Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation. by Thomas Frogne, Kathrine Beck Sylvestersen, Stefan Kubicek, Michael Lund Nielsen, Jacob Hecksher-Sørensen

Get full text

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets by Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek

Get full text

Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity. by Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Stuart L. Schreiber, Bridget K. Wagner

Get full text

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. by Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Stuart L Schreiber, Bridget K Wagner

Get full text

High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells by Ruochen Jia, Leon Kutzner, Anna Koren, Kathrin Runggatscher, Peter Májek, André C. Müller, Michael Schuster, Christoph Bock, Joanna I. Loizou, Stefan Kubicek, Robert Kralovics

Get full text

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. by Amit Choudhary, Kaihui Hu He, Philipp Mertins, Namrata D Udeshi, Vlado Dančík, Dina Fomina-Yadlin, Stefan Kubicek, Paul A Clemons, Stuart L Schreiber, Steven A Carr, Bridget K Wagner

Get full text

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists by Sri Teja Mullapudi, Christian SM Helker, Giulia LM Boezio, Hans-Martin Maischein, Anna M Sokol, Stefan Guenther, Hiroki Matsuda, Stefan Kubicek, Johannes Graumann, Yu Hsuan Carol Yang, Didier YR Stainier

Get full text

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity by Andras Boeszoermenyi, Léa Bernaleau, Xudong Chen, Felix Kartnig, Min Xie, Haobo Zhang, Sensen Zhang, Maeva Delacrétaz, Anna Koren, Ann-Katrin Hopp, Vojtech Dvorak, Stefan Kubicek, Daniel Aletaha, Maojun Yang, Manuele Rebsamen, Leonhard X. Heinz, Giulio Superti-Furga

Get full text

Pharmacological perturbation of the phase-separating protein SMNDC1 by Lennart Enders, Marton Siklos, Jan Borggräfe, Stefan Gaussmann, Anna Koren, Monika Malik, Tatjana Tomek, Michael Schuster, Jiří Reiniš, Elisa Hahn, Andrea Rukavina, Andreas Reicher, Tamara Casteels, Christoph Bock, Georg E. Winter, J. Thomas Hannich, Michael Sattler, Stefan Kubicek

Get full text

Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus by Tayma Handal, Sarah Juster, Manar Abu Diab, Shira Yanovsky-Dagan, Fouad Zahdeh, Uria Aviel, Roni Sarel-Gallily, Shir Michael, Ester Bnaya, Shulamit Sebban, Yosef Buganim, Yotam Drier, Vincent Mouly, Stefan Kubicek, Walther J. A. A. van den Broek, Derick G. Wansink, Silvina Epsztejn-Litman, Rachel Eiges

Get full text

Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions by Peter Valent, Alberto Orfao, Stefan Kubicek, Philipp Staber, Torsten Haferlach, Michael Deininger, Karoline Kollmann, Thomas Lion, Irene Virgolini, Georg Winter, Oliver Hantschel, Lukas Kenner, Johannes Zuber, Florian Grebien, Richard Moriggl, Gregor Hoermann, Olivier Hermine, Michael Andreeff, Christoph Bock, Tariq Mughal, Stefan N. Constantinescu, Robert Kralovics, Veronika Sexl, Radek Skoda, Giulio Superti-Furga, Ulrich Jäger

Get full text

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia by Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl

Get full text

A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. by Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seiser

Get full text