Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIV [version 1; peer review: 2 approved] by Simon C Mendelsohn, Humphrey Mulenga, Savannah Verhage, Thomas J Scriba, Mark Hatherill

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St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. by Britta Kleemann, Benjamin Loos, Thomas J Scriba, Dirk Lang, Lester M Davids

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Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIV [version 2; peer review: 2 approved] by Simon C Mendelsohn, Humphrey Mulenga, Savannah Verhage, Thomas J Scriba, Mark Hatherill

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T cell responses to Mycobacterium indicus pranii immunotherapy and adjunctive glucocorticoid therapy in tuberculous pericarditis by Pia Steigler, Mukesh Chhiba, Veronica Francis, Alana Keyser, Deborah Abrahams, Willem Hanekom, Mpiko Ntsekhe, Thomas J. Scriba

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Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba

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Immune Phenotype and Functionality of <i>Mtb-</i>Specific<i> </i>T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment by Lucy Mupfumi, Cheleka A.M. Mpande, Tim Reid, Sikhulile Moyo, Sanghyuk S. Shin, Nicola Zetola, Tuelo Mogashoa, Rosemary M. Musonda, Ishmael Kasvosve, Thomas J. Scriba, Elisa Nemes, Simani Gaseitsiwe

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Diagnostic biomarkers for active tuberculosis: progress and challenges by Betânia M F Nogueira, Sonya Krishnan, Beatriz Barreto‐Duarte, Mariana Araújo‐Pereira, Artur T L Queiroz, Jerrold J Ellner, Padmini Salgame, Thomas J Scriba, Timothy R Sterling, Amita Gupta, Bruno B Andrade

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Evaluation of a transcriptomic signature of tuberculosis risk in combination with an interferon gamma release assay: A diagnostic test accuracy study by Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Elisa Nemes, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill

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Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants by Iman Satti, Rachel E. Wittenberg, Shuailin Li, Stephanie A. Harris, Rachel Tanner, Deniz Cizmeci, Ashley Jacobs, Nicola Williams, Humphrey Mulenga, Helen A. Fletcher, Thomas J. Scriba, Michele Tameris, Mark Hatherill, Helen McShane

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Virome-wide detection of natural infection events and the associated antibody dynamics using longitudinal highly-multiplexed serology by Erin J. Kelley, Sierra N. Henson, Fatima Rahee, Annalee S. Boyle, Anna L. Engelbrektson, Georgia A. Nelson, Heather L. Mead, N. Leigh Anderson, Morteza Razavi, Richard Yip, Jason T. Ladner, Thomas J. Scriba, John A. Altin

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Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production by Shyamala Thirunavukkarasu, Mushtaq Ahmed, Bruce A. Rosa, Mark Boothby, Sung Hoon Cho, Javier Rangel-Moreno, Stanley K. Mbandi, Valérie Schreiber, Ananya Gupta, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Thomas J. Scriba, Shabaana A. Khader

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A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. by Cecilia S Lindestam Arlehamn, Denise M McKinney, Chelsea Carpenter, Sinu Paul, Virginie Rozot, Edward Makgotlho, Yolande Gregg, Michele van Rooyen, Joel D Ernst, Mark Hatherill, Willem A Hanekom, Bjoern Peters, Thomas J Scriba, Alessandro Sette

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Newborn bacille Calmette-Guérin vaccination induces robust infant interferon-γ-expressing natural killer cell responses to mycobacteria by Melissa Murphy, Sara Suliman, Libby Briel, Helen Veldtsman, Nondumiso Khomba, Hadn Africa, Marcia Steyn, Candice I. Snyders, Ilana C. van Rensburg, Gerhard Walzl, Novel N. Chegou, Mark Hatherill, Willem A. Hanekom, Thomas J. Scriba, Elisa Nemes

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Non-volatile organic compounds in exhaled breath particles correspond to active tuberculosis by Dapeng Chen, Noella A. Bryden, Wayne A. Bryden, Michael McLoughlin, Dexter Smith, Alese P. Devin, Emily R. Caton, Caroline R. Haddaway, Michele Tameris, Thomas J. Scriba, Mark Hatherill, Sophia Gessner, Digby F. Warner, Robin Wood

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Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition. by Rachel A Bender Ignacio, Jessica Long, Aparajita Saha, Felicia K Nguyen, Lara Joudeh, Ethan Valinetz, Simon C Mendelsohn, Thomas J Scriba, Mark Hatherill, Holly Janes, Gavin Churchyard, Susan Buchbinder, Ann Duerr, Javeed A Shah, Thomas R Hawn

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Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population. by Richard Baguma, Adam Penn-Nicholson, Erica Smit, Mzwandile Erasmus, Jonathan Day, Lebohang Makhethe, Marwou de Kock, E Jane Hughes, Michele van Rooyen, Bernadette Pienaar, Lynnett Stone, Willem Hanekom, Michael J Brennan, Robert S Wallis, Mark Hatherill, Thomas J Scriba

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HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection by Linda Voogd, Catherine Riou, Catherine Riou, Thomas J. Scriba, Marjolein van Wolfswinkel, Krista E. van Meijgaarden, Kees L. M. C. Franken, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Tom H. M. Ottenhoff, Simone A. Joosten

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<em>Mtb</em>-Specific HLA-E-Restricted T Cells Are Induced during <em>Mtb</em> Infection but Not after BCG Administration in Non-Human Primates and Humans by Linda Voogd, Marjolein van Wolfswinkel, Iman Satti, Andrew D. White, Karin Dijkman, Anele Gela, Krista E. van Meijgaarden, Kees L. M. C. Franken, Julia L. Marshall, Tom H. M. Ottenhoff, Thomas J. Scriba, Helen McShane, Sally A. Sharpe, Frank A. W. Verreck, Simone A. Joosten

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Co-regulation of innate and adaptive immune responses induced by ID93+GLA-SE vaccination in humans by Andrew Fiore-Gartland, Himangi Srivastava, Aaron Seese, Tracey Day, Adam Penn-Nicholson, Angelique Kany Kany Luabeya, Nelita Du Plessis, Andre G. Loxton, Linda-Gail Bekker, Andreas Diacon, Gerhard Walzl, Zachary K. Sagawa, Steven G. Reed, Thomas J. Scriba, Mark Hatherill, Rhea Coler, Rhea Coler, Rhea Coler

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Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis by Stuart Meier, James A. Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Stephanus T. Malherbe, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Stefan H. E. Kaufmann, Tom H. M. Ottenhoff, Thomas J. Scriba, Sara Suliman, Jayne S. Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard Tromp

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