Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy by Helena Verdaguer, Josep Tabernero, Teresa Macarulla

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The importance of dietary fat composition on adipose tissue metabolism by Mª del Puy Portillo, Mª Teresa Macarulla, Valentina Ruiz-Gutiérrez

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Current and emerging anti-angiogenic therapies in gastrointestinal and hepatobiliary cancers by Nadia Saoudi González, Florian Castet, Elena Élez, Teresa Macarulla, Josep Tabernero

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Relationship between changes in microbiota induced by resveratrol and its anti-diabetic effect on type 2 diabetes by Alfredo Fernandez-Quintela, Alfredo Fernandez-Quintela, Alfredo Fernandez-Quintela, María Teresa Macarulla, María Teresa Macarulla, María Teresa Macarulla, Saioa Gómez-Zorita, Saioa Gómez-Zorita, Saioa Gómez-Zorita, Marcela González, Iñaki Milton-Laskibar, Iñaki Milton-Laskibar, Iñaki Milton-Laskibar, María P. Portillo, María P. Portillo, María P. Portillo

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Effect of <i>Gracilaria vermiculophylla</i> Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats by Maitane González-Arceo, Leixuri Aguirre, María Teresa Macarulla, Clàudia Gil-Pitarch, María Luz Martínez-Chantar, María P. Portillo, Saioa Gómez-Zorita

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IMbrave 151: a randomized phase II trial of atezolizumab combined with bevacizumab and chemotherapy in patients with advanced biliary tract cancer by Stephen P. Hack, Wendy Verret, Sohail Mulla, Bo Liu, Yulei Wang, Teresa Macarulla, Zhenggang Ren, Anthony B. El-Khoueiry, Andrew X. Zhu

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Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies by Cristina Martínez-Villaluenga, Elena Peñas, Daniel Rico, Ana Belén Martin-Diana, Maria P. Portillo, Maria Teresa Macarulla, Daniel Antonio de Luis, Jonatan Miranda

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Treatment sequences and prognostic/predictive factors in metastatic pancreatic ductal adenocarcinoma: univariate and multivariate analyses of a real-world study in Europe by Julien Taieb, Thomas Seufferlein, Michele Reni, Daniel H. Palmer, John A. Bridgewater, Antonio Cubillo, Gerald W. Prager, Alice Vermeire, Fabienne Hédouin-Biville, Zhaoyang Teng, Teresa Macarulla

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Population pharmacokinetics of liposomal irinotecan in patients with cancer and exposure–safety analyses in patients with metastatic pancreatic cancer by Karl Brendel, Tanios Bekaii‐Saab, Patrick M Boland, Farshid Dayyani, Andrew Dean, Teresa Macarulla, Fiona Maxwell, Kabir Mody, Anna Pedret‐Dunn, Zev A Wainberg, Bin Zhang

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Practical considerations in the use of regorafenib in metastatic colorectal cancer by Fotios Loupakis, Lorenzo Antonuzzo, Jean-Baptiste Bachet, Feng-Che Kuan, Teresa Macarulla, Filippo Pietrantonio, Rui-Hua Xu, Hiroya Taniguchi, Thomas Winder, Satoshi Yuki, Shan Zeng, Tanios Bekaii-Saab

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Quality of life of patients with metastatic pancreatic adenocarcinoma initiating first-line chemotherapy in routine practice by Berta Laquente, Teresa Macarulla, Cristina Bugés, Marta Martín, Carlos García, Carles Pericay, Sandra Merino, Laura Visa, Teresa Martín, Manuela Pedraza, Beatriz Carnero, Raquel Guardeño, Helena Verdaguer, Alejandro Mut, David Vilanova, Adelaida García

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Real-world effectiveness and safety of second- or third-line pegylated liposomal irinotecan plus 5-fluorouracil and folinic acid in pancreatic ductal adenocarcinoma in Spain by Rafael Álvarez-Gallego, Roberto Pazo-Cid, Borja López de San Vicente, Teresa Macarulla, Eva Martinez, Fernando Garicano, Irene Hernández, Monica Granja, Ismael Ghanem, Joaquina Martinez, Paula Ribera, Roberto Diaz, Jose Ignacio Martin Valadés, Maria Cristina Angeles, Antonio Cubillo

