35336 Effect of Nuclear Soluble Adenylyl Cyclase (sAC) on Melanoma Treatment Response by Jakyung Bang, Marek M. Drozdz, Lauren Dong, Taha Merghoub, Jonathan H. Zippin

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525 Investigating dynamic IDO-Kyn-AhR pathway-induced tumor immunosuppression using imaging modality to optimize AhR therapeutic intervention by Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Inna Serganova, Jonathan F Khan, Mamadou A Bah

Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant by Ning Yang, Aitor Garcia, Cindy Meyer, Thomas Tuschl, Taha Merghoub, Jedd D. Wolchok, Liang Deng

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968 PD-1hiFoxp3-CD4+ tumor-infiltrating T-cell lineage commitment impacts the immunotherapy outcome by Jedd D Wolchok, Taha Merghoub, Roberta Zappasodi, Sara Schad, Benjamin Greenbaum, Levi Mark Mangarin, Stephen Martis, Andrea Orlando

Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model by Sadna Budhu, Kwanghee Kim, Wesley Yip, Stephen La Rosa, Sylvia Jebiwott, Liqun Cai, Aliya Holland, Jasmine Thomas, Dina Preise, Alex Somma, Benjamin Gordon, Avigdor Scherz, Jedd D. Wolchok, Jedd D. Wolchok, Jedd D. Wolchok, Joseph Erinjeri, Taha Merghoub, Taha Merghoub, Jonathan A. Coleman, Jonathan A. Coleman

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789 Immune checkpoint blockade augments cyclophosphamide induced anti-tumor immunity by expanding effector CD8+ T cell clones in a preclinical melanoma model by Alan N Houghton, Jedd D Wolchok, Taha Merghoub, Daniel Hirschhorn, Linda Hamadene, Yacine Marouf, Allison B Warner, Mariam M George, Nicholas J Ceglia

1444 Pharmacologic LDH inhibition redirects intratumoral glucose consumption and improves response to CTLA-4 blockade by Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Roberta Zappasodi, Svena Verma, Inna Serganova, Lauren Dong, Levi Mark Mangarin, Yacine Marouf, Jonathan F Khan

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. by Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng

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Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer by Aditi Gupta, Sadna Budhu, Kelly Fitzgerald, Rachel Giese, Adam O. Michel, Aliya Holland, Luis Felipe Campesato, Jacques van Snick, Catherine Uyttenhove, Gerd Ritter, Jedd D. Wolchok, Taha Merghoub

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Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer by Elizabeth Comen, Sadna Budhu, Yuval Elhanati, David Page, Teresa Rasalan-Ho, Erika Ritter, Phillip Wong, George Plitas, Sujata Patil, Edi Brogi, Maxine Jochelson, Yolanda Bryce, Stephen B. Solomon, Larry Norton, Taha Merghoub, Heather L. McArthur

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TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models by Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens

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Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases by David B. Page, Kathryn Beal, Stefanie N. Linch, Kateri J. Spinelli, Micaela Rodine, Darragh Halpenny, Shanu Modi, Sujata Patil, Robert J. Young, Thomas Kaley, Taha Merghoub, David Redmond, Phillip Wong, Christopher A. Barker, Adi Diab, Larry Norton, Heather L. McArthur

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FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer by Yifan Tai, Angela Chow, Seoyoung Han, Courtney Coker, Wanchao Ma, Yifan Gu, Valeria Estrada Navarro, Manoj Kandpal, Hanina Hibshoosh, Kevin Kalinsky, Katia Manova-Todorova, Anton Safonov, Elaine M Walsh, Mark Robson, Larry Norton, Richard Baer, Taha Merghoub, Anup K Biswas, Swarnali Acharyya

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Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial by Dmitriy Zamarin, Taha Merghoub, Yanyun Li, Travis J Hollmann, Jason A Konner, Qin Zhou, Carol Aghajanian, Roisin E O’Cearbhaill, Aliya Holland, Rachel N Grisham, Keith L Knutson, Sven Walderich, Alexia E Iasonos, Jean M Torrisi, Lewis F Chesebrough, Autumn S Mcdonnell, Jacqueline M Gallagher, Courtney L Erskine

