Dissecting mammalian immunity through mutation. by Siggs, O

Dissecting mammalian immunity through mutation by Siggs, O

The BTB-ZF transcription factors. by Siggs, O, Beutler, B

Forward genetic analysis of mammalian immunity by Siggs, O, Owen Siggs

Tracing the action of IL-2 in tolerance to islet-specific antigen. by Liston, A, Siggs, O, Goodnow, C

Unravelling the association of partial T-cell immunodeficiency and immune dysregulation. by Liston, A, Enders, A, Siggs, O

The why and how of thymocyte negative selection. by Siggs, O, Makaroff, L, Liston, A

ZBTB1 is a determinant of lymphoid development. by Siggs, O, Li, X, Xia, Y, Beutler, B

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. by Siggs, O, Schnabl, B, Webb, B, Beutler, B

NOVEL LYMPHOCYTE DEFICIENCIES REVEALED BY MOUSE FORWARD GENETICS by Siggs, O, Bull, K, Beutler, B, Cornall, R

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. by Siggs, O, Yates, A, Schlenner, S, Liston, A, Lesage, S, Goodnow, C

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice by Siggs, O, Grieve, A, Xu, H, Bambrough, P, Christova, Y, Freeman, M

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. by Siggs, O, Cruite, J, Du, X, Rutschmann, S, Masliah, E, Beutler, B, Oldstone, M

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. by Siggs, O, Arnold, C, Huber, C, Pirie, E, Xia, Y, Lin, P, Nemazee, D, Beutler, B

iRhom2 is required for the secretion of mouse TNFα. by Siggs, O, Xiao, N, Wang, Y, Shi, H, Tomisato, W, Li, X, Xia, Y, Beutler, B

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. by Siggs, O, Miosge, L, Yates, A, Kucharska, E, Sheahan, D, Brdicka, T, Weiss, A, Liston, A, Goodnow, C

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. by Won, S, Eidenschenk, C, Arnold, C, Siggs, O, Sun, L, Brandl, K, Mullen, T, Nemerow, G, Moresco, E, Beutler, B

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. by Arnold, C, Pirie, E, Dosenovic, P, McInerney, G, Xia, Y, Wang, N, Li, X, Siggs, O, Karlsson Hedestam, G, Beutler, B

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. by Brandl, K, Sun, L, Neppl, C, Siggs, O, Le Gall, S, Tomisato, W, Li, X, Du, X, Maennel, D, Blobel, C, Beutler, B

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. by Mérino, D, Giam, M, Hughes, P, Siggs, O, Heger, K, O'Reilly, L, Adams, J, Strasser, A, Lee, E, Fairlie, W, Bouillet, P