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BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability by Jennings, L, Schiedel, M, Hewings, D, Picaud, S, Laurin, C, Bruno, P, Bluck, J, Scorah, A, See, L, Reynolds, J, Moroglu, M, Mistry, I, Hicks, A, Guzanov, P, Clayton, J, Evans, C, Stazi, G, Biggin, P, Mapp, A, Hammond, E, Humphreys, P, Filippakopoulos, P, Conway, S
Published 2018Journal article -
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Controlling intramolecular interactions in the design of selective, high-affinity, ligands for the CREBBP Bromodomain by Brand, M, Clayton, J, Moroglu, M, Schiedel, M, Picaud, S, Buck, J, Skwarska, A, Bolland, H, Chan, A, Laurin, C, Scorah, A, See, L, Rooney, T, Andrews, K, Fedorov, O, Perell, G, Kalra, P, Vinh, K, Cortopassi, W, Heitel, P, Christensen, K, Cooper, R, Paton, R, Pomerantz, W, Biggin, P, Hammond, E, Filippakopoulos, P, Conway, S
Published 2021Journal article