Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk by Robert K. Lesniak, Robert K. Lesniak, R. Jeremy Nichols, Thomas J. Montine

Get full text

regionalpcs improve discovery of DNA methylation associations with complex traits by Tiffany Eulalio, Min Woo Sun, Olivier Gevaert, Michael D. Greicius, Thomas J. Montine, Daniel Nachun, Stephen B. Montgomery

Get full text

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. by Marie Y Davis, Kien Trinh, Ruth E Thomas, Selina Yu, Alexandre A Germanos, Brittany N Whitley, Sergio Pablo Sardi, Thomas J Montine, Leo J Pallanck

Get full text

Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra by Melanie J. Plastini, Carla Abdelnour, Christina B. Young, Edward N. Wilson, Marian Shahid‐Besanti, Jennifer Lamoureux, Katrin I. Andreasson, Geoffrey A. Kerchner, Thomas J. Montine, Victor W. Henderson, Kathleen L. Poston

Get full text

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain by Anna-Lena Lang, Tiffany Eulalio, Eddie Fox, Koya Yakabi, Syed A. Bukhari, Claudia H. Kawas, Maria M. Corrada, Stephen B. Montgomery, Frank L. Heppner, David Capper, Daniel Nachun, Thomas J. Montine

Get full text

Understanding the molecular basis of resilience to Alzheimer’s disease by Kathleen S. Montine, Eloïse Berson, Eloïse Berson, Thanaphong Phongpreecha, Thanaphong Phongpreecha, Zhi Huang, Zhi Huang, Nima Aghaeepour, Nima Aghaeepour, James Y. Zou, James Y. Zou, Michael J. MacCoss, Thomas J. Montine

Get full text

Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease by Zhi Huang, Gennifer E. Merrihew, Eric B. Larson, Jea Park, Deanna Plubell, Edward J. Fox, Kathleen S. Montine, Caitlin S. Latimer, C. Dirk Keene, James Y. Zou, Michael J. MacCoss, Thomas J. Montine

Get full text

Unveiling Resilience to Alzheimer’s Disease: Insights From Brain Regional Proteomic Markers by Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna Plubell, Edward J Fox, Kathleen S Montine, C Dirk Keene, Caitlin S Latimer, James Y Zou, Michael J MacCoss, Thomas J Montine

Get full text

Phenotypic Heterogeneity among <i>GBA</i> p.R202X Carriers in Lewy Body Spectrum Disorders by Valerio Napolioni, Carolyn A. Fredericks, Yongha Kim, Divya Channappa, Raiyan R. Khan, Lily H. Kim, Faria Zafar, Julien Couthouis, Guido A. Davidzon, Elizabeth C. Mormino, Aaron D. Gitler, Thomas J. Montine, Birgitt Schüle, Michael D. Greicius

Get full text

Quantitative estimate of cognitive resilience and its medical and genetic associations by Thanaphong Phongpreecha, Dana Godrich, Eloise Berson, Camilo Espinosa, Yeasul Kim, Brenna Cholerton, Alan L. Chang, Samson Mataraso, Syed A. Bukhari, Amalia Perna, Koya Yakabi, Kathleen S. Montine, Kathleen L. Poston, Elizabeth Mormino, Lon White, Gary Beecham, Nima Aghaeepour, Thomas J. Montine

Get full text

Whole genome deconvolution unveils Alzheimer’s resilient epigenetic signature by Eloise Berson, Anjali Sreenivas, Thanaphong Phongpreecha, Amalia Perna, Fiorella C. Grandi, Lei Xue, Neal G. Ravindra, Neelufar Payrovnaziri, Samson Mataraso, Yeasul Kim, Camilo Espinosa, Alan L. Chang, Martin Becker, Kathleen S. Montine, Edward J. Fox, Howard Y. Chang, M. Ryan Corces, Nima Aghaeepour, Thomas J. Montine

