Outcome of hospitalization for Covid-19 in patients with interstitial lung disease. An international multicenter study by Drake, TM, Docherty, AB, Harrison, EM, Ho, L-P, Hoyles, RK, ISARIC4C Investigators

The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020 by Gwenan M. Knight, Thi Mui Pham, James Stimson, Sebastian Funk, Yalda Jafari, Diane Pople, Stephanie Evans, Mo Yin, Colin S. Brown, Alex Bhattacharya, Russell Hope, Malcolm G. Semple, ISARIC4C Investigators, CMMID COVID-19 Working Group, Jonathan M. Read, Ben S. Cooper, Julie V. Robotham

Get full text

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, pr... by Russell, CD, Fairfield, CJ, Drake, TM, Turtle, L, Seaton, RA, Wootton, DG, Sigfrid, L, Harrison, EM, Docherty, AB, de Silva, TI, Egan, C, Pius, R, Hardwick, HE, Merson, L, Girvan, M, Dunning, J, Nguyen-Van-Tam, JS, Openshaw, PJM, Baillie, JK, Semple, MG, Ho, A, ISARIC4C investigators, Horby, PW

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study. by Lance Turtle, Mathew Thorpe, Thomas M Drake, Maaike Swets, Carlo Palmieri, Clark D Russell, Antonia Ho, Stephen Aston, Daniel G Wootton, Alex Richter, Thushan I de Silva, Hayley E Hardwick, Gary Leeming, Andy Law, Peter J M Openshaw, Ewen M Harrison, ISARIC4C investigators, J Kenneth Baillie, Malcolm G Semple, Annemarie B Docherty

Get full text

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study by Docherty, AB, Harrison, EW, Green, CA, Hardwick, HE, Pius, R, Norman, L, Holden, KA, Read, JM, Dondelinger, F, Carson, G, Merson, L, Lee, J, Plotkin, D, Sigfrid, L, Halpin, S, Jackson, C, Gamble, C, Horby, PW, Nguyen-Van-Tam, JS, Ho, A, Russell, CD, Dunning, J, Openshaw, PJ, Baillie, JK, Semple, MG, ISARIC4C investigators

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity by Maaike C. Swets, Steven Kerr, James Scott-Brown, Adam B. Brown, Rishi Gupta, Jonathan E. Millar, Enti Spata, Fiona McCurrach, Andrew D. Bretherick, Annemarie Docherty, David Harrison, Kathy Rowan, Neil Young, ISARIC4C Investigators, Geert H. Groeneveld, Jake Dunning, Jonathan S. Nguyen-Van-Tam, Peter Openshaw, Peter W. Horby, Ewen Harrison, Natalie Staplin, Malcolm G. Semple, Nazir Lone, J. Kenneth Baillie

Get full text

HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation by Yang, H, Sun, H, Brackenridge, S, Zhuang, X, Wing, PAC, Quastel, M, Walters, L, Garner, L, Wang, B, Yao, X, Felce, SL, Peng, Y, Moore, S, Peeters, BWA, Rei, M, Canto Gomes, J, Tomas, A, Davidson, A, Semple, MG, Turtle, LCW, Openshaw, PJM, Baillie, JK, Mentzer, AJ, Klenerman, P, ISARIC4C Investigators, Borrow, P, Dong, T, McKeating, JA, Gillespie, GM, McMichael, AJ

Accelerated immune ageing is associated with COVID-19 disease severity by Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling, Betty Raman, Michael Marks, Amisha Singapuri, Omer Elneima, Peter J. M. Openshaw, Niharika A. Duggal, on behalf of the PHOSP-COVID Study collaborative group, ISARIC4C investigators

