ETV6-ABL1-positive “chronic myeloid leukemia”: clinical and molecular response to tyrosine kinase inhibition Autor Fabiana Perna, Omar Abdel-Wahab, Ross L. Levine, Suresh C. Jhanwar, Kazunori Imada, Stephen D. Nimer

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Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia Autor Alan H. Shih, Stephen S. Chung, Emily K. Dolezal, Su-Jiang Zhang, Omar I. Abdel-Wahab, Christopher Y. Park, Stephen D. Nimer, Ross L. Levine, Virginia M. Klimek

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PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes Autor Pierre-Jacques Hamard, Gabriel E. Santiago, Fan Liu, Daniel L. Karl, Concepcion Martinez, Na Man, Adnan K. Mookhtiar, Stephanie Duffort, Sarah Greenblatt, Ramiro E. Verdun, Stephen D. Nimer

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The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells Autor Fabiana Perna, Ly P. Vu, Maria Themeli, Sonja Kriks, Ruben Hoya-Arias, Raya Khanin, Todd Hricik, Jorge Mansilla-Soto, Eirini P. Papapetrou, Ross L. Levine, Lorenz Studer, Michel Sadelain, Stephen D. Nimer

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Improving patient understanding and outcomes in myelodysplastic syndromes - An animated patient guide to MDS with visual formats of learning Autor David A. Sallman, Rafael Bejar, Guillermo Montalban-Bravo, Sandra E. Kurtin, Alan F. List, Guillermo Garcia-Manero, Stephen D. Nimer, Casey L. O'Connell, Dale Schaar, Janice Butchko, Tracey Iraca, Stephanie Searle

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PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex Autor Ly P. Vu, Fabiana Perna, Lan Wang, Francesca Voza, Maria E. Figueroa, Paul Tempst, Hediye Erdjument-Bromage, Rui Gao, Sisi Chen, Elisabeth Paietta, Tony Deblasio, Ari Melnick, Yan Liu, Xinyang Zhao, Stephen D. Nimer

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Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Autor Josephine Wesely, Andriana G. Kotini, Franco Izzo, Hanzhi Luo, Han Yuan, Jun Sun, Maria Georgomanoli, Asaf Zviran, André G. Deslauriers, Neville Dusaj, Stephen D. Nimer, Christina Leslie, Dan A. Landau, Michael G. Kharas, Eirini P. Papapetrou

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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice Autor Zhigang Zhao, Li Chen, Meelad M. Dawlaty, Feng Pan, Ophelia Weeks, Yuan Zhou, Zeng Cao, Hui Shi, Jiapeng Wang, Li Lin, Shi Chen, Weiping Yuan, Zhaohui Qin, Hongyu Ni, Stephen D. Nimer, Feng-Chun Yang, Rudolf Jaenisch, Peng Jin, Mingjiang Xu

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Combined Use of RT-qPCR and NGS for Identification and Surveillance of SARS-CoV-2 Variants of Concern in Residual Clinical Laboratory Samples in Miami-Dade County, Florida Autor Yamina L. Carattini, Anthony Griswold, Sion Williams, Ranjini Valiathan, Yi Zhou, Bhavarth Shukla, Lilian M. Abbo, Katiuska Parra, Merce Jorda, Stephen D. Nimer, Corneliu Sologon, Hilma R. Gallegos, Roy E. Weiss, Tanira Ferreira, Abdul Memon, Peter G. Paige, Emmanuel Thomas, David M. Andrews

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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity Autor Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah M. Greenblatt, Fan Liu, Concepcion Martinez, Daniel Bilbao, Masai Rains, Pierre-Jacques Hamard, Jun Sun, Afoma C. Umeano, Stephanie Duffort, Chuan Chen, Na Man, Gloria Mas, Luca Tottone, Tulasigeri Totiger, Terrence Bradley, Justin Taylor, Stephan Schürer, Stephen D. Nimer

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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression Autor Gloria Mas, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja, Daniel Karl, Felipe Beckedorff, Francesco Tamiro, Chuan Chen, Stephanie Duffort, Hidehiro Itonaga, Adnan K. Mookhtiar, Kranthi Kunkalla, Alfredo M. Valencia, Clayton K. Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Lluis Morey, Daniel Bilbao, Stephen D. Nimer

