Editorial: Next generation in vitro models to study chronic pulmonary diseases by Fama Thiam, Alen Faiz, Simon D. Pouwels, Simon D. Pouwels, Simon D. Pouwels, Emmanuel T. Osei, Emmanuel T. Osei

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The development, validation, and in vivo testing of a high-precision bronchial epithelial lining fluid sampling device by Akash Gupta, Akash Gupta, Akash Gupta, Janette K. Burgess, Janette K. Burgess, Janette K. Burgess, Dirk-Jan Slebos, Dirk-Jan Slebos, Simon D. Pouwels, Simon D. Pouwels, Simon D. Pouwels

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Airway granulation response to lung-implantable medical devices: a concise overview by Sharyn A. Roodenburg, Simon D. Pouwels, Dirk-Jan Slebos

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Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction by Mugdha M. Joglekar, Dirk-Jan Slebos, Jeroen Leijten, Janette K. Burgess, Simon D. Pouwels

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Low serum double-stranded DNA levels are associated with higher survival rates in severe COPD patients by Sharyn A. Roodenburg, Jorine E. Hartman, Ilse A. Eichhorn, Dirk-Jan Slebos, Simon D. Pouwels

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Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip by Brady Rae, Gwenda F. Vasse, Jalal Mosayebi, Maarten van den Berge, Simon D. Pouwels, Irene H. Heijink

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Comorbidities reduce survival and quality of life in COPD with severe lung hyperinflation by Else A.M.D. ter Haar, Dirk-Jan Slebos, Karin Klooster, Simon D. Pouwels, Jorine E. Hartman

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Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases by Mugdha M. Joglekar, Mugdha M. Joglekar, Mehmet Nizamoglu, Mehmet Nizamoglu, YiWen Fan, YiWen Fan, Sai Sneha Priya Nemani, Sai Sneha Priya Nemani, Markus Weckmann, Markus Weckmann, Simon D. Pouwels, Simon D. Pouwels, Simon D. Pouwels, Irene H. Heijink, Irene H. Heijink, Irene H. Heijink, Barbro N. Melgert, Barbro N. Melgert, Janesh Pillay, Janesh Pillay, Janette K. Burgess, Janette K. Burgess, Janette K. Burgess

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Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products by Alen Faiz, Senani N.H. Rathnayake, Nick H.T. ten Hacken, Victor Guryev, Maarten van den Berge, Simon D. Pouwels

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Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts by Kaj E. C. Blokland, Kaj E. C. Blokland, Kaj E. C. Blokland, Kaj E. C. Blokland, Mehmet Nizamoglu, Mehmet Nizamoglu, Habibie Habibie, Habibie Habibie, Habibie Habibie, Theo Borghuis, Theo Borghuis, Michael Schuliga, Barbro N. Melgert, Barbro N. Melgert, Barbro N. Melgert, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight, Corry-Anke Brandsma, Corry-Anke Brandsma, Simon D. Pouwels, Simon D. Pouwels, Simon D. Pouwels, Janette K. Burgess, Janette K. Burgess

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Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium by Simon D. Pouwels, Maarten van den Berge, Gwenda F. Vasse, Wim Timens, Corry-Anke Brandsma, Hananeh Aliee, Pieter S. Hiemstra, Victor Guryev, Alen Faiz

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Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular s... by Simon D. Pouwels, Alina Sigaeva, Shanna de Boer, Ilse A. Eichhorn, Lisanne Koll, Jeroen Kuipers, Romana Schirhagl, Irene H. Heijink, Janette K. Burgess, Dirk-Jan Slebos

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Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms by Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge

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Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM by Kaj E. C. Blokland, Habibie Habibie, Theo Borghuis, Greta J. Teitsma, Michael Schuliga, Barbro N. Melgert, Darryl A. Knight, Corry-Anke Brandsma, Simon D. Pouwels, Janette K. Burgess

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Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells by Dennis M. L. W. Kruk, Marissa Wisman, Jacobien A. Noordhoek, Mehmet Nizamoglu, Marnix R. Jonker, Harold G. de Bruin, Karla Arevalo Gomez, Nick H. T. ten Hacken, Simon D. Pouwels, Irene H. Heijink

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Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing by Kaj E. C. Blokland, David W. Waters, Michael Schuliga, Jane Read, Simon D. Pouwels, Christopher L. Grainge, Jade Jaffar, Glen Westall, Steven E. Mutsaers, Cecilia M. Prêle, Janette K. Burgess, Darryl A. Knight

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Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS by Pauline J.M. Kuks, Tessa M. Kole, Monica Kraft, Salman Siddiqui, Leonardo M. Fabbri, Klaus F. Rabe, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Jan Willem W.H. Kocks, Kian Fan Chung, Ian M. Adcock, Pankaj K. Bhavsar, Nazanin Zounemat Kermani, Irene H. Heijink, Simon D. Pouwels, Huib A.M. Kerstjens, Dirk-Jan Slebos, Maarten van den Berge

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Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD by Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler

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