Biology of secondary leukemia Autor Andrew M. Brunner, Timothy A. Graubert

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P758: INHIBITION OF ATR WITH CERALASERTIB (AZD6738) FOR THE TREATMENT OF PROGRESSIVE OR RELAPSED MYELODYSPLASTIC SYNDROMES AND CHRONIC MYELOMONOCYTIC LEUKEMIA: A PHASE IB/II STUDY Autor A. Brunner, Y. Liu, L. Mendez, J. Garcia, P. Amrein, D. Neuberg, E. Dean, S. Smith, R. Stone, A. Fathi, M. Walter, T. Graubert, M. Jacoby

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Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. Autor Timothy A Graubert, Michelle A Payton, Jin Shao, Richard A Walgren, Ryan S Monahan, John L Frater, Mark A Walshauser, Mike G Martin, Yumi Kasai, Matthew J Walter

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Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome Autor Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter

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Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity Autor van Galen, Peter, Hovestadt, Volker, Wadsworth II, Marc H., Hughes, Travis K., Griffin, Gabriel K., Battaglia, Sofia, Verga, Julia A., Stephansky, Jason, Pastika, Timothy J., Lombardi Story, Jennifer, Pinkus, Geraldine S., Pozdnyakova, Olga, Galinsky, Ilene, Stone, Richard M., Graubert, Timothy A., Shalek, Alex K., Aster, Jon C., Lane, Andrew A., Bernstein, Bradley E.

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Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies Autor Melissa Zhao, Scott Ryall, Samuel J. Brody, Amyah C. Harris, Kristin Cabral, Catherine Brownstein, Jaeseung C. Kim, Adam C. Smith, Paola Dal Cin, Rupa Narayan, Kristin Sikkink, Anthony Schmitt, Gabriela S. Hobbs, Amir T. Fathi, Gabriel K. Griffin, Sheila N. J. Sait, Anthony J. Iafrate, Jon C. Aster, Timothy A. Graubert, Valentina Nardi, Adrian M. Dubuc

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Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. Autor Andrew E O Hughes, Vincent Magrini, Ryan Demeter, Christopher A Miller, Robert Fulton, Lucinda L Fulton, William C Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F Conrad, Brian S White, Jin Shao, Daniel C Link, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Matthew J Walter, Timothy A Graubert

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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential Autor Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter, Timothy J. Ley, Daniel C. Link

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Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia Autor Amir T. Fathi, Seth A. Wander, Traci M. Blonquist, Andrew M. Brunner, Philip C. Amrein, Jeffrey Supko, Nicole M. Hermance, Amity L. Manning, Hossein Sadrzadeh, Karen K. Ballen, Eyal C. Attar, Timothy A. Graubert, Gabriela Hobbs, Christelle Joseph, Ashley M. Perry, Meghan Burke, Regina Silver, Julia Foster, Meghan Bergeron, Aura Y. Ramos, Tina T. Som, Kaitlyn M. Fishman, Kristin L. McGregor, Christine Connolly, Donna S. Neuberg, Yi-Bin Chen

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SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS Autor Malcovati, L, Stevenson, K, Papaemmanuil, E, Neuberg, D, Bejar, R, Boultwood, J, Bowen, DT, Campbell, PJ, Ebert, BL, Fenaux, P, Haferlach, T, Heuser, M, Jansen, JH, Komrokji, RS, Maciejewski, JP, Walter, MJ, Fontenay, M, Garcia-Manero, G, Graubert, TA, Karsan, A, Meggendorfer, M, Pellagatti, A, Sallman, DA, Savona, MR, Sekeres, M, Steensma, DP, Tauro, S, Thol, F, Vyas, P, Van de Loosdrecht, AA, Haase, DT, Tuechler, H, Greenberg, PL, Ogawa, S, Hellstrom-Lindberg, ES, Cazzola, M

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups Autor Haase, D, Stevenson, KE, Neuberg, D, Maciejewski, JP, Nazha, A, Sekeres, MA, Ebert, BL, Garcia-Manero, G, Haferlach, C, Haferlach, T, Kern, W, Ogawa, S, Nagata, Y, Yoshida, K, Graubert, TA, Walter, MJ, List, AF, Komrokji, RS, Padron, E, Sallman, D, Papaemmanuil, E, Campbell, PJ, Savona, MR, Seegmiller, A, Adès, L, Fenaux, P, Shih, L-Y, Bowen, D, Groves, MJ, Tauro, S, Fontenay, M, Kosmider, O, Bar-Natan, M, Steensma, D, Stone, R, Heuser, M, Thol, F, Cazzola, M, Malcovati, L, Karsan, A, Ganster, C, Hellström-Lindberg, E, Boultwood, J, Pellagatti, A, Santini, V, Quek, L, Vyas, P, Tüchler, H, Greenberg, PL, Bejar, R, International Working Group For Mds Molecular Prognostic Committee