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HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia Autor Ganqian Zhu, Huacheng Luo, Yang Feng, Olga A. Guryanova, Jianfeng Xu, Shi Chen, Qian Lai, Arati Sharma, Bing Xu, Zhigang Zhao, Ru Feng, Hongyu Ni, David Claxton, Ying Guo, Ruben A. Mesa, Yi Qiu, Feng-Chun Yang, Wei Li, Stephen D. Nimer, Suming Huang, Mingjiang Xu

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Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q) Autor Pierre Fenaux, Aristoteles Giagounidis, Dominik Selleslag, Odile Beyne-Rauzy, Moshe Mittelman, Petra Muus, Stephen D. Nimer, Eva Hellström-Lindberg, Bayard L. Powell, Agnes Guerci-Bresler, Mikkael A. Sekeres, H. Joachim Deeg, Consuelo del Cañizo, Peter L. Greenberg, Jamile M. Shammo, Barry Skikne, Xujie Yu, Alan F. List

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A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species Autor Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric Sturgill, Sarah Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Rodina, John Koren III, Michael W. Becker, Charles M. Rudin, Ari Melnick, Ross L. Levine, Gail J. Roboz, Stephen D. Nimer, Gabriela Chiosis, Monica L. Guzman

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Loss of Asxl2 leads to myeloid malignancies in mice Autor Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang, Mingjiang Xu, Feng-Chun Yang

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p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia Autor Na Man, Gloria Mas, Daniel L. Karl, Jun Sun, Fan Liu, Qin Yang, Miguel Torres-Martin, Hidehiro Itonaga, Concepcion Martinez, Shi Chen, Ye Xu, Stephanie Duffort, Pierre-Jacques Hamard, Chuan Chen, Beth E. Zucconi, Luisa Cimmino, Feng-Chun Yang, Mingjiang Xu, Philip A. Cole, Maria E. Figueroa, Stephen D. Nimer

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MSI2 is required for maintaining activated myelodysplastic syndrome stem cells Autor James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S. Barlowe, Alexendar R. Perez, Benjamin H. Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J. Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M. Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D. Nimer, Michael G. Kharas

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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia Autor John P. Brabson, Tiffany Leesang, Yoon Sing Yap, Jingjing Wang, Minh Q. Lam, Byron Fang, Igor Dolgalev, Daniela A. Barbieri, Victoria Strippoli, Carolina P. Bañuelos, Sofia Mohammad, Peter Lyon, Sana Chaudhry, Dane Donich, Anna Swirski, Evan Roberts, Ivelisse Diaz, Daniel Karl, Helena Gomes Dos Santos, Ramin Shiekhattar, Benjamin G. Neel, Stephen D. Nimer, Ramiro E. Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino

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Toward a more patient‐centered drug development process in clinical trials for patients with myelodysplastic syndromes/neoplasms (MDS): Practical considerations from the Internatio... Autor Fabio Efficace, Rena Buckstein, Gregory A. Abel, Johannes M. Giesinger, Pierre Fenaux, Jan Philipp Bewersdorf, Andrew M. Brunner, Rafael Bejar, Uma Borate, Amy E. DeZern, Peter Greenberg, Gail J. Roboz, Michael R. Savona, Francesco Sparano, Jacqueline Boultwood, Rami Komrokji, David A. Sallman, Zhuoer Xie, Guillermo Sanz, Hetty E. Carraway, Justin Taylor, Stephen D. Nimer, Matteo Giovanni Della Porta, Valeria Santini, Maximilian Stahl, Uwe Platzbecker, Mikkael A. Sekeres, Amer M. Zeidan

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Methylation of dual-specificity phosphatase 4 controls cell differentiation Autor Hairui Su, Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo, Juliana Xavier-Ferrucio, Shuiling Jin, Ngoc-Tung Tran, Szu-Mam Liu, Chiao-Wang Sun, Yongxia Zhu, Qing Zhao, Yuling Chen, LouAnn Cable, Yudao Shen, Jing Liu, Cheng-Kui Qu, Xiaosi Han, Christopher A. Klug, Ravi Bhatia, Yabing Chen, Stephen D. Nimer, Y. George Zheng, Camelia Iancu-Rubin, Jian Jin, Haiteng Deng, Diane S. Krause, Jenny Xiang, Amit Verma, Minkui Luo, Xinyang Zhao

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