Targeting cellular senescence in metabolic disease by Allyson K. Palmer, Tamar Tchkonia, James L. Kirkland

Get full text

Cell senescence, the senescence-associated secretory phenotype, and cancers. by Larissa G P Langhi Prata, Tamar Tchkonia, James L Kirkland

Get full text

Rationale and design of STAMINA: Senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study by Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Jasmin Kuo, Tamara Tchkonia, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz

Get full text

Patients With Coronary Microvascular Dysfunction Have Less Circulating α‐Klotho by Nadia Akhiyat, Ilke Ozcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L. Kirkland, Bradley Lewis, Lilach O. Lerman, Amir Lerman

Get full text

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases by Masayoshi Suda, Karl H. Paul, Tohru Minamino, Jordan D. Miller, Amir Lerman, Georgina M. Ellison-Hughes, Tamar Tchkonia, James L. Kirkland

Get full text

Fat cell precursors from different human fat depots are distinct: Morphological and gene expression profiles by Kirkland, J, Tchkonia, T, Frampton, G, Lenberg, M, Giorgadze, N, Sabban, A, Pirtskhalava, T, Cartwright, M, Gerry, N, Forse, A, Thomou, T, Gileadi, O

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context by Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Amani M. Norling, Afroditi Boulougoura, Theodoros Vichos, Tamara Tchkonia, Aaron Deisinger, Tamar Pirtskhalava, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz

Get full text

Cellular senescence in brain aging and cognitive decline by Areez Shafqat, Saifullah Khan, Mohamed H. Omer, Mahnoor Niaz, Ibrahem Albalkhi, Khaled AlKattan, Ahmed Yaqinuddin, Tamara Tchkonia, James L. Kirkland, Shahrukh K. Hashmi, Shahrukh K. Hashmi, Shahrukh K. Hashmi

Get full text

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility an... by Anoop Nambiar, Dean Kellogg, III, Jaime Justice, Martin Goros, Jonathan Gelfond, Rodolfo Pascual, Shahrukh Hashmi, Michal Masternak, Larissa Prata, Nathan LeBrasseur, Andrew Limper, Stephen Kritchevsky, Nicolas Musi, Tamara Tchkonia, James Kirkland

Get full text

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial by Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators

Get full text

Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy by Hui Tang, Lilach O Lerman, Xiaohui Bian, Tomás P Griffin, Xiangyang Zhu, Md Nahidul Islam, Sabena M Conley, Alfonso Eirin, Paula M O’Shea, Allyson K Palmer, Sandra M Herrmann, Ramila A Mehta, John R Woollard, Andrew D Rule, James L Kirkland, Tamar Tchkonia, Stephen C Textor, Matthew D Griffin, LaTonya J Hickson

Get full text

An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence by Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns

Get full text

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis by Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla

Get full text

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance by Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer

Get full text

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice by Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina

Get full text

Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice by Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina

Get full text