Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers by Martin Liptay, Joana S. Barbosa, Sven Rottenberg, Sven Rottenberg

Get full text

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response by Paola Francica, Sven Rottenberg

Get full text

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids by Mariana Paes Dias, Sven Rottenberg, Jos Jonkers

Get full text

Chrysalis: decoding tissue compartments in spatial transcriptomics with archetypal analysis by Demeter Túrós, Jelica Vasiljevic, Kerstin Hahn, Sven Rottenberg, Alberto Valdeolivas

Get full text

Individualized Pooled CRISPR/Cas9 Screenings Identify CDK2 as a Druggable Vulnerability in a Canine Mammary Carcinoma Patient by Marine Inglebert, Martina Dettwiler, Chang He, Enni Markkanen, Lennart Opitz, Arunasalam Naguleswaran, Sven Rottenberg

Get full text

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus by Vaiva Gradauskaite, Marine Inglebert, John Doench, Melanie Scherer, Martina Dettwiler, Marianne Wyss, Neeta Shrestha, Sven Rottenberg, Philippe Plattet

Get full text

CRISPR/Cas9-Mediated Targeting of BPV-1-Transformed Primary Equine Sarcoid Fibroblasts by Anne Monod, Christoph Koch, Christoph Jindra, Maarten Haspeslagh, Denise Howald, Christian Wenker, Vinzenz Gerber, Sven Rottenberg, Kerstin Hahn

Get full text

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. by Serge A L Zander, Wendy Sol, Lee Greenberger, Yixian Zhang, Olaf van Tellingen, Jos Jonkers, Piet Borst, Sven Rottenberg

Get full text

TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata by Francis Brühlmann, Carmen Perry, Charlotte Griessen, Kapila Gunasekera, Jean-Louis Reymond, Arunasalam Naguleswaran, Sven Rottenberg, Kerry Woods, Philipp Olias

Get full text

Haploid genetic screens identify genetic vulnerabilities to microtubule‐targeting agents by Nora M. Gerhards, Vincent A. Blomen, Merve Mutlu, Joppe Nieuwenhuis, Denise Howald, Charlotte Guyader, Jos Jonkers, Thijn R. Brummelkamp, Sven Rottenberg

Get full text

Establishment of Primary Cell Cultures from Canine Oral Melanomas via Fine-Needle Aspiration: A Novel Tool for Tumorigenesis and Cancer Progression Studies by Adriana Lo Giudice, Ilaria Porcellato, Martina Pellegrini, Sven Rottenberg, Chang He, Alfredo Dentini, Giulia Moretti, Monica Cagiola, Luca Mechelli, Elisabetta Chiaradia, Chiara Brachelente

Get full text

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas by Khyati Meghani, Walker Fuchs, Alexandre Detappe, Pascal Drané, Ewa Gogola, Sven Rottenberg, Jos Jonkers, Ursula Matulonis, Elizabeth M. Swisher, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury

Get full text

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer by Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R. Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg

Get full text

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells by Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt

Get full text

PatchSorter: a high throughput deep learning digital pathology tool for object labeling by Cédric Walker, Tasneem Talawalla, Robert Toth, Akhil Ambekar, Kien Rea, Oswin Chamian, Fan Fan, Sabina Berezowska, Sven Rottenberg, Anant Madabhushi, Marie Maillard, Laura Barisoni, Hugo Mark Horlings, Andrew Janowczyk

Get full text

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites by Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias

Get full text

Artificial Intelligence to Predict the BRAF V595E Mutation in Canine Urinary Bladder Urothelial Carcinomas by Leonore Küchler, Caroline Posthaus, Kathrin Jäger, Franco Guscetti, Louise van der Weyden, Wolf von Bomhard, Jarno M. Schmidt, Dima Farra, Heike Aupperle-Lellbach, Alexandra Kehl, Sven Rottenberg, Simone de Brot

Get full text

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity by Jordan R. Becker, Raquel Cuella-Martin, Marco Barazas, Rui Liu, Catarina Oliveira, Antony W. Oliver, Kirstin Bilham, Abbey B. Holt, Andrew N. Blackford, Jörg Heierhorst, Jos Jonkers, Sven Rottenberg, J. Ross Chapman

Get full text

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining by Paola Francica, Merve Mutlu, Vincent A. Blomen, Catarina Oliveira, Zuzanna Nowicka, Anika Trenner, Nora M. Gerhards, Peter Bouwman, Elmer Stickel, Maarten L. Hekkelman, Lea Lingg, Ismar Klebic, Marieke van de Ven, Renske de Korte-Grimmerink, Denise Howald, Jos Jonkers, Alessandro A. Sartori, Wojciech Fendler, J. Ross Chapman, Thijn Brummelkamp, Sven Rottenberg

Get full text

Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics by Alberto Valdeolivas, Bettina Amberg, Nicolas Giroud, Marion Richardson, Eric J. C. Gálvez, Solveig Badillo, Alice Julien-Laferrière, Demeter Túrós, Lena Voith von Voithenberg, Isabelle Wells, Benedek Pesti, Amy A. Lo, Emilio Yángüez, Meghna Das Thakur, Michael Bscheider, Marc Sultan, Nadine Kumpesa, Björn Jacobsen, Tobias Bergauer, Julio Saez-Rodriguez, Sven Rottenberg, Petra C. Schwalie, Kerstin Hahn

Get full text