PB1884: ENGAGING INNATE IMMUNITY: A PHASE 1 DOSE ESCALATION STUDY TO ASSESS SAFETY AND TOLERABILITY OF AFM28 MONOTHERAPY IN PATIENTS WITH RELAPSED/REFRACTORY CD123-POSITIVE ACUTE M... by Montserrat Arnan, Pau Montesinos, Stéphane de Botton, Christian Recher, Lydia Wunderle, Michael Emig, Andreas Harstrick, Kerstin Pietzko, Sheena Pinto, Paulien Ravenstijn, Naval Daver

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CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia by Awatef Allouch, Laurent Voisin, Yanyan Zhang, Syed Qasim Raza, Yann Lecluse, Julien Calvo, Dorothée Selimoglu-Buet, Stéphane de Botton, Fawzia Louache, Françoise Pflumio, Eric Solary, Jean-Luc Perfettini

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P490: UPDATED SURVIVAL, BLOOD COUNT RECOVERY AND SAFETY RESULTS FROM THE AGILE STUDY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED WITH IVOSIDENIB + AZACITIDINE COMPARED TO PLACE... by Hartmut Döhner, Pau Montesinos, Susana Vives Polo, Ewa Zarzycka, Jianxiang Wang, Marta Riva, Michael Heuser, Rodrigo Calado, Andre Schuh, Su-Peng Yeh, Jianan Hui, Diego Gianolio, Prapti A Patel, Christian Recher, Stephane de Botton

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Impact of additional genetic alterations on the outcome of patients with NPM1-mutated cytogenetically normal acute myeloid leukemia by Pierre Peterlin, Aline Renneville, Raouf Ben Abdelali, Olivier Nibourel, Xavier Thomas, Cécile Pautas, Stéphane de Botton, Emmanuel Raffoux, Jean-Michel Cayuela, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Sylvie Castaigne, Claude Preudhomme, Claude Gardin, Hervé Dombret

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Venetoclax–proteasome inhibitor–dexamethasone for unfit patients with blastic plasmacytoid dendritic cell neoplasm by Sabine Khalife-Hachem, Arnaud Pages, Elie Akoury, Sarah Bonnet, Rudy Birsen, Clémence Busquet, Adrien Contejean, Alina Danu, Stéphane de Botton, Marie de Charette, Pierre Yves Dumas, Arnaud Jaccard, Anne Marfaing-Koka, Christophe Willekens, Eric Deconinck, David Ghez

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Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML by Nicolas Duployez, Jean-Edouard Martin, Sabine Khalife-Hachem, Ryane Benkhelil, Véronique Saada, Christophe Marzac, Nathalie Auger, Alice Marceau-Renaut, Rémi Favier, Paola Ballerini, Olivier Caron, André Baruchel, Stéphane de Botton, Claude Preudhomme, Jean-Baptiste Micol, Hana Raslova, Iléana Antony-Debré

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TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia by Olivier Kosmider, Véronique Gelsi-Boyer, Marion Ciudad, Cindy Racoeur, Valérie Jooste, Norbert Vey, Bruno Quesnel, Pierre Fenaux, Jean-Noël Bastie, Odile Beyne-Rauzy, Aspasia Stamatoulas, François Dreyfus, Norbert Ifrah, Stéphane de Botton, William Vainchenker, Oliver A. Bernard, Daniel Birnbaum, Michaëla Fontenay, Eric Solary

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Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group by Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux

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PB1773: AML AND MDS WITH RARA OVEREXPRESSION: MOLECULAR AND CLINICAL FEATURES OF PATIENTS ENROLLED IN A PHASE 2 TRIAL EVALUATING TAMIBAROTENE-BASED THERAPY by Stéphane de Botton, Thomas Cluzeau, Carlos Vigil, Rachel Cook, Philippe Rousselot, David Rizzieri, Jane Liesveld, Pierre Fenaux, Thorsten Braun, Arnaud Pigneux, Pierre Peterlin, Sofia Paul, Nisha Rajagopal, John Carulli, David Roth, Angela Volkert, Tanya Abdul Malak, Michael Kelly, Virginia Klimek, Eytan Stein

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Minimal residual disease monitoring in acute myeloid leukemia with non-A/B/D-NPM1 mutations by digital polymerase chain reaction: feasibility and clinical use by Auriane Lesieur, Xavier Thomas, Olivier Nibourel, Nicolas Boissel, Laurène Fenwarth, Stéphane De Botton, Elise Fournier, Karine Celli-Lebras, Emmanuel Raffoux, Christian Recher, Juliette Lambert, Céline Berthon, Arnaud Pigneux, Raphael Itzykson, Pascal Turlure, Cécile Pautas, Jacques Vargaftig, Claude Preudhomme, Hervé Dombret, Nicolas Duployez

