Message from the new Co-Editor-in-Chief by Shin-ichiro Imai

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NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] by Sean Johnson, Shin–ichiro Imai

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Friends and foes: Extracellular vesicles in aging and rejuvenation by Brian V. Lananna, Shin‐ichiro Imai

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging by Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai

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NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice by Kelly L. Stromsdorfer, Shintaro Yamaguchi, Myeong Jin Yoon, Anna C. Moseley, Michael P. Franczyk, Shannon C. Kelly, Nathan Qi, Shin-ichiro Imai, Jun Yoshino

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The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs by Fiorella Ghisays, Cynthia S. Brace, Shawn M. Yackly, Hyock Joo Kwon, Kathryn F. Mills, Elena Kashentseva, Igor P. Dmitriev, David T. Curiel, Shin-ichiro Imai, Tom Ellenberger

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NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice by Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte

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