Colorectal cancer and genetic alterations in the Wnt pathway. by Segditsas, S, Tomlinson, I

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. by Segditsas, S, Sieber, O, Rowan, A, Setien, F, Neale, K, Phillips, R, Ward, R, Esteller, M, Tomlinson, I

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation. by Lessi, F, Beggs, A, de Palo, M, Anti, M, Macarone Palmieri, R, Francesconi, S, Gomes, V, Bevilacqua, G, Tomlinson, I, Segditsas, S

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. by Thirlwell, C, Howarth, K, Segditsas, S, Guerra, G, Thomas, H, Phillips, R, Talbot, I, Gorman, M, Novelli, MR, Sieber, O, Tomlinson, I

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation. by Francesca Lessi, Andrew Beggs, Mariagrazia de Palo, Marcello Anti, Raffaele Macarone Palmieri, Simona Francesconi, Vito Gomes, Generoso Bevilacqua, Ian Tomlinson, Stefania Segditsas

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Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. by Jones, A, Thirlwell, C, Howarth, K, Graham, T, Chambers, W, Segditsas, S, Page, K, Phillips, R, Thomas, H, Sieber, O, Sawyer, E, Tomlinson, I

The C-terminus of Apc does not influence intestinal adenoma development or progression by Lewis, A, Davis, H, Deheragoda, M, Pollard, P, Nye, E, Jeffery, R, Segditsas, S, East, P, Poulsom, R, Stamp, G, Wright, N, Tomlinson, I

The C-terminus of Apc does not influence intestinal adenoma development or progression. by Lewis, A, Davis, H, Deheragoda, M, Pollard, P, Nye, E, Jeffery, R, Segditsas, S, East, P, Poulsom, R, Stamp, G, Wright, N, Tomlinson, I

Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5 by Lewis, A, Segditsas, S, Deheragoda, M, Pollard, P, Jeffery, R, Nye, E, Lockstone, H, Davis, H, Clark, S, Stamp, G, Poulsom, R, Wright, N, Tomlinson, I

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. by Lewis, A, Segditsas, S, Deheragoda, M, Pollard, P, Jeffery, R, Nye, E, Lockstone, H, Davis, H, Clark, S, Stamp, G, Poulsom, R, Wright, N, Tomlinson, I

APC and the three-hit hypothesis. by Segditsas, S, Rowan, A, Howarth, K, Jones, A, Leedham, S, Wright, N, Gorman, P, Chambers, W, Domingo, E, Roylance, R, Sawyer, E, Sieber, O, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. by Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation by McDonald, S, Jeffery, R, Humphries, A, Leedham, S, Graham, T, Segditsas, S, Lewis, A, Nicholson, A, Bamba, S, Rodriguez-Justo, M, Novelli, M, Jankowski, J, Wright, N, Poulsom, R

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts by Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 by Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. by Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. by Segditsas, S, Sieber, O, Deheragoda, M, East, P, Rowan, A, Jeffery, R, Nye, E, Clark, S, Spencer-Dene, B, Stamp, G, Poulsom, R, Suraweera, N, Silver, A, Ilyas, M, Tomlinson, I

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. by Pollard, P, Deheragoda, M, Segditsas, S, Lewis, A, Rowan, A, Howarth, K, Willis, L, Nye, E, McCart, A, Mandir, N, Silver, A, Goodlad, R, Stamp, G, Cockman, M, East, P, Spencer-Dene, B, Poulsom, R, Wright, N, Tomlinson, I

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. by Sieber, O, Segditsas, S, Knudsen, A, Zhang, J, Luz, J, Rowan, A, Spain, S, Thirlwell, C, Howarth, K, Jaeger, E, Robinson, J, Volikos, E, Silver, A, Kelly, G, Aretz, S, Frayling, I, Hutter, P, Dunlop, M, Guenther, T, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. by Sakthianandeswaren, A, Christie, M, D'Andreti, C, Tsui, C, Jorissen, R, Li, S, Fleming, N, Gibbs, P, Lipton, L, Malaterre, J, Ramsay, R, Phesse, T, Ernst, M, Jeffery, R, Poulsom, R, Leedham, S, Segditsas, S, Tomlinson, I, Bernhard, O, Simpson, R, Walker, F, Faux, M, Church, N, Catimel, B, Flanagan, D