Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors af Stephane Angers

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Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. af Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano

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The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma af Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux

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Identification of Novel Smoothened Ligands Using Structure-Based Docking. af Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers

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Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. af Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette

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A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response af Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge

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The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity. af Brenden Hurley, Donghyuk Lee, Adam Mott, Michael Wilton, Jun Liu, Yulu C Liu, Stephane Angers, Gitta Coaker, David S Guttman, Darrell Desveaux

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mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation af Hideyuki Komori, Geeta Rastogi, John Paul Bugay, Hua Luo, Sichun Lin, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz, Cheng-Yu Lee

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TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells af Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith

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Identifying chemogenetic interactions from CRISPR screens with drugZ af Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart

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The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity. af Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei

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A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE af Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon

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The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance af Nursen Balekoglu, Jean-Francois Michaud, Rachelle Sauvé, Kehinde S. Ayinde, Sichun Lin, Yijun Liu, Daniel A. Kramer, Kaiyue Zhang, Anika Steffen, Theresia Stradal, Stephane Angers, Baoyu Chen, Patricia T. Yam, Frédéric Charron

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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice af Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu

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CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma af Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux

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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy af Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers

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ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis af Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton

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A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. af Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux

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The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs af John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz

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Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer af Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux

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