A Case of Adult-Onset Still’s Disease Caused by a Novel Splicing Mutation in TNFAIP3 Successfully Treated With Tocilizumab by Dylan Lawless, Shelly Pathak, Thomas Edward Scambler, Lylia Ouboussad, Rashida Anwar, Sinisa Savic, Sinisa Savic

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Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness... by Stephanie R. Harrison, Thomas Scambler, Lylia Oubussad, Chi Wong, Miriam Wittmann, Miriam Wittmann, Miriam Wittmann, Michael F. McDermott, Sinisa Savic, Sinisa Savic, Sinisa Savic

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Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications by Anoop Mistry, Thomas Scambler, David Parry, Mark Wood, Gabriela Barcenas-Morales, Clive Carter, Rainer Doffinger, Sinisa Savic, Sinisa Savic

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Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap) by Leigh D Church, Sinisa Savic, Michael F McDermott

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Mixed results with baricitinib in biological-resistant adult-onset Still’s disease and undifferentiated systemic autoinflammatory disease by Maya H Buch, Sinisa Savic, Dennis G McGonagle, Mark Kacar, John Fitton, Andrew K Gough

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Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication by Abdulla Watad, Abdulla Watad, Mark Kacar, Mark Kacar, Nicola Luigi Bragazzi, Qiao Zhou, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, Catherine Cargo, Dennis McGonagle, Sinisa Savic, Sinisa Savic

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Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation by Samuel Lara-Reyna, Samuel Lara-Reyna, Samuel Lara-Reyna, Thomas Scambler, Thomas Scambler, Jonathan Holbrook, Jonathan Holbrook, Jonathan Holbrook, Chi Wong, Chi Wong, Chi Wong, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Fabio Martinon, Fabio Martinon, Sinisa Savic, Sinisa Savic, Sinisa Savic, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott

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Management of penicillin allergy in primary care: a qualitative study with patients and primary care physicians by Marta Wanat, Sibyl Anthierens, Christopher C. Butler, Louise Savic, Sinisa Savic, Sue H. Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine

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Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del. by Heledd H Jarosz-Griffiths, Lindsey Gillgrass, Laura R Caley, Giulia Spoletini, Ian J Clifton, Christine Etherington, Sinisa Savic, Michael F McDermott, Daniel Peckham

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Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del by Heledd H. Jarosz-Griffiths, Lindsey Gillgrass, Laura R. Caley, Giulia Spoletini, Ian J. Clifton, Christine Etherington, Sinisa Savic, Michael F. McDermott, Daniel Peckham

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ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis by Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott

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Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder by Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic

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Recovery of Bone Marrow Function in VEXAS Syndrome-potential Role for Romiplostim by Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James Poulter, David G. Kent, Sinisa Savic, on behalf of the ImmunAID consortium*

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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis by Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham

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Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience by Dorota M. Rowczenio, Sónia Melo Gomes, Juan I. Aróstegui, Anna Mensa-Vilaro, Ebun Omoyinmi, Hadija Trojer, Anna Baginska, Alberto Baroja-Mazo, Pablo Pelegrin, Sinisa Savic, Thirusha Lane, Rene Williams, Paul Brogan, Helen J. Lachmann, Philip N. Hawkins

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Managing Penicillin Allergy in Primary Care: An Important but Neglected Aspect of Antibiotic Stewardship by Marta Wanat, Sibyl Anthierens, Marta Santillo, Catherine Porter, Joanne Fielding, Mina Davoudianfar, Emily Bongard, Ly-Mee Yu, Christopher Butler, Louise Savic, Sinisa Savic, Johanna Cook, Kelsey Armitage, Philip Howard, Sue Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine

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Developing a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice and subsequently change antibiotic use by Sarah Tonkin-Crine, Robert West, Sinisa Savic, Jonathan Sandoe, Ly-Mee Yu, Sue Pavitt, Christopher C Butler, Marta Wanat, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Philip Howard, Catherine Porter, Mandy East, Marta Santillo, Louise Savic, Joanne Fielding, Jenny Boards

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Utilising primary care electronic health records to deliver the ALABAMA randomised controlled trial of penicillin allergy assessment by Shadia Ahmed, Joanne Fielding, Catherine E. Porter, Kelsey F. Armitage, Marta Wanat, Chris Bates, Lazarina Engonidou, Robert M. West, Ly-Mee Yu, Ushma Galal, Philip Howard, Christopher C. Butler, Sinisa Savic, Jenny Boards, Sarah Tonkin-Crine, John Parry, Sue A. Pavitt, Jonathan T. Sandoe, on behalf of ALABAMA research team

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Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice by Sarah Tonkin-Crine, Robert West, Sinisa Savic, Jonathan Sandoe, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Sue H Pavitt, Philip Howard, Catherine Porter, Mandy East, Marta Santillo, Louise Savic, Joanne Fielding, Jenny Boards, Catherine E Porter, Jonathan AT Sandoe

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Penicillin allergy status and its effect on antibiotic prescribing, patient outcomes and antimicrobial resistance (ALABAMA): protocol for a multicentre, parallel-arm, open-label, r... by Sarah Tonkin-Crine, Sinisa Savic, Robert M West, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Johanna Cook, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Philip Howard, Marta Santillo, Jenny Boards, Jonathan A T Sandoe, Ruben Mujica-Mota, Razan Saman, Kelsey Fiona Armitage, Catherine E Porter, Shadia Ahmed, Kate Corfield

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