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P724: UPDATED SUBSTUDY RESULTS FOR IVOSIDENIB IN IDH1-MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME by Courtney Dinardo, Gail Roboz, Justin M. Watts, Yazan Madanat, Gabrielle T Prince, Praneeth Baratam, Stéphane de Botton, Anthony Stein, James M Foran, Martha L Arellano, David Sallman, Dylan M Marchione, Xiaofei Bai, Prapti A Patel, Stephanie M Kapsalis, Guillermo Garcia-Manero, Amir Fathi

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When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes by Christophe Willekens, Claude Chahine, Matteo Dragani, Sabine Khalife‐Hachem, Camille Bigenwald, Julien Rossignol, Cristina Castilla‐Llorente, Alina Danu, Jean‐Marie Michot, Veronique Saada, Sophie Cotteret, Christophe Marzac, Aline Renneville, Isabelle Plo, Sophie Broutin, Nelly Bosselut, Bruno Cassinat, Julien Lazarovici, Nathalie Droin, Stephane De Botton

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P494: A FIRST-IN-HUMAN STUDY OF CD123 NK CELL ENGAGER SAR443579 IN RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA, B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA OR HIGH RISK-MYELODYSPLASIA by Anthony Selwyn Stein, Mojca Jongen-Lavrencic, Sylvain Garciaz, Gerwin A Huls, Abhishek Maiti, Nicolas Boissel, Stephane De Botton, Shaun Fleming, C. Michel Zwaan, David C. de Leeuw, Pinkal Desai, Martha Lucia Arellano, David Avigan, Saskia Langemeijer, Kyle Jensen, Timothy Wagenaar, Gu MI, Giovanni Abbadessa, Ashish Bajel

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Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers by Sabine Khalife-Hachem, Khalil Saleh, Florence Pasquier, Christophe Willekens, Anthony Tarabay, Leony Antoun, Thomas Grinda, Cristina Castilla-Llorente, Matthieu Duchmann, Cyril Quivoron, Nathalie Auger, Veronique Saada, Suzette Delaloge, Alexandra Leary, Aline Renneville, Ileana Antony-Debre, Filippo Rosselli, Stéphane De Botton, Flore Salviat, Christophe Marzac, Jean-Baptiste Micol

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Anti-ALK autoantibodies in patients with ALK-positive Non-Small Cell Lung Cancer (NSCLC): A monocentric experience by Claudia Parisi, José Carlos Benitez, Hélène Lecourt, Filippo Gustavo dall’Olio, Mihaela Aldea, Felix Blanc-Durand, Véronique Vergé, Cyril Quivoron, Charles Naltet, Pamela Abdayem, Pernelle Lavaud, Maria Rosa Ghigna, Luc Friboulet, Yohann Loriot, Stéphane De Botton, Vincent Ribrag, Andrea Ardizzoni, David Planchard, Jean-Charles Soria, Fabrice Barlesi, Benjamin Besse

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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

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P504: UPDATED DATA FOR ZIFTOMENIB IN PATIENTS WITH NPM1-MUTATED RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA by Amir Fathi, Eunice Wang, Ghayas Issa, Jessica Altman, Pau Montesinos, Stéphane de Botton, Roland Walter, Kirsten Pettit, Mrinal Patnaik, Marina Kremyanskaya, Maria Baer, James M Foran, Gary Schiller, Lionel Ades, Maël Heiblig, Pierre Peterlin, Olga Salamero Garcia, Cristina Papayannidis, Kun Nie, Julie Ahsan Mackey, Marilyn Tabachri, Daniel Corum, Mollie Leoni, Stephen Dale, Harry Erba

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Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: results from an international collaborative study by Sabine Kayser, Robert K. Hills, Marlise R. Luskin, Andrew M. Brunner, Christine Terré, Jörg Westermann, Kamal Menghrajani, Carole Shaw, Maria R. Baer, Michelle A. Elliott, Alexander E. Perl, Zdeněk Ráčil, Jiri Mayer, Pavel Zak, Tomas Szotkowski, Stéphane de Botton, David Grimwade, Karin Mayer, Roland B. Walter, Alwin Krämer, Alan K. Burnett, Anthony D. Ho, Uwe Platzbecker, Christian Thiede, Gerhard Ehninger, Richard M. Stone, Christoph Röllig, Martin S. Tallman, Elihu H. Estey, Carsten Müller-Tidow, Nigel H. Russell, Richard F. Schlenk, Mark J. Levis

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