Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure by Natasha N. Duggan, Tatjana Dragic, Sumit K. Chanda, Lars Pache

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In silico gene prioritization by integrating multiple data sources. by Yixuan Chen, Wenhui Wang, Yingyao Zhou, Robert Shields, Sumit K Chanda, Robert C Elston, Jing Li

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Sensor Sensibility—HIV-1 and the Innate Immune Response by Xin Yin, Simon Langer, Zeli Zhang, Kristina M. Herbert, Sunnie Yoh, Renate König, Sumit K. Chanda

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A Short Hairpin RNA Screen of Interferon-Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response by Jianqing Li, Steve C. Ding, Hyelim Cho, Brian C. Chung, Michael Gale, Sumit K. Chanda, Michael S. Diamond

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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. by Jeffrey T Irelan, Ana Gutierrez Del Arroyo, Abel Gutierrez, Gordon Peters, Kim C Quon, Loren Miraglia, Sumit K Chanda

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. by Wei Li, Mario H Bengtson, Axel Ulbrich, Akio Matsuda, Venkateshwar A Reddy, Anthony Orth, Sumit K Chanda, Serge Batalov, Claudio A P Joazeiro

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Identification of Polo-like kinases as potential novel drug targets for influenza A virus by Marie O. Pohl, Jessica von Recum-Knepper, Ariel Rodriguez-Frandsen, Caroline Lanz, Emilio Yángüez, Stephen Soonthornvacharin, Thorsten Wolff, Sumit K. Chanda, Silke Stertz

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Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets by Kuoyuan Cheng, Laura Martin‐Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin

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Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu by Prashant Jain, Guney Boso, Simon Langer, Stephen Soonthornvacharin, Paul D. De Jesus, Quy Nguyen, Kevin C. Olivieri, Alex J. Portillo, Sunnie M. Yoh, Lars Pache, Sumit K. Chanda

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Synthetic lethality-based prediction of anti-SARS-CoV-2 targets by Lipika R. Pal, Kuoyuan Cheng, Nishanth Ulhas Nair, Laura Martin-Sancho, Sanju Sinha, Yuan Pu, Laura Riva, Xin Yin, Fiorella Schischlik, Joo Sang Lee, Sumit K. Chanda, Eytan Ruppin

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The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription by Simon Langer, Xin Yin, Arturo Diaz, Alex J. Portillo, David E. Gordon, Umu H. Rogers, John M. Marlett, Nevan J. Krogan, John A. T. Young, Lars Pache, Sumit K. Chanda

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A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor. by Charlotte A Stoneham, Simon Langer, Paul D De Jesus, Jacob M Wozniak, John Lapek, Thomas Deerinck, Andrea Thor, Lars Pache, Sumit K Chanda, David J Gonzalez, Mark Ellisman, John Guatelli

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Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. by Fuqu Yu, Josephine N Harada, Helen J Brown, Hongyu Deng, Moon Jung Song, Ting-Ting Wu, Juran Kato-Stankiewicz, Christian G Nelson, Jeffrey Vieira, Fuyuhiko Tamanoi, Sumit K Chanda, Ren Sun

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HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses by Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter

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Drug target prediction through deep learning functional representation of gene signatures by Hao Chen, Frederick J. King, Bin Zhou, Yu Wang, Carter J. Canedy, Joel Hayashi, Yang Zhong, Max W. Chang, Lars Pache, Julian L. Wong, Yong Jia, John Joslin, Tao Jiang, Christopher Benner, Sumit K. Chanda, Yingyao Zhou

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Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo by Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda

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Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ. by Amanda M Opaluch, Monika Schneider, Chih-yuan Chiang, Quy T Nguyen, Ana M Maestre, Lubbertus C F Mulder, Ismael Secundino, Paul D De Jesus, Renate König, Viviana Simon, Victor Nizet, Graham MacLeod, Susannah Varmuza, Ana Fernandez-Sesma, Sumit K Chanda

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Host cell factors in HIV replication: meta-analysis of genome-wide studies. by Frederic D Bushman, Nirav Malani, Jason Fernandes, Iván D'Orso, Gerard Cagney, Tracy L Diamond, Honglin Zhou, Daria J Hazuda, Amy S Espeseth, Renate König, Sourav Bandyopadhyay, Trey Ideker, Stephen P Goff, Nevan J Krogan, Alan D Frankel, John A T Young, Sumit K Chanda

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SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. by Pinar Mesci, Janaina S de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W Adams, Simoni H Avansini, Roberto H Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A Szeto, Gabriela Goldberg, Patrick T Bruck, Fabio Papes, Sumit K Chanda, Alysson R Muotri

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SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir by Pinar Mesci, Janaina S. de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W. Adams, Simoni H. Avansini, Roberto H. Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A. Szeto, Gabriela Goldberg, Patrick T. Bruck, Fabio Papes, Sumit K. Chanda, Alysson R. Muotri

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