Development of selective CBP/P300 benzoxazepine bromodomain inhibitors by Popp, T, Tallant, C, Rogers, C, Fedorov, O, Brennan, P, Müller, S, Knapp, S, Bracher, F

Effect of BET missense mutations on bromodomain function, inhibitor binding and stability by Lori, L, Pasquo, A, Lori, C, Petrosino, M, Chiaraluce, R, Tallant, C, Knapp, S, Consalvi, V

Conformational plasticity of the ULK3 kinase domain by Mathea, S, Salah, E, Tallant, C, Chatterjee, D, Berger, B-T, Konietzny, R, Müller-Knapp, S, Kessler, BM, Knapp, S

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces by Brennan, P, Bowkett, D, Talon, R, Tallant, C, Schofield, C, Bruton, G, Von Delft, F, Knapp, S

Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. by Tallant, C, Valentini, E, Fedorov, O, Overvoorde, L, Ferguson, F, Filippakopoulos, P, Svergun, D, Knapp, S, Ciulli, A

Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex by Sutherell, C, Tallant, C, Monteiro, O, Yapp, C, Fuchs, J, Fedorov, O, Siejka, P, Müller, S, Knapp, S, Brenton, J, Brennan, P, Ley, S

Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose non-fermenting complex. by Sutherell, C, Tallant, C, Monteiro, O, Yapp, C, Fuchs, J, Fedorov, O, Siejka, P, Müller, S, Knapp, S, Brenton, J, Brennan, P, Ley, S

Structure of the human protein kinase ZAK in complex with vemurafenib. by Mathea, S, Abdul Azeez, K, Salah, E, Tallant, C, Wolfreys, F, Konietzny, R, Fischer, R, Lou, H, Brennan, P, Schnapp, G, Pautsch, A, Kessler, B, Turk, B, Knapp, S

An activity-based probe targeting non-catalytic, highly conserved amino acid residues within bromodomains by D'Ascenzio, M, Pugh, KM, Konietzny, R, Berridge, G, Tallant, C, Hashem, S, Monteiro, O, Thomas, JR, Schirle, M, Knapp, S, Marsden, B, Fedorov, O, Bountra, C, Kessler, BM, Brennan, PE

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. by Hammitzsch, A, Tallant, C, Fedorov, O, O'Mahony, A, Brennan, P, Hay, D, Martinez, F, Al-Mossawi, M, de Wit, J, Vecellio, M, Wells, C, Wordsworth, B, Müller, S, Knapp, S, Bowness, P

Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies. by Igoe, N, Bayle, E, Fedorov, O, Tallant, C, Savitsky, P, Rogers, C, Owen, D, Deb, G, Somervaille, T, Andrews, D, Jones, N, Cheasty, A, Ryder, H, Brennan, P, Müller, S, Knapp, S, Fish, P

Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins by Igoe, N, Bayle, E, Tallant, C, Fedorov, O, Meier, J, Savitsky, P, Rogers, C, Morias, Y, Scholze, S, Boyd, H, Cunoosamy, D, Andrews, D, Cheasty, A, Brennan, P, Müller, S, Knapp, S, Fish, P

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains by Hay, D, Fedorov, O, Martin, S, Singleton, D, Tallant, C, Wells, C, Picaud, S, Philpott, M, Monteiro, O, Rogers, C, Conway, S, Rooney, T, Tumber, A, Yapp, C, Filippakopoulos, P, Bunnage, M, Müller, S, Knapp, S, Schofield, C, Brennan, P

Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains by Sekirnik, AR, Reynolds, JK, See, L, Bluck, JP, Scorah, AR, Tallant, C, Lee, B, Leszczynska, KB, Grimley, RL, Storer, RI, Malattia, M, Crespillo, S, Caria, S, Duclos, S, Hammond, EM, Knapp, S, Morris, GM, Duarte, F, Biggin, PC, Conway, SJ

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease by Batson, J, Toop, HD, Redondo, ACC, Babaei-Jadidi, R, Chaikuad, A, Wearmouth, SF, Gibbons, B, Allen, C, Tallant, C, Zhang, J, Du, C, Hancox, JC, Hawtrey, T, Da Rocha, J, Griffith, R, Knapp, S, Bates, DO, Morris, JC

BET inhibition as a new strategy for the treatment of gastric cancer by Montenegro, R, Clark, P, Howarth, A, Wan, X, Ceroni, A, Siejka, P, Nunez-Alonso, G, Monteiro, O, Rogers, C, Gamble, V, Burbano, R, Brennan, P, Tallant, C, Ebner, D, Fedorov, O, O'Neill, E, Knapp, S, Dixon, D, Müller, S

Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B by Chen, P, Chaikuad, A, Bamborough, P, Bantscheff, M, Bountra, C, Chung, C, Fedorov, O, Grandi, P, Jung, D, Lesniak, R, Lindon, M, Müller, S, Philpott, M, Prinjha, R, Rogers, C, Selenski, C, Tallant, C, Werner, T, Willson, T, Knapp, S, Drewry, D

Discovery and optimization of a selective ligand for the Switch/Sucrose Non-Fermenting-related bromodomains of Polybromo protein-1 by the use of virtual screening and hydration ana... by Myrianthopoulos, V, Gaboriaud-Kolar, N, Tallant, C, Hall, M, Grigoriou, S, Brownlee, P, Fedorov, O, Rogers, C, Heidenreich, D, Wanior, M, Drosos, N, Mexia, N, Savitsky, P, Bagratuni, T, Kastritis, E, Terpos, E, Filippakopoulos, P, Müller, S, Skaltsounis, A, Downs, J, Knapp, S, Mikros, E

Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains by Bouché, L, Christ, C, Siegel, S, Fernández-Montalván, A, Holton, S, Fedorov, O, Ter Laak, A, Sugawara, T, Stöckigt, D, Tallant, C, Bennett, J, Monteiro, O, Díaz-Sáez, L, Siejka, P, Meier, J, Pütter, V, Weiske, J, Müller, S, Huber, K, Hartung, I, Haendler, B

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. by Fedorov, O, Castex, J, Tallant, C, Owen, D, Martin, S, Aldeghi, M, Monteiro, O, Filippakopoulos, P, Picaud, S, Trzupek, J, Gerstenberger, B, Bountra, C, Willmann, D, Wells, C, Philpott, M, Rogers, C, Biggin, P, Brennan, P, Bunnage, M, Schüle, R, Günther, T, Knapp, S, Müller, S