Editorial: Characterization of HIV-1 variants: implications for HIV-1 prevention, treatment and cure nork Jaclyn K. Mann, Marcel Tongo, Takamasa Ueno, Takamasa Ueno

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Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? nork Philip Mwimanzi, Tristan J. Markle, Mark A. Brockman, Takamasa Ueno

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Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate nork George P. Judicate, Godfrey Barabona, Doreen Kamori, Macdonald Mahiti, Toong Seng Tan, Seiya Ozono, Amina Shaban Mgunya, Takeo Kuwata, Shuzo Matsushita, Bruno Sunguya, Bruno Sunguya, Eligius Lyamuya, Eligius Lyamuya, Kenzo Tokunaga, Kenzo Tokunaga, Takamasa Ueno, Takamasa Ueno

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Further Characterization of the Antiviral Transmembrane Protein MARCH8 nork Takuya Tada, Yanzhao Zhang, Dechuan Kong, Michiko Tanaka, Weitong Yao, Masanori Kameoka, Takamasa Ueno, Hideaki Fujita, Kenzo Tokunaga

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Hypertension and immune activation in antiretroviral therapy naïve people living with human immunodeficiency virus nork Tosi M. Mwakyandile, Grace A. Shayo, Philip G. Sasi, Ferdinand M. Mugusi, Godfrey Barabona, Takamasa Ueno, Eligius F. Lyamuya

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Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians nork Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George P. Judicate, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno

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Hypertension and traditional risk factors for cardiovascular diseases among treatment naïve HIV- infected adults initiating antiretroviral therapy in Urban Tanzania nork Tosi M. Mwakyandile, Grace A. Shayo, Philip G. Sasi, Ferdinand M. Mugusi, Godfrey Barabona, Takamasa Ueno, Eligius F. Lyamuya

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The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement. nork Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T Fackler, Seiji Okada, Shinya Suzu

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CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. nork Chihiro Motozono, John J Miles, Zafrul Hasan, Hiroyuki Gatanaga, Stanley C Meribe, David A Price, Shinichi Oka, Andrew K Sewell, Takamasa Ueno

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Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences nork Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno

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SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity nork Seiya Ozono, Yanzhao Zhang, Hirotaka Ode, Kaori Sano, Toong Seng Tan, Kazuo Imai, Kazuyasu Miyoshi, Satoshi Kishigami, Takamasa Ueno, Yasumasa Iwatani, Tadaki Suzuki, Kenzo Tokunaga

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Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania nork Doreen Kamori, Agricola Joachim, Mucho Mizinduko, Godfrey Barabona, Macdonald Mahiti, Upendo Kibwana, Mtebe Majigo, Salim Masoud, Ambele M. Mwandigha, Takamasa Ueno, Elia Mmbaga, Eligius Lyamuya

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Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV nork Isaac Ngare, Toong Seng Tan, Mako Toyoda, Takeo Kuwata, Soichiro Takahama, Eriko Nakashima, Naoya Yamasaki, Chihiro Motozono, Teruhisa Fujii, Rumi Minami, Godfrey Barabona, Takamasa Ueno

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Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity nork Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich Göttlinger, Bruce D. Walker, Takamasa Ueno, Andrés Finzi, Zabrina L. Brumme, Mark A. Brockman

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Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. nork Jingyan Chen, Nadine Tibroni, Daniel Sauter, Johanna Galaski, Toshiyuki Miura, Galit Alter, Birthe Mueller, Claudia Haller, Bruce D Walker, Frank Kirchhoff, Zabrina L Brumme, Takamasa Ueno, Oliver T Fackler

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Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cyto... nork Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Godfrey Barabona, Akiko Yonekawa, Nobuyuki Shimono, Rumi Minami, Yoji Nagasaki, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Shuzo Matsushita, Takeo Kuwata, Takamasa Ueno

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The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition nork Chihiro Motozono, Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Yoshihiko Goto, Yoshiki Aritsu, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Seiji Okada, Keiko Udaka, Mizuki Kitamatsu, Hiroyuki Kishi, Takamasa Ueno

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Neutralizing immunity against coronaviruses in Tanzanian health care workers nork Godfrey Barabona, Isaac Ngare, Doreen Kamori, Lilian Nkinda, Yusuke Kosugi, Ambele Mawazo, Rayi Ekwabi, Gloria Kinasa, Harrison Chuwa, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato, Bruno Sunguya, Takamasa Ueno

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Acquired HIV drug resistance among children and adults receiving antiretroviral therapy in Tanzania: a national representative survey protocol nork Said Aboud, Jeremiah Mushi, Bruno F Sunguya, Mucho Mizinduko, Beatrice Mutayoba, Joan Rugemalila, Doreen Kamori, Werner Maokola, Godfrey Barabona, Salim Masoud, Linda B Mlunde, Ritah Francis Mutagonda, George Ruhago, Veryeh Sambu, Takamasa Ueno, Prosper Njau, Tumaini Nagu

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HIV viral suppression in the era of dolutegravir use: Findings from a national survey in Tanzania. nork Doreen Kamori, Godfrey Barabona, Werner Maokola, Joan Rugemalila, Macdonald Mahiti, Mucho Mizinduko, Amon Sabasaba, George Ruhago, Linda Mlunde, Salim S Masoud, Davis Amani, Erick Mboya, Sabina Mugusi, Anath Rwebembera, George Mgomella, Sarah Asiimwe, Beatrice Mutayoba, Prosper Njau, Takamasa Ueno, Andrea Pembe, Bruno Sunguya

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