Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks by Minsu Kim, Jennifer E. Huffman, Amy Justice, Ian Goethert, Greeshma Agasthya, VA Million Veteran Program, Ioana Danciu

Get full text

A statistical quality assessment method for longitudinal observations in electronic health record data with an application to the VA million veteran program by Hui Wang, Ilana Belitskaya-Levy, Fan Wu, Jennifer S. Lee, Mei-Chiung Shih, Philip S. Tsao, Ying Lu, on behalf of VA Million Veteran Program

Get full text

Self-reported physical functioning, cardiometabolic health conditions, and health care utilization patterns in Million Veteran Program enrollees with Traumatic Brain Injury Screeni... by Alexandra L. Clark, Makenna B. McGill, Erin D. Ozturk, David M. Schnyer, Catherine Chanfreau-Coffinier, Victoria C. Merritt, the VA Million Veteran Program

Get full text

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits by William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, The VA Million Veteran Program, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight

Get full text

Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program by Dong D. Wang, Yanping Li, Xuan-Mai T. Nguyen, Rebecca J. Song, Yuk-Lam Ho, Frank B. Hu, Walter C. Willett, Peter W. F. Wilson, Kelly Cho, J. Michael Gaziano, Luc Djoussé, on behalf of the VA Million Veteran Program

Get full text

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals by Ke Xu, Boyang Li, Kathleen A. McGinnis, Rachel Vickers-Smith, Cecilia Dao, Ning Sun, Rachel L. Kember, Hang Zhou, William C. Becker, Joel Gelernter, Henry R. Kranzler, Hongyu Zhao, Amy C. Justice, VA Million Veteran Program

Get full text

Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy by Xuan Wang, Molei Liu, Isabelle-Emmanuella Nogues, Tony Chen, Xin Xiong, Clara-Lea Bonzel, Harrison Zhang, Chuan Hong, Yin Xia, Kumar Dahal, Lauren Costa, Jing Cui, VA Million Veteran Program, J. Michael Gaziano, Seoyoung C. Kim, Yuk-Lam Ho, Kelly Cho, Tianxi Cai, Katherine P. Liao

Get full text

Genetic architecture of heart failure with preserved versus reduced ejection fraction by Jacob Joseph, Chang Liu, Qin Hui, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djousse, Juan P. Casas, J. Michael Gaziano, Kelly Cho, Peter W. F. Wilson, Lawrence S. Phillips, VA Million Veteran Program, Christopher J. O’Donnell, Yan V. Sun

Get full text

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort. by Aeron M Small, Jennifer E Huffman, Derek Klarin, Julie A Lynch, Themistocles Assimes, Scott DuVall, Yan V Sun, Labiba Shere, Pradeep Natarajan, Michael Gaziano, Daniel J Rader, Peter W F Wilson, Philip S Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Juan P Casas, Scott M Damrauer, VA Million Veteran Program

Get full text

A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation by Bryan R. Gorman, Michael Francis, Cari L. Nealon, Christopher W. Halladay, Nalvi Duro, Kyriacos Markianos, Giulio Genovese, Pirro G. Hysi, Hélène Choquet, Natalie A. Afshari, Yi-Ju Li, VA Million Veteran Program, J. Michael Gaziano, Adriana M. Hung, Wen-Chih Wu, Paul B. Greenberg, Saiju Pyarajan, Jonathan H. Lass, Neal S. Peachey, Sudha K. Iyengar

Get full text

Pharmacogenetic variants and risk of remdesivir‐associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID‐19 by Sony Tuteja, Zhihong Yu, Otis Wilson, Hua‐Chang Chen, Frank Wendt, Cecilia P. Chung, Shailja C. Shah, Christine M. Hunt, Ayako Suzuki, Catherine Chanfreau, Bryan R. Gorman, Jacob Joseph, Shiuh‐Wen Luoh, Valerio Napolioni, Cassianne Robinson‐Cohen, Ran Tao, Jin Zhou, Kyong‐Mi Chang, Adriana M. Hung, the VA Million Veteran Program COVID‐19 Science Initiative

Get full text

Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data by Chuan Hong, Everett Rush, Molei Liu, Doudou Zhou, Jiehuan Sun, Aaron Sonabend, Victor M. Castro, Petra Schubert, Vidul A. Panickan, Tianrun Cai, Lauren Costa, Zeling He, Nicholas Link, Ronald Hauser, J. Michael Gaziano, Shawn N. Murphy, George Ostrouchov, Yuk-Lam Ho, Edmon Begoli, Junwei Lu, Kelly Cho, Katherine P. Liao, Tianxi Cai, VA Million Veteran Program

Get full text

Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program by Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera-Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, VA Million Veteran Program, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, Renato Polimanti, Department of Veteran Affairs Cooperative Study Program (#2006)

