Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors 由 Stephane Angers

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Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. 由 Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano

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The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma 由 Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux

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Identification of Novel Smoothened Ligands Using Structure-Based Docking. 由 Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers

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Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. 由 Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette

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A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response 由 Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge

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The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity. 由 Brenden Hurley, Donghyuk Lee, Adam Mott, Michael Wilton, Jun Liu, Yulu C Liu, Stephane Angers, Gitta Coaker, David S Guttman, Darrell Desveaux

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mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation 由 Hideyuki Komori, Geeta Rastogi, John Paul Bugay, Hua Luo, Sichun Lin, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz, Cheng-Yu Lee

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TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells 由 Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith

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Identifying chemogenetic interactions from CRISPR screens with drugZ 由 Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart

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The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity. 由 Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei

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A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE 由 Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon

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The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance 由 Nursen Balekoglu, Jean-Francois Michaud, Rachelle Sauvé, Kehinde S. Ayinde, Sichun Lin, Yijun Liu, Daniel A. Kramer, Kaiyue Zhang, Anika Steffen, Theresia Stradal, Stephane Angers, Baoyu Chen, Patricia T. Yam, Frédéric Charron

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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice 由 Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu

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CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma 由 Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux

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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy 由 Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers

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ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis 由 Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton

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A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. 由 Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux

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The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs 由 John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz

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Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer 由 Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux

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