Checkpoint Blockade in Cancer Immunotherapy: Squaring the Circle by Maria A.V. Marzolini, Sergio A. Quezada, Karl S. Peggs

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The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019 by Jerome Galon, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi

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Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c1 by Rodrigo Pacheco, Sergio A. Quezada, Alexis M. Kalergis, María Inés Becker, Jorge Ferreira, Alfredo E. De Ioannes

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Correction: Corrigendum: Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis by Isabel Ohs, Maries van den Broek, Kathrin Nussbaum, Christian Münz, Sebastian J. Arnold, Sergio A. Quezada, Sonia Tugues, Burkhard Becher

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Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis by Isabel Ohs, Maries van den Broek, Kathrin Nussbaum, Christian Münz, Sebastian J. Arnold, Sergio A. Quezada, Sonia Tugues, Burkhard Becher

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Urokinase-type plasminogen activator (uPA) regulates invasion and matrix remodelling in colorectal cancer by Auxtine Micalet, Luke J. Tappouni, Katarzyna Peszko, Despoina Karagianni, Ashley Lam, John R. Counsell, Sergio A. Quezada, Emad Moeendarbary, Umber Cheema

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Induction of islet autoimmunity to defective ribosomal product of the insulin gene as neoantigen after anti-cancer immunotherapy leading to autoimmune diabetes by Rene van Tienhoven, Rene van Tienhoven, Diahann T. S. L. Jansen, Miso Park, John C. Williams, James Larkin, Sergio A. Quezada, Bart O. Roep

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Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma by Lydia Lee, Nouf Alrasheed, Garima Khandelwal, Evelyn Fitzsimons, Huw Richards, William Wilson, Selina J. Chavda, Jake Henry, Jake Henry, Lucia Conde, Marc Robert De Massy, Marc Robert De Massy, Marc Robert De Massy, Melody Chin, Daria Galas-Filipowicz, Javier Herrero, Benny Chain, Sergio A. Quezada, Sergio A. Quezada, Kwee Yong

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Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells by Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser

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1312 Identification and validation of immunogenic clonal neoantigens for personalized therapies by Andrew Craig, Martin Forster, Samra Turajlic, Sergio A Quezada, Katy Newton, Karl Peggs, Fong Chan, Karen Matthews, Theres Oakes, Gareth Wilson, Elizabeth Larose Cadieux, Max Salm, Hugh O’Brien

Pan-cancer deconvolution of tumour composition using DNA methylation by Ankur Chakravarthy, Andrew Furness, Kroopa Joshi, Ehsan Ghorani, Kirsty Ford, Matthew J. Ward, Emma V. King, Matt Lechner, Teresa Marafioti, Sergio A. Quezada, Gareth J. Thomas, Andrew Feber, Tim R. Fenton

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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin by Claudia Garcia-Diaz, Anni Pöysti, Elisabetta Mereu, Melanie P. Clements, Lucy J. Brooks, Felipe Galvez-Cancino, Simon P. Castillo, Wenhao Tang, Gordon Beattie, Lilas Courtot, Sara Ruiz, Federico Roncaroli, Yinyin Yuan, Samuel Marguerat, Sergio A. Quezada, Holger Heyn, Simona Parrinello

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437 Optimised achilles VELOSTM process 2b manufacturing platform generates a significant dose boost of reactive CD8 and CD4 clonal neoantigen-reactive T cells for the treatment of... by Sergio A Quezada, Katy Newton, Monica Sassi, Sandro Gomez, Evi Rologi, Meghan Madigan, Joanne Tang, Sarah Thirkell, Samuel Jide Banwo, Temi Ogunleye, Sophie McKeeman, Claire Law, Unnaamalai Meyyappan, Eleni Kotsiou, Theres Oakes, Miha Kosmac, Luke Goodsell, Connor Carolan, Justin Ahern, Tim Hillyer, Bongi Ndlovu, Henrieta Fraser, Edward Samuel

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity by Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton

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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma by Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolás Núñez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher

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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 3rd–5th, 2020, Italy) by Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada, Michele W. L. Teng, Giorgio Trinchieri, Alessandro Testori, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

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ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation by James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. Quezada, Clare E. Futter, Alex Von Kriegsheim, Walter Kolch, Borivoj Vojnovic, Jeremy G. Carlton, Tony Ng

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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd – 4th, 2021, Italy) by Paolo A. Ascierto, Sanjiv S. Agarwala, Christian Blank, Corrado Caracò, Richard D. Carvajal, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Jean-Jacques Grob, Omid Hamid, Michelle Krogsgaard, Roger S. Lo, Amanda W. Lund, Gabriele Madonna, Olivier Michielin, Bart Neyns, Iman Osman, Solange Peters, Poulikos I. Poulikakos, Sergio A. Quezada, Bradley Reinfeld, Laurence Zitvogel, Igor Puzanov, Magdalena Thurin

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Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference by Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R.V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti

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