Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia by Mark S. Williams, Tim C. P. Somervaille

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Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia by Bettina Wingelhofer, Tim C. P. Somervaille

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex by Alba Maiques-Diaz, James T. Lynch, Gary J. Spencer, Tim C.P. Somervaille

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P691: MULTIOMIC SINGLE-CELL APPROACH REVEALED CLONAL ARCHITECTURE OF KIT MUTATIONS IN CHRONIC MYELOMONOCYTIC LEUKAEMIA PATIENTS WITH/WITHOUT SYSTEMIC MASTOCYTOSIS by Yu-Hung Wang, Kristian Gurashi, Tim C. P. Somervaille, Kiran Batta, Daniel Wiseman

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AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells by Stella Pearson, Rognvald Blance, Tim C.P. Somervaille, Anthony D. Whetton, Andrew Pierce

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Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients. by Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary, Fabio M R Amaral, Tim C P Somervaille, Kristina Kirschner, Anthony D Whetton, Andrew Pierce

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Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO by Francesco Camera, Isabel Romero-Camarero, Bradley H. Revell, Fabio M.R. Amaral, Oliver J. Sinclair, Fabrizio Simeoni, Daniel H. Wiseman, Lovorka Stojic, Tim C.P. Somervaille

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Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia by Tim D.D. Somerville, Fabrizio Simeoni, John A. Chadwick, Emma L. Williams, Gary J. Spencer, Katalin Boros, Christopher Wirth, Eleni Tholouli, Richard J. Byers, Tim C.P. Somervaille

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Conserved role of FOXC1 in TNBC is parallel to FOXA1 in ER+ breast cancer by Revathy Ramachandran, Shakhzada Ibragimova, Laura M. Woods, Tamader AlHouqani, Roshna Lawrence Gomez, Fabrizio Simeoni, Mahmood Y. Hachim, Tim C.P. Somervaille, Anna Philpott, Jason S. Carroll, Fahad R. Ali

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P720: A BONE MARROW MICROENVIRONMENTAL CELL SIGNATURE SCORING SYSTEM INDEPENDENTLY PREDICTED SURVIVAL AND DRUG RESISTANCE IN CHRONIC MYELOMONOCYTIC LEUKAEMIA PATIENTS by Yu-Hung Wang, Kristian Gurashi, Chien-Chin Lin, Chi-Yuan Yao, Fabio M. R. Amaral, Andres Jerez, Tim C. P. Somervaille, Hsin-An Hou, Wen Chien Chou, Kiran Batta, Daniel Wiseman, Hwei-Fang Tien

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P863: AN OPEN-LABEL PHASE I/IIA STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CCS1477 AS MONOTHERAPY AND IN COMBINATION WITH POMALIDOMIDE/DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIP... by Emma Searle, Jim Cavet, Steven Knapper, Ceri Bygrave, Victoria Campbell, Dima El-Sharkawi, Charlotte Pawlyn, Maria Creignou, Harriet S. Walter, David Valcarcel, Marta Hidalgo, Tomasz Knurowski, Karen Clegg, Neil Pegg, Will West, Debbie Haynes, Kris Frese, Tim C. P. Somervaille

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