Get full text

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program by Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A. Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E. North, the VA Million Veteran Program, Ethan Lange, Leslie A. Lange, Benjamin F. Voight, J. Michael Gaziano, Saiju Pyarajan, Elizabeth R. Hauser, Philip S. Tsao, Peter W. F. Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes

Get full text

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. by Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E North, VA Million Veteran Program, Ethan Lange, Leslie A Lange, Benjamin F Voight, J Michael Gaziano, Saiju Pyarajan, Elizabeth R Hauser, Philip S Tsao, Peter W F Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Yan V Sun, Themistocles L Assimes

Get full text

Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program. by Allison E Ashley-Koch, Nathan A Kimbrel, Xue J Qin, Jennifer H Lindquist, Melanie E Garrett, Michelle F Dennis, Lauren P Hair, Jennifer E Huffman, Daniel A Jacobson, Ravi K Madduri, Hilary Coon, Anna R Docherty, Jooeun Kang, Niamh Mullins, Douglas M Ruderfer, VA Million Veteran Program (MVP), MVP Suicide Exemplar Workgroup, International Suicide Genetics Consortium, Philip D Harvey, Benjamin H McMahon, David W Oslin, Elizabeth R Hauser, Michael A Hauser, Jean C Beckham

Get full text

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program. by Marina Serper, Marijana Vujkovic, David E Kaplan, Rotonya M Carr, Kyung Min Lee, Qing Shao, Donald R Miller, Peter D Reaven, Lawrence S Phillips, Christopher J O'Donnell, James B Meigs, Peter W F Wilson, Rachel Vickers-Smith, Henry R Kranzler, Amy C Justice, John M Gaziano, Sumitra Muralidhar, Saiju Pyarajan, Scott L DuVall, Themistocles L Assimes, Jennifer S Lee, Philip S Tsao, Daniel J Rader, Scott M Damrauer, Julie A Lynch, Danish Saleheen, Benjamin F Voight, Kyong-Mi Chang, VA Million Veteran Program

Get full text

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure by Danielle Rasooly, Gina M. Peloso, Alexandre C. Pereira, Hesam Dashti, Claudia Giambartolomei, Eleanor Wheeler, Nay Aung, Brian R. Ferolito, Maik Pietzner, Eric H. Farber-Eger, Quinn Stanton Wells, Nicole M. Kosik, Liam Gaziano, Daniel C. Posner, A. Patrícia Bento, Qin Hui, Chang Liu, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Peter W. F. Wilson, Lawrence S. Phillips, John Whittaker, Patricia B. Munroe, Steffen E. Petersen, Kelly Cho, Andrew R. Leach, María Paula Magariños, John Michael Gaziano, VA Million Veteran Program, Claudia Langenberg, Yan V. Sun, Jacob Joseph, Juan P. Casas

Get full text

A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility by Georgios Voloudakis, James M. Vicari, Sanan Venkatesh, Gabriel E. Hoffman, Kristina Dobrindt, Wen Zhang, Noam D. Beckmann, Christina A. Higgins, Stathis Argyriou, Shan Jiang, Daisy Hoagland, Lina Gao, André Corvelo, Kelly Cho, Kyung Min Lee, Jiantao Bian, Jennifer S. Lee, Sudha K. Iyengar, Shiuh-Wen Luoh, Schahram Akbarian, Robert Striker, Themistocles L. Assimes, Eric E. Schadt, Julie A. Lynch, Miriam Merad, Benjamin R. tenOever, Alexander W. Charney, Mount Sinai COVID-19 Biobank, VA Million Veteran Program COVID-19 Science Initiative, Kristen J. Brennand, John F. Fullard, Panos Roussos

Get full text

Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program by Gina M. Peloso, Gina M. Peloso, Catherine Tcheandjieu, Catherine Tcheandjieu, Catherine Tcheandjieu, John E. McGeary, John E. McGeary, Daniel C. Posner, Yuk-Lam Ho, Jin J. Zhou, Jin J. Zhou, Austin T. Hilliard, Jacob Joseph, Jacob Joseph, Jacob Joseph, Christopher J. O’Donnell, Christopher J. O’Donnell, Christopher J. O’Donnell, Jimmy T. Efird, Dana C. Crawford, Dana C. Crawford, Dana C. Crawford, Dana C. Crawford, Wen-Chih Wu, Wen-Chih Wu, Mehrdad Arjomandi, Mehrdad Arjomandi, VA Million Veteran Program COVID-19 Science Initiative, Yan V. Sun, Yan V. Sun, Themistocles L Assimes, Themistocles L Assimes, Themistocles L Assimes, Jennifer E. Huffman

Get full text