253 PD1 and LAG3 converge to limit polyfunctionality and systemic immunity by Dario Vignali, Creg Workman, Sasikanth Manne, Lawrence Andrews, E John Wherry

186 Distinct immune signatures predicting clinical response to PD-1 blockade therapy in gynecological cancers revealed by high-dimensional immune profiling by Dmitriy Zamarin, Claire Friedman, Yuki Muroyama, Sasikanth Manne, Alexandar Huang, Divij Mathew, Lakshmi Chilukuri, Allison Greenplate, Takuya Ohtani, John Wherry

310 T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade by Alexander Huang, Claire Friedman, Yuki Muroyama, Sasikanth Manne, Divij Mathew, Lakshmi Chilukuri, Allison Greenplate, Ramin Herati, E John Wherry, Derek Oldridge, Caiyue Xu, Dimitriy Zamarin

1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX by Omar Khan, Sasikanth Manne, E John Wherry, Josephine R Giles, Amy E Baxter, Shin Foong Ngiow, Yinghui Jane Huang, Simone L Park, Jennifer E Wu

Notch transactivates Rheb to maintain the multipotency of TSC-null cells by Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K. Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P. Henske, Fabrice Roegiers, Krinio Giannikou, David J. Kwiatkowski, Hossein Mansouri, Maciej M. Markiewski, Brandon White, Magdalena Karbowniczek

Get full text

579-C Reinvigoration of progenitor-exhausted CD8 T cells by anti-CTLA-4 contributes to the sustained activity of combination checkpoint blockade by Xiaowei Xu, Wei Xu, Alexander Huang, Jeffrey Weber, Andy Minn, Kevin Wang, Tara Mitchell, Sasikanth Manne, Divij Mathew, E John Wherry, Daniel Tenney, Paulina Coutifaris, David Brocks, Sabrina Solis, Nicholas Han, Evgeny Kiner, Chirag Sachar, Sangeeth George, Patrick Yan, Melanie W Kiner, Amy I Laughlin, Shawn Kothari, Josephine R Giles, Rheem Ghinnagow, Cecile Alanio, Ahron Flowers, Ravi K Amaravadi, Giorgos C Karakousis, Lynn M Schuchter, Marcus Buggert, Ramin S Herati

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Sokratis A. Apostolidis, Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Amy E. Baxter, Allison R. Greenplate, Allison R. Greenplate, Cécile Alanio, Cécile Alanio, Cécile Alanio, Mohamed Abdel-Hakeem, Mohamed Abdel-Hakeem, Derek A. Oldridge, Derek A. Oldridge, Derek A. Oldridge, Josephine R. Giles, Josephine R. Giles, Josephine R. Giles, Jennifer E. Wu, Jennifer E. Wu, Jennifer E. Wu, Zeyu Chen, Zeyu Chen, Yinghui Jane Huang, Yinghui Jane Huang, Jonathan Belman, Jonathan Belman, Ajinkya Pattekar, Ajinkya Pattekar, Sasikanth Manne, Sasikanth Manne, Oliva Kuthuru, Oliva Kuthuru, Jeanette Dougherty, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Alexander C. Huang, Alexander C. Huang, Laura A. Vella, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Scott E. Hensley, Lubica Rauova, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Mortimer Poncz, Charles S. Abrams, E. John Wherry, E. John Wherry, E. John Wherry, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck

Get full text