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Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer by Antoine Hollebecque, Rocio Garcia-Carbonero, Do-Youn Oh, Emiliano Calvo, Davide Melisi, Teresa Macarulla, Valeria Merz, Erkut Borazanci, Anna Varghese, Camilla Zecchetto, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Shawn T Estrem, Karim A Benhadji, Emin Avsar, Susan C Guba

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ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA by Ariana Huebner, James R. M. Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A. Toledo

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Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights by Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Ignacio Matos, Enrique Sanz‐Garcia, Carolina Ortiz, Teresa Macarulla, Jaume Capdevila, Maria Alsina, Tamara Sauri, Helena Verdaguer, Marta Vilaro, Fiorella Ruiz‐Pace, Cristina Viaplana, Ariadna Garcia, Stefania Landolfi, Hector G. Palmer, Paolo Nuciforo, Jordi Rodon, Ana Vivancos, Josep Tabernero

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Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS‐mutant metastatic colorectal cancer by Elena Elez, Chiara Chianese, Enrique Sanz‐García, Erica Martinelli, Alba Noguerido, Francesco Mattia Mancuso, Ginevra Caratù, Judit Matito, Julieta Grasselli, Claudia Cardone, Riziero Esposito Abate, Giulia Martini, Cristina Santos, Teresa Macarulla, Guillem Argilés, Jaume Capdevila, Ariadna Garcia, Nuria Mulet, Evaristo Maiello, Nicola Normanno, Frederick Jones, Josep Tabernero, Fortunato Ciardello, Ramon Salazar, Ana Vivancos

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Molecular profile and its clinical impact of IDH1 mutated versus IDH1 wild type intrahepatic cholangiocarcinoma by Margherita Rimini, Carles Fabregat-Franco, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini

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Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors by Gabriel Capellá, Francisco X Real, Marta Gil-Martin, Rocio Garcia-Carbonero, Rafael Moreno, Ramon Alemany, Martí Farrera-Sal, Ramon Salazar, Teresa Macarulla, Jaime Martinez de Villarreal, Natalia del Pozo, Carmen Guillén-Ponce, Miriam Bazan-Peregrino, Rafael Álvarez, Ana Mato-Berciano, Emma Blasi, Carmen Blasco, Manel Cascallo, Maria C Riesco-Martinez, Helena Verdaguer, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Noemí Vidal

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PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system by Kai Zimmer, Florian Kocher, Gerold Untergasser, Brigitte Kircher, Arno Amann, Yasmine Baca, Joanne Xiu, W. Micheal Korn, Martin D. Berger, Heinz-Josef Lenz, Alberto Puccini, Elisa Fontana, Anthony F. Shields, John L. Marshall, Michael Hall, Wafik S. El-Deiry, David Hsiehchen, Teresa Macarulla, Josep Tabernero, Renate Pichler, Moh’d Khushman, Upender Manne, Emil Lou, Dominik Wolf, Viktorija Sokolova, Simon Schnaiter, Alain G. Zeimet, Pat Gulhati, Gerlig Widmann, Andreas Seeber

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The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models by Andrea Herencia-Ropero, Alba Llop-Guevara, Anna D. Staniszewska, Joanna Domènech-Vivó, Eduardo García-Galea, Alejandro Moles-Fernández, Flaminia Pedretti, Heura Domènech, Olga Rodríguez, Marta Guzmán, Enrique J. Arenas, Helena Verdaguer, Fernando J. Calero-Nieto, Sara Talbot, Luis Tobalina, Elisabetta Leo, Alan Lau, Paolo Nuciforo, Rodrigo Dienstmann, Teresa Macarulla, Joaquín Arribas, Orland Díez, Sara Gutiérrez-Enríquez, Josep V. Forment, Mark J. O’Connor, Mark Albertella, Judith Balmaña, Violeta Serra

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