ABCA7 and Pathogenic Pathways of Alzheimer’s Disease by Tomonori Aikawa, Marie-Louise Holm, Takahisa Kanekiyo

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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease by Yasuteru Inoue, Francis Shue, Guojun Bu, Takahisa Kanekiyo

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Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies by Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu

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Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neu... by Ming Gan, Peizhou Jiang, Pamela McLean, Takahisa Kanekiyo, Guojun Bu

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A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells by Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo, Takahisa Kanekiyo

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ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation by Tomonori Aikawa, Yingxue Ren, Marie-Louise Holm, Yan W. Asmann, Amer Alam, Michael L. Fitzgerald, Guojun Bu, Takahisa Kanekiyo

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Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in AppNL−G-F mice by Ni Wang, Tammee M. Parsons, Yingxue Ren, Yining Pan, Aishe Kurti, Skylar C. Starling, Chinenye Muolokwu, Jagdish Singh, Takahisa Kanekiyo

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Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. by Rodrigo A Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo LaDu, Guojun Bu

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Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids by Mark Marzano, Julie Bejoy, Mujeeb R. Cheerathodi, Li Sun, Sara B. York, Jing Zhao, Takahisa Kanekiyo, Guojun Bu, David G. Meckes, Yan Li

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A mutant methionyl-tRNA synthetase-based toolkit to assess induced-mesenchymal stromal cell secretome in mixed-culture disease models by Jeremy D. Burgess, Danilyn Amerna, Emily S. Norton, Tammee M. Parsons, Ralph B. Perkerson, Ayman H. Faroqi, Zbigniew K. Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos, Pamela J. McLean

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APOE2 is associated with longevity independent of Alzheimer’s disease by Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M Sullivan, G William Rebeck, John D Fryer, Michael G Heckman, Guojun Bu

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APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids by Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu

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Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage by Kshama Gupta, Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess, Yingxue Ren, Pamela J. McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K. Wszolek, Abba C. Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo

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LRP1 is a neuronal receptor for α-synuclein uptake and spread by Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao

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Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease by Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras Minhas, Matthew Pinto, Lee-Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, Guojun Bu, Benjamin Gateno, Kyeong-Ok Chang, Karl A. Nath, Emirhan Nemutlu, Petras Dzeja, Yuan-Ping Pang, Duy H. Hua, Eugenia Trushina

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Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice by Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C. Starling, Ralph B. Perkerson, Bhaskar Roy, Astrid C. Quintero, Tammee M. Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E. Tanzi, Takahisa Kanekiyo

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Alterations of PINK1-PRKN signaling in mice during normal aging by Zahra Baninameh, Jens O. Watzlawik, Xu Hou, Tyrique Richardson, Nicholas W. Kurchaba, Tingxiang Yan, Damian N. Di Florio, DeLisa Fairweather, Lu Kang, Justin H. Nguyen, Takahisa Kanekiyo, Dennis W. Dickson, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Matthew S. Goldberg, Ian G. Ganley, Kelly L. Stauch, Fabienne C. Fiesel, Wolfdieter Springer

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LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 by Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo

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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids by Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu

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Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids by Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu

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