Get full text

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study by Eleanor Parker, Jordan Thomas, Kelly J. Roper, Samreen Ijaz, Tansy Edwards, Federica Marchesin, Ksenia Katsanovskaja, Lauren Lett, Christopher Jones, Hayley E. Hardwick, Chris Davis, Elen Vink, Sarah E. McDonald, Shona C. Moore, Steve Dicks, Steve Dicks, Keerthana Jegatheesan, Keerthana Jegatheesan, Nicola J. Cook, Joshua Hope, Peter Cherepanov, Myra O. McClure, J. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, Antonia Ho, Malcolm G. Semple, William A. Paxton, Richard S. Tedder, Georgios Pollakis, ISARIC4C Investigators

Get full text

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection by Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox

Get full text

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 by Thompson, CP, Grayson, N, Paton, R, Bolton, JS, Lourenco, J, Penman, B, Lee, LN, Odon, V, Mongkolsapaya, J, Chinnakannan, S, Dejnirattisai, W, Edmans, M, Fyfe, A, Imlach, C, Kooblall, K, Lim, N, Liu, C, Lopez-Camacho, C, McInally, C-A, McNaughton, AL, Ramamurthy, N, Ratcliff, J, Supasa, P, Wang, B, Mentzer, AJ, Turner, M, Sampson, O, Semple, C, Baillie, JK, ISARIC4C Investigators, Harvala, H, Screaton, G, Temperton, N, Klenerman, P, Jarvis, L, Gupta, S, Simmonds, P

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study by Gupta, RK, Harrison, EM, Ho, A, Docherty, AB, Knight, SR, van Smeden, M, Abubakar, I, Lipman, M, Quartagno, M, Pius, R, Buchan, I, Carson, G, Drake, TM, Dunning, J, Fairfield, CJ, Gamble, C, Green, CA, Halpin, S, Hardwick, HE, Holden, KA, Horby, PW, Jackson, C, Mclean, KA, Merson, L, Nguyen-Van-Tam, JS, Norman, L, Olliaro, PL, Pritchard, MG, Russell, CD, Scott-Brown, J, Shaw, CA, Sheikh, A, Solomon, T, Sudlow, C, Swann, OV, Turtle, L, Openshaw, PJM, Baillie, JK, Semple, MG, Noursadeghi, M, ISARIC4C Investigators

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses by Benedict D. Michael, Cordelia Dunai, Edward J. Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Greta K. Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A. Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N. Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P. Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J. Coles, Nathalie Kingston, John R. Bradley, Patrick F. Chinnery, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, J. Kenneth Baillie, Peter J. Openshaw, Malcolm G. Semple, ISARIC4C Investigators, COVID-CNS Consortium, Leonie S. Taams, David K. Menon

Get full text

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses by Benedict D. Michael, Cordelia Dunai, Edward J. Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Greta K. Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A. Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N. Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P. Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J. Coles, Nathalie Kingston, John R. Bradley, Patrick F. Chinnery, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, J. Kenneth Baillie, Peter J. Openshaw, Malcolm G. Semple, ISARIC4C Investigators, COVID-CNS Consortium, Leonie S. Taams, David K. Menon

Get full text

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses by Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan Youngs, Judith Wellens, Prabhjeet Phalora, Alex Fyfe, Sandra Belij-Rammerstorfer, Jai S. Bolton, Jonathan Ball, George W. Carnell, Wanwisa Dejnirattisai, Christina Dold, David W. Eyre, Philip Hopkins, Alison Howarth, Kreepa Kooblall, Hannah Klim, Susannah Leaver, Lian Ni Lee, César López-Camacho, Sheila F. Lumley, Derek C. Macallan, Alexander J. Mentzer, Nicholas M. Provine, Jeremy Ratcliff, Jose Slon-Compos, Donal Skelly, Lucas Stolle, Piyada Supasa, Nigel Temperton, Chris Walker, Beibei Wang, Duncan Wyncoll, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) consortium, Scottish National Blood Transfusion Service (SNBTS) consortium, Peter Simmonds, Teresa Lambe, John Kenneth Baillie, Malcolm G. Semple, Peter J.M. Openshaw, International Severe Acute Respiratory and emerging Infection Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) investigators, Uri Obolski, Marc Turner, Miles Carroll, Juthathip Mongkolsapaya, Gavin Screaton, Stephen H. Kennedy, Lisa Jarvis, Eleanor Barnes, Susanna Dunachie, José Lourenço, Philippa C. Matthews, Tihana Bicanic, Paul Klenerman, Sunetra Gupta, Craig P. Thompson

