Does the SARS-CoV-2 spike really have an Achilles heel? by Shiv Pillai

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Clonally expanded cytotoxic CD4+ T cells and the pathogenesis of IgG4-related disease by Hamid Mattoo, John H. Stone, Shiv Pillai

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Editorial: Cytotoxic CD4+ T Cells in Viral Infections by Chansavath Phetsouphanh, Shiv Pillai, John J. Zaunders, John J. Zaunders

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Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain by Vinay S. Mahajan, Ezana Demissie, Hamid Mattoo, Vinay Viswanadham, Ajit Varki, Robert Morris, Shiv Pillai

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The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development by Faisal Alsufyani, Hamid Mattoo, Dawang Zhou, Annaiah Cariappa, Denille Van Buren, Hanno Hock, Joseph Avruch, Shiv Pillai

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M89V Sialic acid Acetyl Esterase (SIAE) and all other non-synonymous common variants of this gene are catalytically normal. by Vasant Chellappa, Kendra N Taylor, Kathryn Pedrick, Carlos Donado, Ilka Arun Netravali, Khaleda Haider, Annaiah Cariappa, Natasha F Dalomba, Shiv Pillai

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B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers by Vinay S. Mahajan, Hamid Mattoo, Na Sun, Vinayak Viswanadham, Grace J. Yuen, Hugues Allard-Chamard, Maimuna Ahmad, Samuel J. H. Murphy, Annaiah Cariappa, Yesim Tuncay, Shiv Pillai

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Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis by Damian R. Plichta, Juhi Somani, Matthieu Pichaud, Zachary S. Wallace, Ana D. Fernandes, Cory A. Perugino, Harri Lähdesmäki, John H. Stone, Hera Vlamakis, Daniel C. Chung, Dinesh Khanna, Shiv Pillai, Ramnik J. Xavier

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Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection by Yuta Asano, Joe Daccache, Dharmendra Jain, Kichul Ko, Andrew Kinloch, Margaret Veselits, Donald Wolfgeher, Anthony Chang, Michelle Josephson, Patrick Cunningham, Anat Tambur, Aly A. Khan, Shiv Pillai, Anita S. Chong, Marcus R. Clark

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Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis by David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai, Dinesh Khanna

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Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome by Naoki Kaneko, Hu Chen, Cory A. Perugino, Takashi Maehara, Ryusuke Munemura, Shiho Yokomizo, Junsei Sameshima, Thomas J. Diefenbach, Katherine R. Premo, Akira Chinju, Yuka Miyahara, Mizuki Sakamoto, Masafumi Moriyama, John H. Stone, Seiji Nakamura, Shiv Pillai

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B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma by Claudia Minici, Elena Rigamonti, Marco Lanzillotta, Antonella Monno, Lucrezia Rovati, Takashi Maehara, Naoki Kaneko, Vikram Deshpande, Maria Pia Protti, Lucia De Monte, Cristina Scielzo, Stefano Crippa, Paolo Giorgio Arcidiacono, Erica Dugnani, Lorenzo Piemonti, Massimo Falconi, Shiv Pillai, Angelo A. Manfredi, Emanuel Della-Torre

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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

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Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19 by Hugues Allard-Chamard, Naoki Kaneko, Alice Bertocchi, Na Sun, Julie Boucau, Hsiao-Hsuan Kuo, Jocelyn R. Farmer, Cory Perugino, Vinay S. Mahajan, Samuel J.H. Murphy, Katherine Premo, Thomas Diefenbach, Musie Ghebremichael, Grace Yuen, Alekhya Kotta, Zafer Akman, Mathias Lichterfeld, Bruce D. Walker, Xu G. Yu, Masafumi Moriyama, Takashi Maehara, Seiji Nakamura, John H. Stone, Robert F. Padera, Shiv Pillai

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Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis by Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response in adults with predominantly antibody deficiency by Anna M. Zhang, MD, Ahmed Elmoursi, MD, MPH, Daniel V. DiGiacomo, MD, MPH, Baijun Zhou, MHS, Megha Tandon, BA, Joseph S. Hong, BS, Nancy J. Yang, BS, Mei-Sing Ong, PhD, Anand S. Dighe, MD, PhD, Cristhian Berrios, MD, Mark C. Poznansky, MD, PhD, Anthony J. Iafrate, MD, PhD, Vivek Naranbhai, PhD, MB, ChB, Alejandro Balazs, PhD, Shiv Pillai, MBBS, PhD, Jocelyn R. Farmer, MD, PhD, Sara Barmettler, MD

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