Alex K. Shalek
Alex K. Shalek, a biomedical engineer, is the Director of the Institute for Medical Engineering and Science (IMES) and the J. W. Kieckhefer Professor in IMES and the Department of Chemistry at the Massachusetts Institute of Technology. He is an Extramural Member of the Koch Institute for Integrative Cancer Research at MIT. Additionally, he is a Member of the Ragon Institute, an Institute Member of the Broad Institute, an Assistant in Immunology at Massachusetts General Hospital, and an Instructor in Health Sciences and Technology at Harvard Medical School. The multi-disciplinary research of the Shalek Lab aims to create and implement broadly-applicable methods to study and engineer cellular responses in tissues, to drive biological discovery and improve prognostics, diagnostics, and therapeutics for autoimmune, infectious, and cancerous diseases. Shalek and his lab are best known for their work in single-cell genomics and for studying a number of devastating, but difficult to study, human diseases with partners around the world. Provided by Wikipedia
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Evolution and Diversity of Immune Responses during Acute HIV Infection by Kazer, Samuel W, Walker, Bruce D, Shalek, Alex K
Published 2022
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Computational Methods for Single-Cell RNA Sequencing by Hie, Brian, Peters, Joshua, Nyquist, Sarah K, Shalek, Alex K, Berger, Bonnie, Bryson, Bryan D
Published 2021
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Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli by Gat-Viks, Irit, Chevrier, Nicolas, Wilentzik, Roni, Eisenhaure, Thomas, Raychowdhury, Raktima, Steuerman, Yael, Shalek, Alex K., Hacohen, Nir, Amit, Ido, Regev, Aviv
Published 2014
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Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform by Gerdemann, Ulrike, Fleming, Ryan A, Kaminski, James, McGuckin, Connor, Rui, Xianliang, Lane, Jennifer F, Keskula, Paula, Cagnin, Lorenzo, Shalek, Alex K, Tkachev, Victor, Kean, Leslie S
Published 2022
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Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity by Zhivaki, Dania, Borriello, Francesco, Chow, Ohn A, Doran, Benjamin, Fleming, Ira, Theisen, Derek J, Pallis, Paris, Shalek, Alex K, Sokol, Caroline L, Zanoni, Ivan, Kagan, Jonathan C
Published 2022
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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data by Finak, Greg, McDavid, Andrew, Yajima, Masanao, Deng, Jingyuan, Gersuk, Vivian, Prlic, Martin, Gottardo, Raphael, Slichter, Chloe K., Miller, Hannah W., McElrath, M. Juliana, Linsley, Peter S., Shalek, Alex
Published 2015
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Functional compensation precedes recovery of tissue mass following acute liver injury by Walesky, Chad M, Kolb, Kellie E, Winston, Carolyn L, Henderson, Jake, Kruft, Benjamin, Fleming, Ira, Ko, Sungjin, Monga, Satdarshan P, Mueller, Florian, Apte, Udayan, Shalek, Alex K, Goessling, Wolfram
Published 2022
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Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection by Wilk, Aaron J., Marceau, Joshua O., Kazer, Samuel W., Fleming, Ira, Miao, Vincent N., Galvez-Reyes, Jennyfer, Kimata, Jason T., Shalek, Alex K., Holmes, Susan, Overbaugh, Julie, Blish, Catherine A.
Published 2024
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Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response by Rodel, Hylton E, Ferreira, Isabella ATM, Ziegler, Carly GK, Ganga, Yashica, Bernstein, Mallory, Hwa, Shi-Hsia, Nargan, Kievershen, Lustig, Gila, Kaplan, Gilla, Noursadeghi, Mahdad, Shalek, Alex K, Steyn, Adrie JC, Sigal, Alex
Published 2022
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Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells by Pae, Juhee, Ersching, Jonatan, Castro, Tiago BR, Schips, Marta, Mesin, Luka, Allon, Samuel J, Ordovas-Montanes, Jose, Mlynarczyk, Coraline, Melnick, Ari, Efeyan, Alejo, Shalek, Alex K, Meyer-Hermann, Michael, Victora, Gabriel D
Published 2022
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Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells by Jiang, Ruoyi, Meng, Hailong, Raddassi, Khadir, Fleming, Ira, Hoehn, Kenneth B, Dardick, Kenneth R, Belperron, Alexia A, Montgomery, Ruth R, Shalek, Alex K, Hafler, David A, Kleinstein, Steven H, Bockenstedt, Linda K
Published 2022
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Cellular and transcriptional diversity over the course of human lactation by Nyquist, Sarah K, Gao, Patricia, Haining, Tessa KJ, Retchin, Michael R, Golan, Yarden, Drake, Riley S, Kolb, Kellie, Mead, Benjamin E, Ahituv, Nadav, Martinez, Micaela E, Shalek, Alex K, Berger, Bonnie, Goods, Brittany A
Published 2022
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IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease by Buchheit, Kathleen M, Dwyer, Daniel F, Ordovas-Montanes, Jose, Katz, Howard R, Lewis, Erin, Vukovic, Marko, Lai, Juying, Bankova, Lora G, Bhattacharyya, Neil, Shalek, Alex K, Barrett, Nora A, Boyce, Joshua A, Laidlaw, Tanya M
Published 2021
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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity by Mana, Miyeko D, Hussey, Amanda M, Tzouanas, Constantine N, Imada, Shinya, Barrera Millan, Yesenia, Bahceci, Dorukhan, Saiz, Dominic R, Webb, Anna T, Lewis, Caroline A, Carmeliet, Peter, Mihaylova, Maria M, Shalek, Alex K, Yilmaz, Ömer H
Published 2021
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