Next-Generation Sequencing in Order to Better Characterize a BRCA Variant of Uncertain Significance by Steven Sorscher, Shakti Ramkissoon

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Comparison of programmed death-ligand 1 protein expression between primary and metastatic lesions in patients with lung cancer by Lajos Pusztai, Richard Huang, Shakti Ramkissoon, Jeffrey S Ross, Konstantinos Syrigos, Myrto K Moutafi, Weiwei Tao, James Haberberger, Ioannis A Vathiotis

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Is HER2-Low a New Clinical Entity or Merely a Biomarker for an Antibody Drug Conjugate? by Heidi Ko, Rebecca A. Previs, Kyle C. Strickland, Jonathan Klein, Brian Caveney, Chiara Chiruzzi, Marcia Eisenberg, Eric A. Severson, Shakti Ramkissoon, Kamal S. Saini

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Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in advanced non-small cell lung cancer by Idoko Salifu, Navneet Singh, Maria Berraondo, Jordi Remon, Stephanie Salifu, Eric Severson, Angela Quintana, Sandra Peiró, Shakti Ramkissoon, Laura Vidal, Isagani Chico, Kamal S. Saini

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1455 Characterization of gene expression signatures of tumor immunogenicity and cellular proliferation from murine cancer models grown in vitro and in vivo by Marcia Eisenberg, Shakti Ramkissoon, Mary K Nesline, Kyle C Strickland, Zachary D Wallen, Taylor J Jensen, Brian Caveney, Prasanth Reddy, Eric A Severson, Sheri Barnes, Scott C Wise

PD-L1 Expression by RNA-Sequencing in Non-Small Cell Lung Cancer: Concordance with Immunohistochemistry and Associations with Pembrolizumab Treatment Outcomes by Mary K. Nesline, Rebecca A. Previs, Grace K. Dy, Lei Deng, Yong Hee Lee, Paul DePietro, Shengle Zhang, Nathan Meyers, Eric Severson, Shakti Ramkissoon, Sarabjot Pabla, Jeffrey M. Conroy

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O09: Potential germline variants are frequently identified when performing comprehensive genomic profiling of solid tumors* by Taylor Jensen, Dagny Noeth, Amy Cronister, Paul DePietro, Roger Klein, Mary Nesline, Sarabjot Pabla, Anjen Chenn, Shengle Zhang, Jonathan Klein, Sarah Howarth, Eric Severson, Shakti Ramkissoon, Marcia Eisenberg, Prasanth Reddy, Jeffrey Conroy

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Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy by Paulina Czajka-Francuz, Maria J. Prendes, Arun Mankan, Ángela Quintana, Sarabjot Pabla, Shakti Ramkissoon, Taylor J. Jensen, Sandra Peiró, Eric A. Severson, Bhagelu R. Achyut, Laura Vidal, Martine Poelman, Kamal S. Saini, Kamal S. Saini

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Clinically Advanced Pheochromocytomas and Paragangliomas: A Comprehensive Genomic Profiling Study by Gennady Bratslavsky, Ethan S. Sokol, Michael Daneshvar, Andrea Necchi, Oleg Shapiro, Joseph Jacob, Nick Liu, Tom S. Sanford, Ruben Pinkhasov, Hanan Goldberg, Jonathan K. Killian, Shakti Ramkissoon, Eric A. Severson, Richard S. P. Huang, Natalie Danziger, Mehdi Mollapour, Jeffrey S. Ross, Karel Pacak

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1499 Molecular and immune profiling of lobular-enriched versus non-lobular invasive breast cancers by Sarabjot Pabla, Marcia Eisenberg, Shengle Zhang, Shakti Ramkissoon, Kamal S Saini, Mary K Nesline, Jeffrey M Conroy, Kyle C Strickland, Heidi Ko, Rebecca A Previs, Zachary D Wallen, Jennifer B Jackson, Taylor J Jensen, Brian Caveney, Prasanth Reddy, Eric A Severson

