Editorial: Tailoring immunotherapy in gastrointestinal cancer: the role of circulating factors by Stefano Ugel, Chiara Bazzichetto, Fabiana Conciatori

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Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies by Simone Caligola, Francesco De Sanctis, Stefania Canè, Stefano Ugel

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The Engagement Between MDSCs and Metastases: Partners in Crime by Rosalinda Trovato, Stefania Canè, Varvara Petrova, Silvia Sartoris, Stefano Ugel, Francesco De Sanctis

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Moonlighting Proteins Are Important Players in Cancer Immunology by Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano Ugel

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A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment by Francesca Hofer, Gianna Di Sario, Chiara Musiu, Silvia Sartoris, Francesco De Sanctis, Stefano Ugel

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The Endless Saga of Monocyte Diversity by Stefania Canè, Stefano Ugel, Rosalinda Trovato, Ilaria Marigo, Francesco De Sanctis, Silvia Sartoris, Vincenzo Bronte

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"Open Sesame" to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer by Tian Wang, Yushu Hu, Silvia Dusi, Fang Qi, Silvia Sartoris, Stefano Ugel, Francesco De Sanctis

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Dynamics of SARS-CoV2 Infection and Multi-Drug Resistant Bacteria Superinfection in Patients With Assisted Mechanical Ventilation by Annarita Mazzariol, Anna Benini, Ilaria Unali, Riccardo Nocini, Marcello Smania, Anna Bertoncelli, Francesco De Sanctis, Stefano Ugel, Katia Donadello, Enrico Polati, Davide Gibellini

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Pre-diagnostic prognostic value of leukocytes count and neutrophil-to-lymphocyte ratio in patients who develop colorectal cancer by Giulia Turri, Simone Caligola, Stefano Ugel, Cristian Conti, Silvia Zenuni, Valeria Barresi, Andrea Ruzzenente, Giuseppe Lippi, Aldo Scarpa, Vincenzo Bronte, Alfredo Guglielmi, Corrado Pedrazzani

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Circulating IgG4+ Plasmablast Count as a Diagnostic Tool in Autoimmune Pancreatitis by Rachele Ciccocioppo, Giulia De Marchi, Valeria Zuliani, Annalisa Adamo, Antonio Amodio, Pietro Campagnola, Enrico Maria Gabrieletto, Nicolò de Pretis, Stefano Ugel, Pietro Delfino, Mauro Krampera, Luca Frulloni

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Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic... by Paola Cappello, Maurizio Martini, Aldo Scarpa, Stefano Ugel, Francesco De Sanctis, Giampaolo Tortora, Emilio Bria, Vincenzo Corbo, Carmine Carbone, Geny Piro, Antonio Agostini, Pietro Delfino, Vincenzo Nasca, Francesco Spallotta, Claudio Sette

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B-cell receptor signaling activity identifies patients with mantle cell lymphoma at higher risk of progression by Simona Gambino, Francesca Maria Quaglia, Marilisa Galasso, Chiara Cavallini, Roberto Chignola, Ornella Lovato, Luca Giacobazzi, Simone Caligola, Annalisa Adamo, Santosh Putta, Antonino Aparo, Isacco Ferrarini, Stefano Ugel, Rosalba Giugno, Massimo Donadelli, Ilaria Dando, Mauro Krampera, Carlo Visco, Maria Teresa Scupoli

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The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumonia by Rachele Ciccocioppo, Davide Gibellini, Giuseppe Astori, Martina Bernardi, Angela Bozza, Katia Chieregato, Francesca Elice, Stefano Ugel, Simone Caligola, Francesco De Sanctis, Stefania Canè, Alessandra Fiore, Rosalinda Trovato, Antonio Vella, Varvara Petrova, Giuseppe Amodeo, Monica Santimaria, Annarita Mazzariol, Luca Frulloni, Marco Ruggeri, Enrico Polati, Vincenzo Bronte

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Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis by Sara Costa, Dalila Bevilacqua, Elena Caveggion, Sara Gasperini, Elena Zenaro, Francesca Pettinella, Marta Donini, Stefano Dusi, Gabriela Constantin, Silvia Lonardi, William Vermi, Francesco De Sanctis, Stefano Ugel, Tiziana Cestari, Clare L. Abram, Clifford A. Lowell, Pamela Rodegher, Franco Tagliaro, Giampiero Girolomoni, Marco A. Cassatella, Patrizia Scapini

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Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3 by Rosalinda Trovato, Alessandra Fiore, Sara Sartori, Stefania Canè, Rosalba Giugno, Luciano Cascione, Salvatore Paiella, Roberto Salvia, Francesco De Sanctis, Ornella Poffe, Cristina Anselmi, Francesca Hofer, Silvia Sartoris, Geny Piro, Carmine Carbone, Vincenzo Corbo, Rita Lawlor, Samantha Solito, Laura Pinton, Susanna Mandruzzato, Claudio Bassi, Aldo Scarpa, Vincenzo Bronte, Stefano Ugel

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Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer by Antonio Agostini, Ilaria Guerriero, Geny Piro, Giuseppe Quero, Luca Roberto, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Giulia Scaglione, Francesco De Sanctis, Antonella Sistigu, Martina Musella, Alberto Larghi, Gianenrico Rizzatti, Donatella Lucchetti, Sergio Alfieri, Alessandro Sgambato, Emilio Bria, Laura Bizzozero, Sabrina Arena, Stefano Ugel, Vincenzo Corbo, Giampaolo Tortora, Carmine Carbone

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Deciphering the state of immune silence in fatal COVID-19 patients by Pierre Bost, Francesco De Sanctis, Stefania Canè, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit, Vincenzo Bronte

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Plasmacytoid Dendritic Cell, Slan⁺-Monocyte and Natural Killer Cell Counts Function as Blood Cell-Based Biomarkers for Predicting Responses to Immune Checkpoint Inhibito... by Francesca Pettinella, Chiara Lattanzi, Marta Donini, Elena Caveggion, Olivia Marini, Giulia Iannoto, Sara Costa, Elena Zenaro, Tiago Moderno Fortunato, Sara Gasperini, Matteo Giani, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Ilaria Mariangela Scaglione, Michele Milella, Annalisa Adamo, Ornella Poffe, Vincenzo Bronte, Stefano Dusi, Marco A. Cassatella, Stefano Ugel, Sara Pilotto, Patrizia Scapini

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Induction of immunosuppressive functions and NF-κB by FLIP in monocytes by Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray, Vincenzo Bronte

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Immune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell... by Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte, Stefano Ugel

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