A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation by Guang Yang, Danielle S. Murashige, Sean J. Humphrey, David E. James

Get full text

Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion by Francesca Sacco, Sean J. Humphrey, Jürgen Cox, Marcel Mischnik, Anke Schulte, Thomas Klabunde, Matthias Schäfer, Matthias Mann

Get full text

PhosR enables processing and functional analysis of phosphoproteomic data by Hani Jieun Kim, Taiyun Kim, Nolan J. Hoffman, Di Xiao, David E. James, Sean J. Humphrey, Pengyi Yang

Get full text

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion by Elise J. Needham, Sean J. Humphrey, Kristen C. Cooke, Daniel J. Fazakerley, Xiaowen Duan, Benjamin L. Parker, David E. James

Get full text

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation by Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James

Get full text

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies. by Westa Domanova, James R Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J Fazakerley, Sean J Humphrey, David E James, Zdenka Kuncic

Get full text

Corrigendum to ‘ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation’ [Molecular Metabolism 25 (2019) p.83–94] by Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James

Get full text

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans by Lenka Halova, David Cobley, Mirita Franz-Wachtel, Tingting Wang, Kaitlin R. Morrison, Karsten Krug, Nicolas Nalpas, Boris Maček, Iain M. Hagan, Sean J. Humphrey, Janni Petersen

Get full text

µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics by Denys Oliinyk, Andreas Will, Felix R Schneidmadel, Maximilian Böhme, Jenny Rinke, Andreas Hochhaus, Thomas Ernst, Nina Hahn, Christian Geis, Markus Lubeck, Oliver Raether, Sean J Humphrey, Florian Meier

Get full text

The genetic and dietary landscape of the muscle insulin signalling network by Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James

Get full text

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells by Ariadna Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, Elise J. Needham, David E. James, Terrance G. Johns, Bryan W. Day, Michael Kassiou, Pengyi Yang, Lenka Munoz

Get full text

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis by Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield

Get full text

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance by Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, Xiaowen Duan, Elise J. Needham, Alexis Díaz-Vegas, Søren Madsen, Dougall M. Norris, Amber S. Shun-Shion, James R. Krycer, James G. Burchfield, Pengyi Yang, Mark R. Wade, Joseph T. Brozinick, David E. James, Sean J. Humphrey

Get full text

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism by James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James

Get full text

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet by Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede

Get full text

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet by Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede

Get full text

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt by Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James

Get full text

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance by Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James

Get full text