Editorial: Diagnostic, prognostic and treatment efficacy power of biomarkers of aging for frailty, age-related diseases and multimorbidity by Stefano Salvioli, Stefano Salvioli, Florencia M. Barbé-Tuana, Maria Conte

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Different roles of circulating and intramuscular GDF15 as markers of skeletal muscle health by Antonio Chiariello, Giuseppe Conte, Luca Rossetti, Luca Rossetti, Lorenzo Trofarello, Stefano Salvioli, Stefano Salvioli, Maria Conte

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The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age by Maria Conte, Maria Conte, Morena Martucci, Marco Sandri, Marco Sandri, Claudio Franceschi, Claudio Franceschi, Stefano Salvioli, Stefano Salvioli

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Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity by Claudio Franceschi, Stefano Salvioli, Stefano Salvioli, Paolo Garagnani, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri, Miriam Capri

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Italian physiotherapists’ knowledge of and adherence to osteoarthritis clinical practice guidelines: a cross-sectional study by Simone Battista, Stefano Salvioli, Serena Millotti, Marco Testa, Andrea Dell’Isola

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The interpretation of clinical relevance in randomised clinical trials in patients with chronic low back pain: protocol for a meta-research study by Tiziano Innocenti, Tim Schleimer, Stefano Salvioli, Silvia Giagio, Raymond Ostelo, Alessandro Chiarotto

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Charting the NF-κB pathway interactome map. by Paolo Tieri, Alberto Termanini, Elena Bellavista, Stefano Salvioli, Miriam Capri, Claudio Franceschi

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αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. by Tatiana Gianni, Stefano Salvioli, Liudmila S Chesnokova, Lindsey M Hutt-Fletcher, Gabriella Campadelli-Fiume

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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates by Claudio Franceschi, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Miriam Capri, Stefano Salvioli, Stefano Salvioli

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Muscle‐specific Perilipin2 down‐regulation affects lipid metabolism and induces myofiber hypertrophy by Maria Conte, Andrea Armani, Giuseppe Conte, Andrea Serra, Claudio Franceschi, Marcello Mele, Marco Sandri, Stefano Salvioli

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The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease by Antonio Chiariello, Sabrina Valente, Gianandrea Pasquinelli, Alessandra Baracca, Gianluca Sgarbi, Giancarlo Solaini, Valentina Medici, Valentina Fantini, Tino Emanuele Poloni, Monica Tognocchi, Marina Arcaro, Daniela Galimberti, Claudio Franceschi, Miriam Capri, Miriam Capri, Stefano Salvioli, Stefano Salvioli, Maria Conte, Maria Conte

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GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness by Maria Conte, Morena Martucci, Giovanni Mosconi, Antonio Chiariello, Maria Cappuccilli, Valentina Totti, Aurelia Santoro, Claudio Franceschi, Stefano Salvioli

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Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile by Monica Tognocchi, Maria Conte, Lara Testai, Morena Martucci, Andrea Serra, Stefano Salvioli, Vincenzo Calderone, Marcello Mele, Giuseppe Conte

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Identification of a T cell gene expression clock obtained by exploiting a MZ twin design by Daniel Remondini, Nathan Intrator, Claudia Sala, Michela Pierini, Paolo Garagnani, Isabella Zironi, Claudio Franceschi, Stefano Salvioli, Gastone Castellani

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Histochemical Characterisation and Gene Expression Analysis of Skeletal Muscles from Maremmana and Aubrac Steers Reared on Grazing and Feedlot Systems by Giulia Foggi, Francesca Ciucci, Maria Conte, Laura Casarosa, Andrea Serra, Elisabetta Giannessi, Carla Lenzi, Stefano Salvioli, Giuseppe Conte, Marcello Mele

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B Cells Isolated from Individuals Who Do Not Respond to the HBV Vaccine Are Characterized by Higher DNA Methylation-Estimated Aging Compared to Responders by Katarzyna Malgorzata Kwiatkowska, Simona Anticoli, Stefano Salvioli, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Anna Ruggieri, Paolo Garagnani

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Gut microbiome in Down syndrome. by Elena Biagi, Marco Candela, Manuela Centanni, Clarissa Consolandi, Simone Rampelli, Silvia Turroni, Marco Severgnini, Clelia Peano, Alessandro Ghezzo, Maria Scurti, Stefano Salvioli, Claudio Franceschi, Patrizia Brigidi

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Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. by Sebastiano Collino, Ivan Montoliu, François-Pierre J Martin, Max Scherer, Daniela Mari, Stefano Salvioli, Laura Bucci, Rita Ostan, Daniela Monti, Elena Biagi, Patrizia Brigidi, Claudio Franceschi, Serge Rezzi

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Correction: Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism. by Sebastiano Collino, Ivan Montoliu, François-Pierre J. Martin, Max Scherer, Daniela Mari, Stefano Salvioli, Laura Bucci, Rita Ostan, Daniela Monti, Elena Biagi, Patrizia Brigidi, Claudio Franceschi, Serge Rezzi

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A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features by Aurelia Santoro, Aurelia Santoro, Alberto Bazzocchi, Giulia Guidarelli, Rita Ostan, Rita Ostan, Enrico Giampieri, Daniele Mercatelli, Maria Scurti, Maria Scurti, Agnes Berendsen, Olga Surala, Amy Jennings, Nathalie Meunier, Elodie Caumon, Rachel Gillings, Fawzi Kadi, Frederic Capel, Kevin D. Cashman, Barbara Pietruszka, Edith J. M. Feskens, Lisette C. P. G. M. De Groot, Giuseppe Battista, Stefano Salvioli, Stefano Salvioli, Claudio Franceschi, Claudio Franceschi

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