Get full text

Delayed mucosal antiviral responses despite robust peripheral inflammation in fatal COVID-19 by Sidhu, JK, Siggins, MK, Liew, F, Russell, CD, Uruchurtu, ASS, Davis, C, Turtle, L, Moore, SC, Hardwick, HE, Oosthuyzen, W, Thomson, EC, Semple, MG, Baillie, JK, Openshaw, PJM, Thwaites, RS

Other Authors: “…ISARIC4C investigators…”

Long Covid in adults discharged from UK hospitals after Covid-19: a prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol by Sigfrid, LA, Drake, TM, Pauley, E, Jesudason, EC, Olliaro, P, Lim, WS, Gillesen, A, Berry, C, Lowe, DJ, McPeake, J, Lone, N, Munblit, D, Cevik, M, Casey, A, Bannister, P, Russell, CD, Goodwin, L, Ho, A, Turtle, L, O'Hara, ME, Hastie, C, Donohue, C, Spencer, RG, Donegan, C, Gummery, A, Harrison, J, Hardwick, HE, Hastie, CE, Carson, G, Merson, L, Baillie, JK, Openshaw, P, Harrison, EM, Docherty, AB, Semple, MG, Scott, JT

Other Authors: “…ISARIC4C investigators…”

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England by Leclerc, QJ, Fuller, NM, Keogh, RH, Diaz-Ordaz, K, Sekula, R, Semple, MG, Atkins, KE, Procter, SR, Knight, GM, Horby, P

Other Authors: “…ISARIC4C Investigators…”

Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19 by Devine, K, Russell, CD, Blanco, GR, Walker, BR, Homer, NZM, Denham, SG, Simpson, JP, Leavy, OC, Elneima, O, McAuley, HJC, Shikotra, A, Singapuri, A, Sereno, M, Saunders, RM, Harris, VC, Houchen-Wolloff, L, Greening, NJ, Lone, NI, Thorpe, M, Greenhalf, W, Chalmers, JD, Ho, L-P, Horsley, A, Marks, M, Raman, B, Moore, SC, Dunning, J, Semple, MG, Andrew, R, Wain, LV, Evans, RA, Brightling, CE, Kenneth Baillie, J, Reynolds, RM

Other Authors: “…ISARIC4C Investigators…”

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses by Michael, BD, Dunai, C, Needham, EJ, Tharmaratnam, K, Williams, R, Huang, Y, Boardman, SA, Clark, JJ, Sharma, P, Subramaniam, K, Wood, GK, Collie, C, Digby, R, Ren, A, Norton, E, Leibowitz, M, Ebrahimi, S, Fower, A, Fox, H, Tato, E, Ellul, MA, Sunderland, G, Held, M, Hetherington, C, Egbe, FN, Palmos, A, Stirrups, K, Grundmann, A, Chiollaz, A-C, Sanchez, J-C, Stewart, JP, Griffiths, M, Solomon, T, Breen, G, Coles, AJ, Kingston, N, Bradley, JR, Chinnery, PF, Cavanagh, J, Irani, SR, Vincent, A, Baillie, JK, Openshaw, PJ, Semple, MG, Taams, LS, Menon, DK, Horby, PW, Klenerman, P, Merson, L, Sigfrid, L, Stuart, D, Lee, J, Plotkin, D, Carson, G, Duff, E, Miller, K, Husain, M, Harrison, PJ, Jezzard, P, Smith, S

Other Authors: “…ISARIC4C Investigators…”