Editorial: Genomic Instability and Neurodegeneration by Julia Fuchs, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Sherif F. El-Khamisy, Sherif F. El-Khamisy

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DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat by Harvey Boughey, Mateusz Jurga, Sherif F. El-Khamisy

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ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. by Meryem Alagoz, Shih-Chieh Chiang, Abhishek Sharma, Sherif F El-Khamisy

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Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer by Mohamed K. Hassan, Amr A. Waly, Waheba Elsayed, Sarah Keshk, Walaa Ramadan Allam, Sherif F. El-khamisy

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Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues by Francis M. Barnieh, Sebastian P. Galuska, Paul M. Loadman, Simon Ward, Robert A. Falconer, Sherif F. El-Khamisy

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Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugsResearch in context by Mohamed Tharwat Hegazy, Walaa Ramadan Allam, Mohamed A. Hussein, Naguib Zoheir, Luca Quartuccio, Sherif F. El-Khamisy, Gaafar Ragab

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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection by Angela E. M. Ibler, Mohamed ElGhazaly, Kathryn L. Naylor, Natalia A. Bulgakova, Sherif F. El-Khamisy, Daniel Humphreys

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High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes by Mai A. Rahmoon, Reem A. Elghaish, Aya A. Ibrahim, Zina Alaswad, Mohamed Z. Gad, Sherif F. El-Khamisy, Menattallah Elserafy

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High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice by Mohamed E. Ashour, Walaa Allam, Waheba Elsayed, Reham Atteya, Menattallah Elserafy, Sameh Magdeldin, Mohamed K. Hassan, Sherif F. El-Khamisy

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UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis by Chunyan Liao, Ryan Beveridge, Jessica J.R. Hudson, Jacob D. Parker, Shih-Chieh Chiang, Swagat Ray, Mohamed E. Ashour, Ian Sudbery, Mark J. Dickman, Sherif F. El-Khamisy

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Genome-wide association study for systemic lupus erythematosus in an egyptian population by Ashraf A. Elghzaly, Celi Sun, Loren L. Looger, Misa Hirose, Mohamed Salama, Noha M. Khalil, Mervat Essam Behiry, Mohamed Tharwat Hegazy, Mohamed Ahmed Hussein, Mohamad Nabil Salem, Ehab Eltoraby, Ziyad Tawhid, Mona Alwasefy, Walaa Allam, Iman El-Shiekh, Menattallah Elserafy, Anwar Abdelnaser, Sara Hashish, Nourhan Shebl, Abeer Abdelmonem Shahba, Amira Elgirby, Amina Hassab, Khalida Refay, Hanan Mohamed El-Touchy, Ali Youssef, Fatma Shabacy, Abdelkader Ahmed Hashim, Asmaa Abdelzaher, Emad Alshebini, Dalia Fayez, Samah A. El-Bakry, Mona H. Elzohri, Eman Nagiub Abdelsalam, Sherif F. El-Khamisy, Sherif F. El-Khamisy, Sherif F. El-Khamisy, Saleh Ibrahim, Gaafar Ragab, Swapan K. Nath

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Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma by Natasha Carmell, Ola Rominiyi, Katie N. Myers, Connor McGarrity-Cottrell, Aurelie Vanderlinden, Nikita Lad, Eva Perroux-David, Sherif F. El-Khamisy, Malee Fernando, Katherine G. Finegan, Stephen Brown, Spencer J. Collis

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Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits by Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, Mimoun Azzouz

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A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3 by Hannah M. Southam, Thomas W. Smith, Rhiannon L. Lyon, Chunyan Liao, Clare R. Trevitt, Laurence A. Middlemiss, Francesca L. Cox, Jonathan A. Chapman, Sherif F. El-Khamisy, Michael Hippler, Michael P. Williamson, Peter J.F. Henderson, Robert K. Poole

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TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts by John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan

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A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN by Abdelghani Mazouzi, Alexey Stukalov, André C. Müller, Doris Chen, Marc Wiedner, Jana Prochazkova, Shih-Chieh Chiang, Michael Schuster, Florian P. Breitwieser, Andreas Pichlmair, Sherif F. El-Khamisy, Christoph Bock, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou

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