Get full text

Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

Get full text

Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor by Gokulnath Mahalingam, Porkizhi Arjunan, Yogapriya Periyasami, Ajay Kumar Dhyani, Nivedita Devaraju, Vignesh Rajendiran, Abisha Crystal Christopher, Ramya Devi KT, Immanuel Dhanasingh, Saravanabhavan Thangavel, Mohankumar Murugesan, Mahesh Moorthy, Alok Srivastava, Srujan Marepally

Get full text

Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways by Brijesh Lohchania, Brijesh Lohchania, Abisha Crystal Christopher, Abisha Crystal Christopher, Porkizhi Arjunan, Porkizhi Arjunan, Gokulnath Mahalingam, Durga Kathirvelu, Aishwarya Prasannan, Vigneshwaran Venkatesan, Vigneshwaran Venkatesan, Pankaj Taneja, Mohan Kumar KM, Saravanabhavan Thangavel, Srujan Marepally

Get full text

Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications by Abhirup Bagchi, Nivedhitha Devaraju, Karthik Chambayil, Vignesh Rajendiran, Vigneshwaran Venkatesan, Nilofer Sayed, Aswin Anand Pai, Aneesha Nath, Ernest David, Yukio Nakamura, Poonkuzhali Balasubramanian, Alok Srivastava, Saravanabhavan Thangavel, Kumarasamypet M. Mohankumar, Shaji R. Velayudhan

Get full text

Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells by Abhirup Bagchi, Aneesha Nath, Vasanth Thamodaran, Smitha Ijee, Dhavapriya Palani, Vignesh Rajendiran, Vigneshwaran Venkatesan, Phaneendra Datari, Aswin Anand Pai, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Yukio Nakamura, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, Saravanabhavan Thangavel, Shaji R. Velayudhan

Get full text

Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors by Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Joshua Paul, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Periyasami, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R. Velayudhan, Gregory A. Newby, Srujan Marepally, Alok Srivastava, Kumarasamypet M. Mohankumar

Get full text

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies by Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel

Get full text

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin by Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar

Get full text

Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2 by Anila George, Anila George, Nithin Sam Ravi, Nithin Sam Ravi, Kirti Prasad, Kirti Prasad, Lokesh Panigrahi, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Vignesh Rajendiran, Nivedhitha Devaraju, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Shaji R. Velayudhan, Alok Srivastava, Alok Srivastava, Kumarasamypet M. Mohankumar, Kumarasamypet M. Mohankumar

Get full text