513 Comprehensive genomic and immune profiling of ALK fusion-positive and negative lung adenocarcinomas by Sarabjot Pabla, Marcia Eisenberg, Shengle Zhang, Shakti Ramkissoon, Kamal S Saini, Mary K Nesline, Jeffrey M Conroy, Kyle C Strickland, Heidi Ko, Rebecca A Previs, Zachary D Wallen, Taylor J Jensen, Brian Caveney, Prasanth Reddy, Eric A Severson, Pratheesh Sathyan, Marc AT Muskavitch, Ken Culver

176 Immune microenvironment of primary versus metastatic melanoma of the brain by Sarabjot Pabla, Marcia Eisenberg, Erik Van Roey, Shuang Gao, Shengle Zhang, Shakti Ramkissoon, Mary K Nesline, Maria-Fernanda Senosain, Jeffrey M Conroy, Kyle C Strickland, Heidi Ko, Rebecca A Previs, Taylor J Jensen, Brian Caveney, Eric A Severson, Stephanie B Hastings, Robert Seager

183 Comprehensive genomic and immune profiling (CGIP) reveals a distinct genomic and immune gene expression profile for younger patients with non-small cell lung cancer (NSCLC) by Sarabjot Pabla, Shengle Zhang, Shakti Ramkissoon, Kamal S Saini, Mary K Nesline, Jeffrey M Conroy, Kyle C Strickland, Heidi Ko, Rebecca A Previs, Zachary D Wallen, Jennifer B Jackson, Taylor J Jensen, Brian Caveney, Prasanth Reddy, Eric A Severson, Stephanie B Hastings, Pratheesh Sathyan

175 Metastatic triple negative breast cancer has distinct tumor immune landscape by Sarabjot Pabla, Marcia Eisenberg, Shipra Gandhi, Erik Van Roey, Shuang Gao, Shengle Zhang, Shakti Ramkissoon, Mary K Nesline, Maria-Fernanda Senosain, Jeffrey M Conroy, Kyle C Strickland, Heidi Ko, Rebecca A Previs, Taylor J Jensen, Brian Caveney, Eric A Severson, Stephanie B Hastings, Robert Seager

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues. by Justin M Craig, Natalie Vena, Shakti Ramkissoon, Ahmed Idbaih, Shaun D Fouse, Memet Ozek, Aydin Sav, D Ashley Hill, Linda R Margraf, Charles G Eberhart, Mark W Kieran, Andrew D Norden, Patrick Y Wen, Massimo Loda, Sandro Santagata, Keith L Ligon, Azra H Ligon

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184 Distinct immunotherapy immune response phenotypes in non-small cell lung cancer present with unique genomic alteration profiles by Sarabjot Pabla, Marcia Eisenberg, RJ Seager, Erik Van Roey, Shuang Gao, Shengle Zhang, Shakti Ramkissoon, Mary K Nesline, Maria-Fernanda Senosain, Jeffrey M Conroy, Kyle C Strickland, Rebecca A Previs, Zachary D Wallen, Taylor J Jensen, Brian Caveney, Prasanth Reddy, Eric A Severson, Stephanie B Hastings

Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer by R. J. Seager, Maria-Fernanda Senosain, Erik Van Roey, Shuang Gao, Paul DePietro, Mary K. Nesline, Durga Prasad Dash, Shengle Zhang, Heidi Ko, Stephanie B. Hastings, Kyle C. Strickland, Rebecca A. Previs, Taylor J. Jensen, Marcia Eisenberg, Brian J. Caveney, Eric A. Severson, Shakti Ramkissoon, Jeffrey M. Conroy, Sarabjot Pabla

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Primary Adult Retroperitoneal Sarcoma: A Comprehensive Genomic Profiling Study by Andrea Necchi, Giuseppe Basile, Filippo Pederzoli, Marco Bandini, Petros Grivas, Gennady Bratslavsky, Philippe E. Spiess, J. Keith Killian, Douglas I. Lin, Erik Williams, Shakti Ramkissoon, Eric A. Severson, Brian M. Alexander, Jeffrey Venstrom, Prasanth Reddy, Kimberley McGregor, Julia A. Elvin, Alexa B. Schrock, Dean V. Pavlick, Dexter X. Jin, Sally E. Trabucco, Natalie Danzinger, Jeffrey S. Ross

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