Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors -н Stephane Angers

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Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. -н Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano

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The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma -н Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux

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Identification of Novel Smoothened Ligands Using Structure-Based Docking. -н Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers

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Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. -н Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette

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A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response -н Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge

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The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity. -н Brenden Hurley, Donghyuk Lee, Adam Mott, Michael Wilton, Jun Liu, Yulu C Liu, Stephane Angers, Gitta Coaker, David S Guttman, Darrell Desveaux

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mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation -н Hideyuki Komori, Geeta Rastogi, John Paul Bugay, Hua Luo, Sichun Lin, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz, Cheng-Yu Lee

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TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells -н Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith

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Identifying chemogenetic interactions from CRISPR screens with drugZ -н Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart

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A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE -н Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon

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The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance -н Nursen Balekoglu, Jean-Francois Michaud, Rachelle Sauvé, Kehinde S. Ayinde, Sichun Lin, Yijun Liu, Daniel A. Kramer, Kaiyue Zhang, Anika Steffen, Theresia Stradal, Stephane Angers, Baoyu Chen, Patricia T. Yam, Frédéric Charron

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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice -н Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu

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CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma -н Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux

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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy -н Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers

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ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis -н Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton

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Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs -н Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

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Systematic protein–protein interaction mapping for clinically relevant human GPCRs -н Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

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Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival -н Paul Guilhamon, Charles Chesnelong, Michelle M Kushida, Ana Nikolic, Divya Singhal, Graham MacLeod, Seyed Ali Madani Tonekaboni, Florence MG Cavalli, Christopher Arlidge, Nishani Rajakulendran, Naghmeh Rastegar, Xiaoguang Hao, Rozina Hassam, Laura J Smith, Heather Whetstone, Fiona J Coutinho, Bettina Nadorp, Katrina I Ellestad, H Artee Luchman, Jennifer Ai-wen Chan, Molly S Shoichet, Michael D Taylor, Benjamin Haibe-Kains, Samuel Weiss, Stephane Angers, Marco Gallo, Peter B Dirks, Mathieu Lupien

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