Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal door Pietras, E, Mirantes-Barbeito, C, Fong, S, Loeffler, D, Kovtonyuk, L, Zhang, S, Lakshminarasimhan, R, Chin, C, Techner, J, Will, B, Nerlov, C, Steidl, U, Manz, M, Schroeder, T, Passegué, E

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. door Barreyro, L, Will, B, Bartholdy, B, Zhou, L, Todorova, T, Stanley, R, Ben-Neriah, S, Montagna, C, Parekh, S, Pellagatti, A, Boultwood, J, Paietta, E, Ketterling, R, Cripe, L, Fernandez, H, Greenberg, P, Tallman, MS, Steidl, C, Mitsiades, C, Verma, A, Steidl, U

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies door Smith, MA, Choudhary, GS, Pellagatti, A, Choi, K, Bolanos, LC, Bhagat, TD, Gordon-Mitchell, S, Von Ahrens, D, Pradhan, K, Steeples, V, Kim, S, Steidl, U, Walter, M, Fraser, IDC, Kulkarni, A, Salomonis, N, Komurov, K, Boultwood, J, Verma, A, Starczynowski, DT

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism door Ueda, K, Kumari, R, Schwenger, E, Wheat, JC, Bohorquez, O, Narayanagari, S-R, Taylor, SJ, Carvajal, LA, Pradhan, K, Bartholdy, B, Todorova, TI, Goto, H, Sun, D, Chen, J, Shan, J, Song, Y, Montagna, C, Xiong, S, Lozano, G, Pellagatti, A, Boultwood, J, Verma, A, Steidl, U

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. door Zhou, L, Opalinska, J, Sohal, D, Yu, Y, Mo, Y, Bhagat, T, Abdel-Wahab, O, Fazzari, M, Figueroa, M, Alencar, C, Zhang, J, Kambhampati, S, Parmar, S, Nischal, S, Hueck, C, Suzuki, M, Freidman, E, Pellagatti, A, Boultwood, J, Steidl, U, Sauthararajah, Y, Yajnik, V, McMahon, C, Gore, S, Platanias, L

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. door Will, B, Zhou, L, Vogler, T, Ben-Neriah, S, Schinke, C, Tamari, R, Yu, Y, Bhagat, T, Bhattacharyya, S, Barreyro, L, Heuck, C, Mo, Y, Parekh, S, McMahon, C, Pellagatti, A, Boultwood, J, Montagna, C, Silverman, L, Maciejewski, J, Greally, J, Ye, B, List, A, Steidl, C, Steidl, U, Verma, A

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling. door Bhagat, T, Zhou, L, Sokol, L, Kessel, R, Caceres, G, Gundabolu, K, Tamari, R, Gordon, S, Mantzaris, I, Jodlowski, T, Yu, Y, Jing, X, Polineni, R, Bhatia, K, Pellagatti, A, Boultwood, J, Kambhampati, S, Steidl, U, Stein, C, Ju, W, Liu, G, Kenny, P, List, A, Bitzer, M, Verma, A

miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling door Bhagat, T, Zhou, L, Sokol, L, Kessel, R, Caceres, G, Gundabolu, K, Tamari, R, Gordon, S, Mantzaris, I, Jodlowski, T, Yu, Y, Jing, X, Polineni, R, Bhatia, K, Pellagatti, A, Boultwood, J, Kambhampati, S, Steidl, U, Stein, C, Ju, W, Liu, G, Kenny, P, List, A, Bitzer, M, Verma, A

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. door Zhou, L, McMahon, C, Bhagat, T, Alencar, C, Yu, Y, Fazzari, M, Sohal, D, Heuck, C, Gundabolu, K, Ng, C, Mo, Y, Shen, W, Wickrema, A, Kong, G, Friedman, E, Sokol, L, Mantzaris, I, Mantzaris, G, Pellagatti, A, Boultwood, J, Platanias, L, Steidl, U, Yan, L, Yingling, J, Lahn, M

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine door Rahmani, NE, Ramachandra, N, Sahu, S, Gitego, N, Lopez, A, Pradhan, K, Bhagat, TD, Gordon-Mitchell, S, Pena, BR, Kazemi, M, Rao, K, Giricz, O, Maqbool, SB, Olea, R, Zhao, Y, Zhang, J, Dolatshad, H, Tittrea, V, Tatwavedi, D, Singh, S, Lee, J, Sun, T, Steidl, U, Shastri, A, Inoue, D, Abdel-Wahab, O, Pellagatti, A, Gavathiotis, E, Boultwood, J, Verma, A

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells door Shastri, A, Choudhary, G, Teixeira, M, Gordon-Mitchell, S, Ramachandra, N, Bernard, L, Bhattacharyya, S, Lopez, R, Pradhan, K, Giricz, O, Ravipati, G, Wong, L, Cole, S, Bhagat, T, Feld, J, Dhar, Y, Bartenstein, M, Thiruthuvanathan, V, Wickrema, A, Ye, B, Frank, D, Pellagatti, A, Boultwood, J, Zhou, T, Kim, Y, Macleod, A, Epling-Burnette, P, Ye, M, McCoon, P, Woessner, R, Steidl, U, Will, B, Verma, A

Wnt/ß-catenin activation by epigenetically aberrant stroma drives myelodysplastic syndrome door Bhagat, T, Chen, S, Bartenstein, M, Barlowe, TS, von Ahrens, D, Choudhary, GS, Tivnan, P, Amin, E, Marcondes, AM, Sanders, MA, Hoogenboezem, RM, Kambhampati, S, Ramachandra, N, Mantzaris, I, Sukrithan, V, Laurence, R, Lopez, R, Bhagat, P, Giricz, O, Sohal, D, Wickrema, A, Yeung, CC, Gritsman, K, Aplan, PD, Hochedlinger, K, Yu, Y, Pradhan, K, Zhang, J, Greally, J, Mukherjee, S, Pellagatti, A, Boultwood, J, Will, B, Steidl, U, Raaijmakers, MH, Deeg, HJ, Kharas, MG, Verma, A