The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. by Sieber, O, Tomlinson, I, Lamlum, H

Tissue, cell and stage specificity of (epi)mutations in cancers. by Sieber, O, Tomlinson, SR, Tomlinson, I

Genomic instability--the engine of tumorigenesis? by Sieber, O, Heinimann, K, Tomlinson, I

Genomic stability and tumorigenesis. by Sieber, O, Heinimann, K, Tomlinson, I

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy? by Sieber, O, Lipton, L, Heinimann, K, Tomlinson, I

An update on the genetics of colorectal cancer. by Kemp, Z, Thirlwell, C, Sieber, O, Silver, A, Tomlinson, I

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer. by Tomlinson, I, Houlston, R, Montgomery, G, Sieber, O, Dunlop, MG

Evidence of monoclonality in dysplasia in ulcerative colitis by Leedham, S, Maia, L, Preston, S, Stuart, M, Sieber, O, Tomlinson, I, Wright, N

Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype. by Lipton, L, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Woodford-Richens, K

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. by Lipton, L, Fleischmann, C, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Houlston, R

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. by Parker, A, Sieber, O, Shi, C, Hua, L, Takao, M, Tomlinson, I, Eshleman, JR

Evaluation of PIK3CA mutation as a predictor of benefit from NSAID therapy in colorectal cancer by Church, D, Domingo, E, Sieber, O, Ramamoorthy, R, Davidson, B, Kerr, D, Midgley, R, Tomlinson, I

Effect of SNP haplotypes associated with colorectal cancer risk on outcome by Walther, A, Sieber, O, Domingo, E, Jaeger, E, Johnstone, E, Orntoft, T, Aaltonen, L, Kerr, D, Tomlinson, I

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. by Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. by Segditsas, S, Sieber, O, Rowan, A, Setien, F, Neale, K, Phillips, R, Ward, R, Esteller, M, Tomlinson, I

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. by Suraweera, N, Latchford, A, McCart, A, Rogers, P, Spain, S, Sieber, O, Phillips, R, Tomlinson, I, Silver, A

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data. by Yau, C, Mouradov, D, Jorissen, R, Colella, S, Mirza, G, Steers, G, Harris, A, Ragoussis, J, Sieber, O, Holmes, C

Prognostic value of chronic inflammatory cell infiltrates in Dukes stage B and C colorectal cancer. by Christie, M, Prakash, S, Jorissen, R, Sakthianandeswaren, A, Gibbs, P, Lipton, L, Desai, J, Tie, J, Kerr, D, Sieber, O

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. by Crabtree, M, Sieber, O, Lipton, L, Hodgson, S, Lamlum, H, Thomas, H, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. by Domingo, E, Church, D, Sieber, O, Ramamoorthy, R, Yanagisawa, Y, Johnstone, E, Davidson, B, Kerr, D, Tomlinson, I, Midgley, R