Get full text

Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease by Rosie Morris, Douglas N. Martini, Valerie E. Kelly, Katrijn Smulders, Katrina Ramsey, Amie Hiller, Kathryn A. Chung, Shu-Ching Hu, Cyrus P. Zabetian, Kathleen L. Poston, Ignacio F. Mata, Karen L. Edwards, Jodi Lapidus, Brenna Cholerton, Thomas J. Montine, Joseph F. Quinn, Fay Horak

Get full text

Cognition as a mediator for gait and balance impairments in GBA-related Parkinson’s disease by Rosie Morris, Douglas N. Martini, Katrina Ramsey, Valerie E. Kelly, Katrijn Smulders, Amie Hiller, Kathryn A. Chung, Shu-Ching Hu, Cyrus P. Zabetian, Kathleen L. Poston, Ignacio F. Mata, Karen L. Edwards, Jodi Lapidus, Brenna Cholerton, Thomas J. Montine, Joseph F. Quinn, Fay Horak

Get full text

A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer’s disease by Gennifer E. Merrihew, Jea Park, Deanna Plubell, Brian C. Searle, C. Dirk Keene, Eric B. Larson, Randall Bateman, Richard J. Perrin, Jasmeer P. Chhatwal, Martin R. Farlow, Catriona A. McLean, Bernardino Ghetti, Kathy L. Newell, Matthew P. Frosch, Thomas J. Montine, Michael J. MacCoss

Get full text

Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid by Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus P. Zabetian, Elaine R. Peskind, Ge Li, Daniel E. L. Promislow, Marie Y. Davis, Alexander Franks

Get full text

Impact of a deep learning assistant on the histopathologic classification of liver cancer by Amirhossein Kiani, Bora Uyumazturk, Pranav Rajpurkar, Alex Wang, Rebecca Gao, Erik Jones, Yifan Yu, Curtis P. Langlotz, Robyn L. Ball, Thomas J. Montine, Brock A. Martin, Gerald J. Berry, Michael G. Ozawa, Florette K. Hazard, Ryanne A. Brown, Simon B. Chen, Mona Wood, Libby S. Allard, Lourdes Ylagan, Andrew Y. Ng, Jeanne Shen

Get full text

Single-cell spatial proteomic imaging for human neuropathology by Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J. P. Oliveria, Syed A. Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin F. McCaffrey, Noah F. Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S. Montine, R. Michael Angelo, Thomas J. Montine, Sean C. Bendall

Get full text

Cross-species comparative analysis of single presynapses by Eloïse Berson, Chandresh R. Gajera, Thanaphong Phongpreecha, Amalia Perna, Syed A. Bukhari, Martin Becker, Alan L. Chang, Davide De Francesco, Camilo Espinosa, Neal G. Ravindra, Nadia Postupna, Caitlin S. Latimer, Carol A. Shively, Thomas C. Register, Suzanne Craft, Kathleen S. Montine, Edward J. Fox, C. Dirk Keene, Sean C. Bendall, Nima Aghaeepour, Thomas J. Montine

Get full text

Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort by Thanaphong Phongpreecha, Kavita Mathi, Brenna Cholerton, Eddie J. Fox, Natalia Sigal, Camilo Espinosa, Momsen Reincke, Philip Chung, Ling-Jen Hwang, Chandresh R. Gajera, Eloise Berson, Amalia Perna, Feng Xie, Chi-Hung Shu, Debapriya Hazra, Divya Channappa, Jeffrey E. Dunn, Lucas B. Kipp, Kathleen L. Poston, Kathleen S. Montine, Holden T. Maecker, Nima Aghaeepour, Thomas J. Montine

Get full text

Developing a Research Center for Artificial Intelligence in Medicine by Curtis P. Langlotz, MD, PhD, Johanna Kim, MPH, MBA, Nigam Shah, MBBS, PhD, Matthew P. Lungren, MD, MPH, David B. Larson, MD, MBA, Somalee Datta, PhD, Fei Fei Li, PhD, Ruth O’Hara, PhD, Thomas J. Montine, MD, PhD, Robert A. Harrington, MD, Garry E. Gold, MD, MS

Get full text