Roles of peptidyl prolyl isomerase Pin1 in viral propagation Tekijä Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi

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A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions Tekijä Masaru Yokoyama, Tomoichiro Oka, Hirotaka Takagi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yukinobu Tohya, Hironori Sato

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Small-Molecule-Induced Activation of Cellular Respiration Inhibits Biofilm Formation and Triggers Metabolic Remodeling in Staphylococcus aureus Tekijä Ken-ichi Okuda, Satomi Yamada-Ueno, Yutaka Yoshii, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Yoshimitsu Mizunoe, Yuki Kinjo

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Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies Tekijä Yu Takahashi, Yu Inoue, Shintaro Sato, Takayoshi Okabe, Hirotatsu Kojima, Hiroshi Kiyono, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato

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Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells Tekijä Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano

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Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target Tekijä Takeshi Yamamotoya, Yusuke Nakatsu, Machi Kanna, Shun Hasei, Yukino Ohata, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi

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Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer Tekijä Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino, Tomoyuki Ohe

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Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2[S] Tekijä Megumi Tarui, Hideo Shindou, Kazuo Kumagai, Ryo Morimoto, Takeshi Harayama, Tomomi Hashidate, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Takahide Nagase, Takao Shimizu

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High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway Tekijä Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano

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Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics Tekijä Yutaka Yoshii, Ken-ichi Okuda, Satomi Yamada, Mari Nagakura, Shinya Sugimoto, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Takeo Iwamoto, Kazuyoshi Kuwano, Yoshimitsu Mizunoe

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Pathological Role of Pin1 in the Development of DSS-Induced Colitis Tekijä Yasuka Matsunaga, Shun Hasei, Takeshi Yamamotoya, Hiroaki Honda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Yusuke Nakatsu

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A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response[S] Tekijä Ke Liu, Naoko Kunii, Megumi Sakuma, Atsumi Yamaki, Satoru Mizuno, Mayu Sato, Hiromichi Sakai, Sayaka Kado, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuhito Shirai, Fumio Sakane

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Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation Tekijä Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano

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A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model Tekijä Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo

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Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti Tekijä Kazue Inaba, Kana Ebihara, Miki Senda, Ryunosuke Yoshino, Chisako Sakuma, Kotaro Koiwai, Daisuke Takaya, Chiduru Watanabe, Akira Watanabe, Yusuke Kawashima, Kaori Fukuzawa, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Nozomi Uemura, Shinji Kasai, Hirotaka Kanuka, Takashi Nishimura, Kodai Watanabe, Hideshi Inoue, Yuuta Fujikawa, Teruki Honma, Takatsugu Hirokawa, Toshiya Senda, Ryusuke Niwa

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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties Tekijä Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima

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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Tekijä Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu

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