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Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade by Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Ricardo Gomez, Fadi Samaan, Yu-Jui Ho, Luis Felipe Campesato, Levi Mangarin, John Fak, Nathan Suek, Aliya Holland, Cailian Liu, Mohsen Abu-Akeel, Yonina Bykov, Hong Zhong, Kelly Fitzgerald, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Katherine S. Panageas, Olivier de Henau, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok

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In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response by Aditi Sahu, Kivanc Kose, Lukas Kraehenbuehl, Candice Byers, Aliya Holland, Teguru Tembo, Anthony Santella, Anabel Alfonso, Madison Li, Miguel Cordova, Melissa Gill, Christi Fox, Salvador Gonzalez, Piyush Kumar, Amber Weiching Wang, Nicholas Kurtansky, Pratik Chandrani, Shen Yin, Paras Mehta, Cristian Navarrete-Dechent, Gary Peterson, Kimeil King, Stephen Dusza, Ning Yang, Shuaitong Liu, William Phillips, Pascale Guitera, Anthony Rossi, Allan Halpern, Liang Deng, Melissa Pulitzer, Ashfaq Marghoob, Chih-Shan Jason Chen, Taha Merghoub, Milind Rajadhyaksha

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Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer by Drew M Pardoll, Julie R Brahmer, Patrick M Forde, Jarushka Naidoo, David Jones, Taha Merghoub, Suzanne Topalian, Gary Rosner, Valsamo Anagnostou, Hok Yee Chan, Franco Verde, Daphne Wang, Matthew D Hellmann, Victor E Velculescu, James R White, Tricia R Cottrell, Joshua E Reuss, Stephen Broderick, Kellie N Smith, Marianna Zahurak, Mara Lanis, Joseph C Murray, Caroline McCarthy, Richard Battafarano, Errol Bush, Malcolm Brock, Jinny Ha, Janis Taube, Peter Illei, Ben Levy, Jamie E Chaft

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878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants by David Ng, Katherine S Panageas, Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Olivier De Henau, Yanyun Li, Billel Gasmi, Cailian Liu, Sara Schad, Rebekka Duhen, Andrew D Weinberg, Mathieu Gigoux, David Redmond, David Schroder, Andrew Chow, Daniel Hirschhorn, Lukas kraehenbuehl, Isabell Schulze, Aliya Holland, Jean Albrengues, Mikala Egeblad, Arshi Arora, Xue-Yan He, Linda Hamadene, Travis Hollmann, Jacob M Ricca, Levi Mark B Mangarin, Anne-Laure Flamar, Heyjin Choi, Czrina A Cortez, Allison Betof Warner, Gabrielle A Rizzuto, Christine N Spencer

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death by Udo S Gaipl, Dmitriy Zamarin, Felipe Prosper, Francesco M Marincola, Alessandra Cesano, Howard L Kaufman, Laurence Zitvogel, Tim Illidge, Taha Merghoub, Sandra Demaria, Abhishek D Garg, Patrizia Agostinis, James W Hodge, George Coukos, Akseli Hemminki, Öystein Rekdal, Jian Han, John Stagg, Sarah Warren, Lorenzo Galluzzi, Dobrin Draganov, Silvia C Formenti, Mark J Smyth, Radek Špíšek, Michael T Lotze, Takahiro Yamazaki, Guido Kroemer, Daolin Tang, Eric Deutsch, Jitka Fucikova, Sofia R Gameiro, Ilio Vitale, Sandy Adjemian, Aitziber Buqué Martinez, Timothy A Chan, Richard L Edelson, Lucia Gabriele, Encouse Golden, Kevin J Harrington, Dewan Md Sakib Hossain, Michael Karin, Oliver Kepp, Juan Jose Lasarte, Sherene Loi, Gwenola Manic, Alan A Melcher, Karen L Mossman, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Bryan E Strauss, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele

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