New Synthetic Methodology for Drug-like Molecules by Graeme Barker, Simona Rapposelli

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Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders by Federica Saponaro, Simona Sestito, Massimiliano Runfola, Simona Rapposelli, Simona Rapposelli, Grazia Chiellini

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Editorial: New insights into the mechanisms of resistance to anti-cancer drugs by Francesco Bertoni, Francesco Bertoni, Simona Rapposelli

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Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases by Andrea Bacci, Massimiliano Runfola, Simona Sestito, Simona Rapposelli

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Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation by Stefano Alcaro, Maria Laura Bolognesi, Alfonso T. García-Sosa, Simona Rapposelli

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Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics by Massimiliano Runfola, Simona Sestito, Sheraz Gul, Grazia Chiellini, Simona Rapposelli

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Investigating Curcumin/Intestinal Epithelium Interaction in a Millifluidic Bioreactor by Joana Costa, Vanessa Almonti, Ludovica Cacopardo, Daniele Poli, Simona Rapposelli, Arti Ahluwalia

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Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges by Vito Antonio Baldassarro, Corinne Quadalti, Massimiliano Runfola, Clementina Manera, Simona Rapposelli, Laura Calzà

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Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs by Simona Sestito, Giulia Nesi, Rongbiao Pi, Rongbiao Pi, Rongbiao Pi, Marco Macchia, Simona Rapposelli

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Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation by Ilaria Casari, Alice Domenichini, Simona Sestito, Emily Capone, Gianluca Sala, Simona Rapposelli, Marco Falasca

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Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton by Simona Rapposelli, Serena Cuboni, Maria Digiacomo, Annalina Lapucci, Maria Letizia Trincavelli, Tiziano Tuccinardi, Aldo Balsamo

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Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis by Bokyung Kim, Young Ho Ko, Massimiliano Runfola, Simona Rapposelli, Gabriella Ortore, Grazia Chiellini, Jin Hae Kim

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TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD by Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Amedeo Columbano, Andrea Perra

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Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids by Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli

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Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis by Andrea Caddeo, Marina Serra, Francesca Sedda, Andrea Bacci, Clementina Manera, Simona Rapposelli, Amedeo Columbano, Andrea Perra, Marta Anna Kowalik

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Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6 by Lorenza Bellusci, Massimiliano Runfola, Vittoria Carnicelli, Simona Sestito, Federica Fulceri, Filippo Santucci, Paola Lenzi, Francesco Fornai, Simona Rapposelli, Nicola Origlia, Riccardo Zucchi, Grazia Chiellini

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New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection by Lorenza Bellusci, Annunziatina Laurino, Martina Sabatini, Simona Sestito, Paola Lenzi, Laura Raimondi, Simona Rapposelli, Francesca Biagioni, Francesco Fornai, Francesco Fornai, Alessandra Salvetti, Leonardo Rossi, Riccardo Zucchi, Grazia Chiellini

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Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands by Filippo Minutolo, Simone Bertini, Adriano Martinelli, Gabriella Ortore, Giorgio Placanica, Giovanni Prota, Simona Rapposelli, Tiziano Tuccinardi, Shubin Sheng, Kathryn E. Carlson, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Marco Macchia

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications by Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska, Bahare Salehi, Bahare Salehi, William N. Setzer, William N. Setzer, Noura S. Dosoky, Yasaman Taheri, Yasaman Taheri, Marc El Beyrouthy, Miquel Martorell, Miquel Martorell, Elise Adrian Ostrander, Hafiz Ansar Rasul Suleria, William C. Cho, Alfred Maroyi, Natália Martins, Natália Martins

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Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells by Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A. Mohamed, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Giuseppe Portella, Roger G. Pertwee, Robert B. Laprairie, Anna Maria Malfitano, Clementina Manera

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