Enzyme Is the Name—Adapter Is the Game by Michael Huber, Tilman Brummer

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Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth by Lena Hölzen, Lena Hölzen, Lena Hölzen, Lena Hölzen, Kerstin Syré, Jan Mitschke, Tilman Brummer, Tilman Brummer, Tilman Brummer, Tilman Brummer, Tilman Brummer, Cornelius Miething, Cornelius Miething, Cornelius Miething, Cornelius Miething, Thomas Reinheckel, Thomas Reinheckel, Thomas Reinheckel, Thomas Reinheckel

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Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation by Thomas Yul Avery, Natalie Köhler, Natalie Köhler, Robert Zeiser, Robert Zeiser, Tilman Brummer, Tilman Brummer, Tilman Brummer, Dietrich Alexander Ruess, Dietrich Alexander Ruess

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Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines by Melanie Boerries, Ricarda Herr, Tilman Brummer, Hauke Busch

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Immune modulatory effects of oncogenic KRAS in cancer by Shaima’a Hamarsheh, Olaf Groß, Tilman Brummer, Robert Zeiser

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The mTOR pathway controls phosphorylation of BRAF at T401 by Daniel Christen, Manuel Lauinger, Melanie Brunner, Jörn Dengjel, Tilman Brummer

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Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase by Lino Rohrer, Corinna Spohr, Carina Beha, Ricarda Griffin, Sandra Braun, Sebastian Halbach, Tilman Brummer

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Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts by Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Silke Kowar, Manching Ku, Tilman Brummer, Melanie Boerries

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Strong negative feedback from Erk to Raf confers robustness to MAPK signalling by Raphaela Fritsche‐Guenther, Franziska Witzel, Anja Sieber, Ricarda Herr, Nadine Schmidt, Sandra Braun, Tilman Brummer, Christine Sers, Nils Blüthgen

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DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring by Adinarayana Marada, Corvin Walter, Tamara Suhm, Sahana Shankar, Arpita Nandy, Tilman Brummer, Ines Dhaouadi, F.-Nora Vögtle, Chris Meisinger

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ASSOCIATION AND INTERACTIONS OF THE RIO KINASES IN THE CONTEXT OF DIAMOND-BLACKFAN ANEMIA by Hans-Dajo Von Wulffen, Sheila Bohler, Corinna Spohr, Tilman Brummer, Pierre-Emmanuel Gleizes, Alexander Puzik, Charlotte Niemeyer, Miriam Erlacher

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EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. by Yvonne Möller, Martin Siegemund, Sven Beyes, Ricarda Herr, Daniele Lecis, Domenico Delia, Roland Kontermann, Tilman Brummer, Klaus Pfizenmaier, Monilola A Olayioye

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ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types by Waltraut Lehmann, Dirk Mossmann, Julia Kleemann, Kerstin Mock, Chris Meisinger, Tilman Brummer, Ricarda Herr, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz

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Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia by Katharina Sies, Corinna Spohr, Albert Gründer, Rumyana Todorova, Franziska Maria Uhl, Julia Huber, Robert Zeiser, Heike Luise Pahl, Heiko Becker, Konrad Aumann, Tilman Brummer, Sebastian Halbach

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Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling by Stephanie Ketterer, Julia Mitschke, Anett Ketscher, Manuel Schlimpert, Wilfried Reichardt, Natascha Baeuerle, Maria Elena Hess, Patrick Metzger, Melanie Boerries, Christoph Peters, Bernd Kammerer, Tilman Brummer, Florian Steinberg, Thomas Reinheckel

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Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse by Aladin Haimovici, Christoph Höfer, Mohamed Tarek Badr, Elham Bavafaye Haghighi, Tarek Amer, Melanie Boerries, Peter Bronsert, Ievgen Glavynskyi, Deborah Fanfone, Gabriel Ichim, Nico Thilmany, Arnim Weber, Tilman Brummer, Corinna Spohr, Rupert Öllinger, Klaus-Peter Janssen, Roland Rad, Georg Häcker

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The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior by Florian Weinberg, Nadine Reischmann, Lisa Fauth, Sanaz Taromi, Justin Mastroianni, Martin Köhler, Sebastian Halbach, Andrea C. Becker, Niantao Deng, Tatjana Schmitz, Franziska Maria Uhl, Nicola Herbener, Bianca Riedel, Fabian Beier, Alexander Swarbrick, Silke Lassmann, Jörn Dengjel, Robert Zeiser, Tilman Brummer

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Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery by Corvin Walter, Adinarayana Marada, Tamara Suhm, Ralf Ernsberger, Vera Muders, Cansu Kücükköse, Pablo Sánchez-Martín, Zehan Hu, Abhishek Aich, Stefan Loroch, Fiorella Andrea Solari, Daniel Poveda-Huertes, Alexandra Schwierzok, Henrike Pommerening, Stanka Matic, Jan Brix, Albert Sickmann, Claudine Kraft, Jörn Dengjel, Sven Dennerlein, Tilman Brummer, F.-Nora Vögtle, Chris Meisinger

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Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation by Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser

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Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors by Julia C. Kuehn, Patrick Metzger, Nicolas Neidert, Uta Matysiak, Linda Gräßel, Ulrike Philipp, Sabine Bleul, Thomas Pauli, Julia Falkenstein, Henriette Bertemes, Stepan Cysar, Maria Elena Hess, Anna Verena Frey, Jesús Duque-Afonso, Elisabeth Schorb, Marcia Machein, Jürgen Beck, Oliver Schnell, Nikolas von Bubnoff, Anna L. Illert, Christoph Peters, Tilman Brummer, Marco Prinz, Cornelius Miething, Heiko Becker, Silke Lassmann, Martin Werner, Melanie Börries, Justus Duyster, Dieter H. Heiland, Roman Sankowski, Florian Scherer

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