Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial Yazar: Jeffrey A. How, Amir A. Jazaeri, Pamela T. Soliman, Nicole D. Fleming, Jing Gong, Sarina A. Piha-Paul, Filip Janku, Bettzy Stephen, Aung Naing

Tam Metin Erişim

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with... Yazar: Sen Zhang, Jacques Moisan, Aung Naing, Kyriakos P Papadopoulos, Elizabeth Hussey, Joseph P Eder, Sarina A Piha-Paul, Claude Gimmi, Vera Hildebrand, Vinayak Hosagrahara, Christina Habermehl

Tam Metin Erişim

A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors Yazar: Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

Tam Metin Erişim

Phase I study of sapanisertib (CB‐228/TAK‐228/MLN0128) in combination with ziv‐aflibercept in patients with advanced solid tumors Yazar: Niamh Coleman, Bettzy Stephen, Siqing Fu, Daniel Karp, Vivek Subbiah, Jordi Rodon Ahnert, Sarina A. Piha‐Paul, John Wright, Senait N. Fessahaye, Fengying Ouyang, Bulent Yilmaz, Funda Meric‐Bernstam, Aung Naing

Tam Metin Erişim

Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors Yazar: Aung Naing, Xiaoping Zhang, David S Hong, Sarina A Piha-Paul, Ruslan D Novosiadly, Shaun O'Brien, Rasika Suryawanshi, Rahul A Sheth, Blessie E Nelson, Amy Xu, Lora Hamuro, Derrick McKinley

Tam Metin Erişim

Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial Yazar: Vivek Subbiah, Ecaterina Ileana Dumbrava, Yunfang Jiang, Kyaw Z. Thein, Aung Naing, David S. Hong, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Filip Janku, Funda Meric-Bernstam, Razelle Kurzrock, Gerald Falchook

Tam Metin Erişim

764 A phase 1, first-in-human (FIH), open-label, dose-finding and expansion study of XmAb808, a B7H3 x CD28 bispecific antibody, in combination with pembrolizumab in patients with... Yazar: Benjamin Thompson, Li Yao, Yana G Najjar, Siwen Hu-Lieskovan, Raphael Clynes, Bartosz Chmielowski, Mark N Stein, Sarina A Piha-Paul, Patricia McGovern, Judy S Wang, Benjamin Garmezy, Manojkumar Bupathi, Jitendra Kanodia

Multidisciplinary Care of a Large Brain Metastasis in a Patient with Hormone-Receptor-Positive Breast Cancer with Ataxia-Telangiectasia Mutation Yazar: Anca Chelariu-Raicu, Sarina A. Piha-Paul, Mariana Chavez-MacGregor, Jason Johnson, Raymond Sawaya, Mary Frances McAleer, Alissa Nguyen, Audrey Hartnett, Apostolia M. Tsimberidou, Funda Meric-Bernstam, Ecaterina E. Dumbrava

Tam Metin Erişim

744 Assessment of safety and immunologic activity of nemvaleukin alfa in patients with advanced solid tumors treated with less frequent intravenous dosing (ARTISTRY-3) Yazar: Aranzazu Manzano, Emiliano Calvo, Sarina A Piha-Paul, Yangchun Du, Nehal J Lakhani, Rita Dalal, Alexander I Spira, Sonali Panchabhai, Justin A Call, Maria J de Miguel, Shwetha Asha, Clifford DiLea, Bhaskar Rege

FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. Yazar: Denis L Jardim, Jennifer J Wheler, Kenneth Hess, Apostolia M Tsimberidou, Ralph Zinner, Filip Janku, Vivek Subbiah, Aung Naing, Sarina A Piha-Paul, Shannon N Westin, Sinchita Roy-Chowdhuri, Funda Meric-Bernstam, David S Hong

Tam Metin Erişim

Associations between the gut microbiome and fatigue in cancer patients Yazar: Joud Hajjar, Tito Mendoza, Liangliang Zhang, Siqing Fu, Sarina A. Piha-Paul, David S. Hong, Filip Janku, Daniel D. Karp, Alexej Ballhausen, Jing Gong, Abdulrazzak Zarifa, Christine B. Peterson, Funda Meric-Bernstam, Robert Jenq, Aung Naing

Tam Metin Erişim

Manufacturing‐dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development Yazar: Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul

Tam Metin Erişim

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer Yazar: Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Bhumsuk Keam

Tam Metin Erişim

First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid... Yazar: Ravit Geva, Jennifer Mataraza, Osama Rahma, Jason John Luke, Philippe L Bedard, Sarina A Piha-Paul, Angad Singh, Tira J Tan, Darren WT Lim, Cinta Hierro, Toshikiko Doi, Alexander Lesokhin, Javier Otero, Lisa Nardi, Alexandros Xyrafas, Xinhui Chen

Tam Metin Erişim

RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study Yazar: Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Erick Campbell, Amber M Johnson, Sarina A. Piha-Paul, Isabella C. Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam, Vivek Subbiah

Tam Metin Erişim

Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors Yazar: Filip Janku, David S. Hong, Siqing Fu, Sarina A. Piha-Paul, Aung Naing, Gerald S. Falchook, Apostolia M. Tsimberidou, Vanda M. Stepanek, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, Ralph G. Zinner, Russell R. Broaddus, Jennifer J. Wheler, Razelle Kurzrock

Tam Metin Erişim

Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial Yazar: Aung Naing, Funda Meric-Bernstam, Michael Overman, Bettzy Stephen, David S Hong, Sarina A Piha-Paul, Daniel D Karp, Kanwal P Raghav, Dipti Jain, Dilichukwu O Chudy Onwugaje, Abdulrahman Abonofal, Anneleis F Willett, Brandon Smaglo, Ryan W Huey, Gauri R Varadhachary

Tam Metin Erişim

724 Subcutaneous nemvaleukin alfa in combination with pembrolizumab in patients with refractory solid tumors (ARTISTRY-2) Yazar: Aranzazu Manzano, Omid Hamid, Emiliano Calvo, Marc S Ernstoff, Anthony J Olszanski, John Wrangle, Anthony F Shields, Stephen V Liu, Sarina A Piha-Paul, Trisha M Wise-Draper, Yangchun Du, Justin A Call, Shwetha Asha, Ralph Boccia, Angela Tatiana Alistar, Carlos Mayo, Leah Rider

Selinexor in Combination with Carboplatin and Pemetrexed in Patients with Advanced or Metastatic Solid Tumors: Results of an Open-Label, Single-Center, Multi-Arm Phase 1b Study Yazar: Kyaw Z. Thein, Siqing Fu, Filip Janku, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Daniel D. Karp, Jatin Shah, Denái R. Milton, Jing Gong, Selma Sulovic, Lacey McQuinn, Bettzy A. Stephen, Rivka R. Colen, Brett W. Carter, Funda Meric-Bernstam, Aung Naing

Tam Metin Erişim

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma. Yazar: Bert H O'Neil, John M Wallmark, David Lorente, Elena Elez, Judith Raimbourg, Carlos Gomez-Roca, Samuel Ejadi, Sarina A Piha-Paul, Mark N Stein, Albiruni R Abdul Razak, Katia Dotti, Armando Santoro, Roger B Cohen, Marlena Gould, Sanatan Saraf, Karen Stein, Sae-Won Han

Tam Metin Erişim